APRIL

Synonyms

TNF- and APOL-related leukocyte expressed ligand 2, TNFSF13, TNF-related death ligand 1, ZTNF2, TALL-2, APRIL, Tumor necrosis factor ligand superfamily member 13, TNF Superfamily Member 13, Tumor Necrosis Factor (Ligand) Superfamily, Member 13, TRDL-1, TALL2, Tumor Necrosis Factor Superfamily Member 13, Tumor Necrosis Factor-Like Protein ZTNF2, Tumor Necrosis Factor Ligand 7B, CD256 Antigen, TNLG7B, CD256, A Proliferation-Inducing Ligand, Tumor Necrosis Factor-Related Death Ligand-1, UNQ383/PRO715

Description

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

KO Status

F0

Drug Information

Drugs in clinical trials: 7
Latest Research Phase: NDA/BLA

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Telitacicept

RCT-18, RC-18, RCT18, RC18

Approved

Rc Biotechnologies Ltd

Multiple Sclerosis, Relapsing-Remitting, Myasthenia Gravis, Glomerulonephritis, IGA, Sjogren's Syndrome, Arthritis, Rheumatoid, Multiple Sclerosis, Lupus Erythematosus, Systemic, Neuromyelitis Optica

Atacicept

TACI-Ig

Phase 3 Clinical

Zymogenetics

Glomerulonephritis, IGA, Arthritis, Rheumatoid, Lupus Nephritis, Multiple Sclerosis, Multiple Myeloma, Optic Neuritis, Lupus Erythematosus, Systemic, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

BION-1301

BION-1301

Phase 2 Clinical

Aduro Biotech

Glomerulonephritis, IGA, Multiple Myeloma

VIS-649

VIS-649

Phase 2 Clinical

Visterra

Glomerulonephritis, IGA, Glomerulonephritis

BCMAxCD3 bispecific antibody (Regeneron)

REGN-5458

Phase 2 Clinical

Regeneron Pharmaceuticals Inc

Multiple Myeloma

APRIL CAR-T Cell therapy (Yake Biotechnology)

Phase 1 Clinical

Yake Biotechnology Ltd

Multiple Myeloma

bb-21217

bb-21217

Phase 1 Clinical

Bluebird Bio

Multiple Myeloma

Anti-BCMA CAR T-cell therapy (Huazhong University of Science and Technology)

Clinical

Huazhong University Of Science And Technology

Multiple Myeloma

References


Title

Authors

Source

APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death

Kelly K.A., Manos E.J., Jensen G.T., Nadauld L., Jones D.A.,

Cancer Res. 60:1021-1027(2000)

An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein

Pradet-Balade B., Medema J.P., Lopez-Fraga M., Lozano J.C., Kolfschoten G.M., Picard A., Martinez-A C., Garcia-Sanz J.A., Hahne M.,

EMBO J. 21:5711-5720(2002)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment

Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,

Genome Res. 13:2265-2270(2003)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage

Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L., Nusbaum C.,

Nature 440:1045-1049(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity

Yu G., Boone T., Delaney J., Hawkins N., Kelley M.J., Ramakrishnan M., McCabe S., Qiu W.R., Kornuc M., Xia X.-Z., Guo J., Stolina M., Boyle W.J., Sarosi I., Hsu H., Senaldi G., Theill L.E.,

Nat. Immunol. 1:252-256(2000)

Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase

Lopez-Fraga M., Fernandez R., Albar J.P., Hahne M.,

EMBO Rep. 2:945-951(2001)

APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth

Hahne M., Kataoka T., Schroeter M., Hofmann K., Irmler M., Bodmer J.-L., Schneider P., Bornand T., Holler N., French L.E., Sordat B., Rimoldi D., Tschopp J.,

J. Exp. Med. 188:1185-1190(1998)

TALL-1 is a novel member of the TNF family that is down-regulated by mitogens

Shu H.-B., Hu W.-H., Johnson H.,

J. Leukoc. Biol. 65:680-683(1999)