BAFF

Synonyms

DTL, Dendritic Cell-Derived TNF-Like Molecule, CD257, B-Cell-Activating Factor, B Lymphocyte Stimulator, B-Lymphocyte Stimulator, B-Cell Activating Factor, Tumor Necrosis Factor Ligand 7A, TNF And ApoL-Related Leukocyte Expressed Ligand 1, BAFF, BLYS, Delta BAFF, TALL-1, Epididymis Secretory Sperm Binding Protein, ApoL Related Ligand TALL-1, TNF Superfamily Member 13b, Tumor Necrosis Factor-Like Protein ZTNF4, Delta4 BAFF, THANK, TNF- And APOL-Related Leukocyte Expressed Ligand 1, Tumor Necrosis Factor Ligand Superfamily Member 13B, TALL1, TNLG7A, ZTNF4, Tumor Necrosis Factor (Ligand) Superfamily, Member 20, CD257 Antigen, Tumor Necrosis Factor Superfamily Member 13b, TNFSF20, TNFSF13B, TNF Homolog That Activates Apoptosis, Tumor Necrosis Factor (Ligand) Superfamily, Member 13b

Description

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

KO Status

F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 6
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Belimumab

GSK-1550188, HGS-1006, BmAb

Approved

Glaxosmithkline Plc

Arthritis, Rheumatoid, Vasculitis, Purpura, Lupus Nephritis, Glomerulonephritis, Membranous, Lupus Erythematosus, Systemic

Telitacicept

RCT-18, RC-18, RCT18, RC18

Approved

Rc Biotechnologies Ltd

Multiple Sclerosis, Relapsing-Remitting, Myasthenia Gravis, Glomerulonephritis, IGA, Arthritis, Rheumatoid, Sjogren's Syndrome, Multiple Sclerosis, Lupus Erythematosus, Systemic, Neuromyelitis Optica

Atacicept

TACI-Ig

Phase 3 Clinical

Zymogenetics

Glomerulonephritis, IGA, Arthritis, Rheumatoid, Optic Neuritis, Multiple Sclerosis, Lupus Nephritis, Multiple Myeloma, Lupus Erythematosus, Systemic, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Rozibafusp alfa

AMG-570, MEDI-0700

Phase 2 Clinical

Amgen Inc

Arthritis, Rheumatoid, Lupus Erythematosus, Systemic

UBP-1213

UBP-1213

Phase 1 Clinical

Wuhan Huaxin Kangyuan Biomedicine Co Ltd, Shanghai Junshi Biosciences Co Ltd

Lupus Erythematosus, Systemic

Tibulizumab (Eli Lilly)

LY-3090106, LY3090106

Pending

Eli Lilly And Company

Sjogren's Syndrome

Mitumprotimut T

Discontinued

Mmrglobal

Lymphoma, Follicular, Lymphoma, Non-Hodgkin

Tabalumab

LY-2127399

Discontinued

Eli Lilly And Company

Multiple Sclerosis, Relapsing-Remitting, Renal Insufficiency, Arthritis, Rheumatoid, Autoimmune Diseases, Multiple Sclerosis, Multiple Myeloma, Connective Tissue Diseases, Lupus Erythematosus, Systemic, Kidney Failure, Chronic

Blisibimod

A-623, AMG-623

Discontinued

Anthera

Purpura, Thrombocytopenic, Idiopathic, Granulomatosis with Polyangiitis, Glomerulonephritis, IGA, Microscopic Polyangiitis, Lupus Erythematosus, Systemic

hCBE-11

hCBE-11

Discontinued

Biogen Inc

Neoplasms

References


Title

Authors

Source

TALL-1 is a novel member of the TNF family that is down-regulated by mitogens

Shu H.-B., Hu W.-H., Johnson H.,

J. Leukoc. Biol. 65:680-683(1999)

BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.-L., Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H., Valmori D., Romero P., Werner-Favre C., Zubler R.H., Browning J.L., Tschopp J.,

J. Exp. Med. 189:1747-1756(1999)

BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator

Moore P.A., Belvedere O., Orr A., Pieri K., LaFleur D.W., Feng P., Soppet D., Charters M., Gentz R., Parmelee D., Li Y., Galperina O., Giri J., Roschke V., Nardelli B., Carrell J., Sosnovtseva S., Greenfield W., Hilbert D.M.,

Science 285:260-263(1999)

DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF

Gavin A.L., Ait-Azzouzene D., Ware C.F., Nemazee D.,

J. Biol. Chem. 278:38220-38228(2003)

The complexity of the BAFF TNF-family members: implications for autoimmunity

Lahiri A., Pochard P., Le Pottier L., Tobon G.J., Bendaoud B., Youinou P., Pers J.O.,

J. Autoimmun. 39:189-198(2012)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment

Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,

Genome Res. 13:2265-2270(2003)

The DNA sequence and analysis of human chromosome 13

Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ross M.T.,

Nature 428:522-528(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity

Yu G., Boone T., Delaney J., Hawkins N., Kelley M.J., Ramakrishnan M., McCabe S., Qiu W.R., Kornuc M., Xia X.-Z., Guo J., Stolina M., Boyle W.J., Sarosi I., Hsu H., Senaldi G., Theill L.E.,

Nat. Immunol. 1:252-256(2000)

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands

Liu Y., Xu L., Opalka N., Kappler J., Shu H.-B., Zhang G.,

Cell 108:383-394(2002)