APRIL

Synonyms

TNF- and APOL-related leukocyte expressed ligand 2, TNFSF13, TNF-related death ligand 1, ZTNF2, TALL-2, APRIL, Tumor necrosis factor ligand superfamily member 13, TNF Superfamily Member 13, Tumor Necrosis Factor (Ligand) Superfamily, Member 13, TRDL-1, TALL2, Tumor Necrosis Factor Superfamily Member 13, Tumor Necrosis Factor-Like Protein ZTNF2, Tumor Necrosis Factor Ligand 7B, CD256 Antigen, TNLG7B, CD256, A Proliferation-Inducing Ligand, Tumor Necrosis Factor-Related Death Ligand-1, UNQ383/PRO715,

Description

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

KO Status

F0

Drug Information

Launched drugs: 7
Drugs in clinical trials: 0
Latest Research Phase:NDA/BLA

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Telitacicept

RCT-18, RC-18, RCT18, RC18

NDA/BLA

Rc Biotechnologies Ltd

Myasthenia Gravis, Multiple Sclerosis, Relapsing-Remitting, Nephrosis, Glomerulonephritis, IGA, Arthritis, Rheumatoid, Sjogren's Syndrome, Neuromyelitis Optica, Lupus Erythematosus, Systemic

Atacicept

TACI-Ig

Phase 3 Clinical

Zymogenetics

Glomerulonephritis, IGA, Arthritis, Rheumatoid, Multiple Sclerosis, Optic Neuritis, Lupus Nephritis, Multiple Myeloma, Lupus Erythematosus, Systemic, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

BION-1301

BION-1301

Phase 2 Clinical

Aduro Biotech

Glomerulonephritis, IGA, Multiple Myeloma

VIS-649

VIS-649

Phase 2 Clinical

Visterra

Glomerulonephritis, IGA, Glomerulonephritis

BCMAxCD3 bispecific antibody (Regeneron)

REGN-5458

Phase 2 Clinical

Regeneron Pharmaceuticals Inc

Multiple Myeloma

bb-21217

bb-21217

Phase 1 Clinical

Bluebird Bio

Multiple Myeloma

Anti-BCMA CAR T-cell therapy (Huazhong University of Science and Technology)

Clinical

Huazhong University Of Science And Technology

Multiple Myeloma