ADORA2A

Synonyms

Adenosine receptor A2a, ADORA2A, Adenosine A2a Receptor, ADORA2, Adenosine Receptor Subtype A2a, A2aR, RDC8, Receptor, Adenosine A2A

Description

Adenosine A2a receptor, also known as ADORA2A, is an adenosine receptor. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

KO Status

F1 (+/-)

Drug Information

Launched drugs: 16
Drugs in clinical trials: 13
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Caffeine/Ergotamine Tartrate

Approved

Novartis Pharma Ag

Migraine Disorders

Aspirin/Acetaminophen/Caffeine/Chlorphenamine Maleate

Approved

Common Cold

Aminophenazone/Caffeine/Chlorphenamine Maleate

Approved

Headache, Common Cold, Neuralgia

Acetaminophen/Caffeine/Chlorphenamine Maleate

Approved

Common Cold

Acetaminophen/Pseudoephedrine Hydrochloride/Caffeine

Approved

Common Cold

Acetaminophen/Caffeine/Pseudoephedrine Hydrochloride/Chlorphenamine Maleate

Approved

Common Cold

Aminophenazone/Phenacetin/Caffeine/Phenobarbital

Approved

Migraine Disorders

Aspirin/Caffeine/Chlorphenamine Maleate/Tartaric Acid

Approved

Common Cold

Acetaminophen/Chlorphenamine Maleate/Caffeine/Guaifenesin

Approved

Common Cold

Aminophenazone/Phenacetin/Caffeine

Approved

Pain, Fever

References


Title

Authors

Source

Molecular characterization of a human brain adenosine A2 receptor

Furlong T.J., Pierce K.D., Selbie L.A., Shine J.,

Brain Res. Mol. Brain Res. 15:62-66(1992)

Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A

Le F., Townsend-Nicholson A., Baker E., Sutherland G.R., Schofield P.R.,

Biochem. Biophys. Res. Commun. 223:461-467(1996)

A genome annotation-driven approach to cloning the human ORFeome

Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.,

Genome Biol. 5:R84.1-R84.11(2004)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor

Canela L., Lujan R., Lluis C., Burgueno J., Mallol J., Canela E.I., Franco R., Ciruela F.,

Mol. Cell. Neurosci. 36:1-12(2007)

The dopamine D(4) receptor, the ultimate disordered protein

Woods A.S.,

J. Recept. Signal Transduct. 30:331-336(2010)

Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor

Kim J., Wess J., van Rhee A.M., Schoneberg T., Jacobson K.A.,

J. Biol. Chem. 270:13987-13997(1995)

The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor

Milojevic T., Reiterer V., Stefan E., Korkhov V.M., Dorostkar M.M., Ducza E., Ogris E., Boehm S., Freissmuth M., Nanoff C.,

Mol. Pharmacol. 69:1083-1094(2006)

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

Jaakola V.-P., Griffith M.T., Hanson M.A., Cherezov V., Chien E.Y.T., Lane J.R., Ijzerman A.P., Stevens R.C.,

Science 322:1211-1217(2008)