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Autoimmunity & Inflammation
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
MMP-2
MMP-2
F0
1
CD200R
OX2R,MOX2R,CD200R
F0
IL13RA2
IL13RA2,IL-13R,IL13BP
F0
0
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Oncology
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
G-CSFR
G-CSFR
F0
96
TNF
TNF,TNFA,TNFSF2
F0
49
CD26
CD26,ADABP,ADCP2
F2 (-/-)
29
CD20
CD20,CVID5,LEU-16
F1 (+/-)
24
ADORA2A
A2aR,RDC8,ADORA2
F0
20
ALB
ALB
F1 (+/-)
15
FLT3
FLT3,FLK2,CD135
F1 (+/-)
10
IL11RA
IL11RA,CRSDA
F0
9
PD-1
PD1
In Vitro
8
APP
APP,PN2,CTFgamma
F0
8
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Inflammation and Autoimmunity
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
G-CSFR
G-CSFR
F0
96
TNF
TNF,TNFA,TNFSF2
F0
49
CD26
CD26,ADABP,ADCP2
F2 (-/-)
29
CD20
CD20,CVID5,LEU-16
F1 (+/-)
24
ALB
ALB
F1 (+/-)
15
FLT3
FLT3,FLK2,CD135
F1 (+/-)
10
APP
APP,PN2,CTFgamma
F0
8
CD19
CD19,B4,CVID3
F0
6
IFNG
IFNG,IFG,IFI
F1 (+/-)
5
IL6
IL-6,BSF-2,IFNB2
F1 (+/-)
5
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Infectious Diseases
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
TNF
TNF,TNFA,TNFSF2
F0
49
IL11RA
IL11RA,CRSDA
F0
9
APP
APP,PN2,CTFgamma
F0
8
IFNG
IFNG,IFG,IFI
F1 (+/-)
5
C5a
C5a,C5b,ECLZB
F0
2
CCR5
CKR5,CD195,CCR5
F0
1
TLR3
TLR3,CD283,IIAE2
F0
1
MMP-9
MMP-9
F0
1
TLR4
TLR4
F0
1
TLR2
TLR2
F0
1
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Neuroscience
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
APP
APP,PN2,CTFgamma
F0
8
PSMA
PSMA,FGCP,FOLH1
F0
2
PAR2
PAR2, GPR11
F0
CGRP
CGRP,CALC1,CGRP1
F0
0
CLEC14A
CEG1, EGFR-5, C14orf27
F0
CRCP
CRCP,CGRPRCP
F0
IL12
IL12
F0
LEPR
LEPR,OBR,CD295
F0
MFGE8
MFGE8,BA46,HMFG,
F0
LINGO-1
LINGO-1
F0
0
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Cardiovascular
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
G-CSFR
G-CSFR
F0
96
APP
APP,PN2,CTFgamma
F0
8
UPA
UPA
F0
2
PCSK9
PCSK9
F0
2
CD106
CD106,VCAM1
F1 (+/-)
1
CD62P
CD62P,GRMP,SELP
F0
1
ADAMTS1
ADAMTS1,C3-C5,METH1
F0
SERPINF2
SERPINF2,AAP,API
F0
CD49b
CD49b,HPA-5,VLA-2
F0
0
5HT2AR
HTR2, 5-HT2A
F0
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Metabolism
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
GLP1R
GLP1R,GLP-1
F1 (+/-)
12
APP
APP,PN2,CTFgamma
F0
8
GCGR
GCGR
Immunization
5
CB1
CB1
Immunization
2
PCSK9
PCSK9
F0
2
RANKL
RANKL,OPGL,TNFSF11
F0
1
CD6
CD6,TP120
F0
1
FFAR1
FFA1R, GPCR40, GPR40
F0
0
FGF21
FGF21
F0
0
ADIPOR1
ADIPOR1
F0
0
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Orthopaedic Disorders
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
Sclerostin
SOST
F0
1
RANKL
RANKL,OPGL,TNFSF11
F0
1
SPARC
SPARC,ONT,BM-40
F0
KLKB1
KLKB1,PKK,KLK3
F0
ADAMTS4
ADAMTS4,ADMP-1,ADAMTS-2
F0
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Ophthalmology
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
APP
APP,PN2,CTFgamma
F0
8
CD160
CD160,NK1,BY55,NK28
F0
ROBO4
ROBO4,AOVD3,ECSM4
F1 (+/-)
0
CFD
CFD,DF,ADIPSIN
F0
CNGB1
CNGB1,GARP2
F0
CLEC14A
CEG1, EGFR-5, C14orf27
F0
LRP5
LRP5,HBM,LR3
F0
LINGO-1
LINGO-1
F0
0
MFGE8
MFGE8,BA46,HMFG,
F0
MASP2
MASP2,sMAP,MAP19
F0
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Urological Diseases
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
IFNAR1
IFNAR1,AVP,IFNBR
F0
4
CFB
CFB,PBF2,AHUS4
F0
0
GAS6
GAS6,AXSF,AXLLG
F0
EREG
EREG,ER,Ep,EPR
F0
CFD
CFD,DF,ADIPSIN
F0
EDA1
EDA1,HED,TNLG7C
F0
APRIL
APRIL,CD256,TALL2
F0
0
MASP2
MASP2,sMAP,MAP19
F0
RAGE
RAGE, SCARJ1
F0
0
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Reproductive System Diseases
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
PRLR
PRLR,HPRL,MFAB
F0
0
ANXA1
ANXA1,ANX1,LPC1
F0
CD205
CD205,LY-75,CLEC13B
F0
0
CD160
CD160,NK1,BY55,NK28
F0
EDA1
EDA1,HED,TNLG7C
F0
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Gastrointestinal
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
TLR4
TLR4
F0
1
TLR2
TLR2
F0
1
TREM2
TREM2,PLOSL2
F0
CD48
CD48,BCM1,BLAST
F0
0
IL20R1
IL20R1,CRF2-8,IL-20R1
F0
CCL20
CCL20,CKb4,LARC
F0
0
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Others
- Target Name
- Target Aliases
- KO Status/Phase
- Launched Drugs
G-CSFR
G-CSFR
F0
96
APP
APP,PN2,CTFgamma
F0
8
UPA
UPA
F0
2
IL3RA
IL3RA,IL3R,CD123
F0
1
MMP-9
MMP-9
F0
1
CD31
CD31,PECA1,PECAM-1
F0
KLKB1
KLKB1,PKK,KLK3
F0
SERPINF2
SERPINF2,AAP,API
F0
CFB
CFB,PBF2,AHUS4
F0
0
CXCL4
CXCL4,PF-4,CXCL4
F0