DTL, Dendritic Cell-Derived TNF-Like Molecule, CD257, B-Cell-Activating Factor, B Lymphocyte Stimulator, B-Lymphocyte Stimulator, B-Cell Activating Factor, Tumor Necrosis Factor Ligand 7A, TNF And ApoL-Related Leukocyte Expressed Ligand 1, BAFF, BLYS, Delta BAFF, TALL-1, Epididymis Secretory Sperm Binding Protein, ApoL Related Ligand TALL-1, TNF Superfamily Member 13b, Tumor Necrosis Factor-Like Protein ZTNF4, Delta4 BAFF, THANK, TNF- And APOL-Related Leukocyte Expressed Ligand 1, Tumor Necrosis Factor Ligand Superfamily Member 13B, TALL1, TNLG7A, ZTNF4, Tumor Necrosis Factor (Ligand) Superfamily, Member 20, CD257 Antigen, Tumor Necrosis Factor Superfamily Member 13b, TNFSF20, TNFSF13B, TNF Homolog That Activates Apoptosis, Tumor Necrosis Factor (Ligand) Superfamily, Member 13b


Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

KO Status


Drug Information

Launched drug: 1
Drugs in clinical trials: 6
Latest Research Phase: Approved

Drug Name





Clinical Trials


GSK-1550188, HGS-1006, BmAb


Glaxosmithkline Plc

Arthritis, Rheumatoid, Vasculitis, Purpura, Lupus Nephritis, Glomerulonephritis, Membranous, Lupus Erythematosus, Systemic


RCT-18, RC-18, RCT18, RC18


Rc Biotechnologies Ltd

Multiple Sclerosis, Relapsing-Remitting, Myasthenia Gravis, Glomerulonephritis, IGA, Arthritis, Rheumatoid, Sjogren's Syndrome, Multiple Sclerosis, Lupus Erythematosus, Systemic, Neuromyelitis Optica



Phase 3 Clinical


Glomerulonephritis, IGA, Arthritis, Rheumatoid, Optic Neuritis, Multiple Sclerosis, Lupus Nephritis, Multiple Myeloma, Lupus Erythematosus, Systemic, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Rozibafusp alfa

AMG-570, MEDI-0700

Phase 2 Clinical

Amgen Inc

Arthritis, Rheumatoid, Lupus Erythematosus, Systemic



Phase 1 Clinical

Wuhan Huaxin Kangyuan Biomedicine Co Ltd, Shanghai Junshi Biosciences Co Ltd

Lupus Erythematosus, Systemic

Tibulizumab (Eli Lilly)

LY-3090106, LY3090106


Eli Lilly And Company

Sjogren's Syndrome

Mitumprotimut T



Lymphoma, Follicular, Lymphoma, Non-Hodgkin




Eli Lilly And Company

Multiple Sclerosis, Relapsing-Remitting, Renal Insufficiency, Arthritis, Rheumatoid, Autoimmune Diseases, Multiple Sclerosis, Multiple Myeloma, Connective Tissue Diseases, Lupus Erythematosus, Systemic, Kidney Failure, Chronic


A-623, AMG-623



Purpura, Thrombocytopenic, Idiopathic, Granulomatosis with Polyangiitis, Glomerulonephritis, IGA, Microscopic Polyangiitis, Lupus Erythematosus, Systemic




Biogen Inc






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