BAFF

Synonyms

Dendritic Cell-Derived TNF-Like Molecule, B-Cell-Activating Factor, CD257, Epididymis Secretory Sperm Binding Protein, Tumor Necrosis Factor-Like Protein ZTNF4, Delta4 BAFF, BAFF, THANK, BLYS, ApoL Related Ligand TALL-1, TNF Superfamily Member 13b, Delta BAFF, TALL-1, Tumor Necrosis Factor Ligand 7A, B-Cell Activating Factor, B Lymphocyte Stimulator, B-Lymphocyte Stimulator, TNF And ApoL-Related Leukocyte Expressed Ligand 1, ZTNF4, Tumor Necrosis Factor (Ligand) Superfamily, Member 20, TNF- And APOL-Related Leukocyte Expressed Ligand 1, Tumor Necrosis Factor Ligand Superfamily Member 13B, TALL1, TNLG7A, TNF Homolog That Activates Apoptosis, CD257 Antigen, TNFSF20, Tumor Necrosis Factor (Ligand) Superfamily, Member 13b, Tumor Necrosis Factor Superfamily Member 13b, TNFSF13B, DTL

KO Status

RenMab: Immunization

Drug Information

Launched drugs: 2
Drugs in clinical trials: 3
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Belimumab

GSK-1550188, HGS-1006, BmAb

Approved

Glaxosmithkline Plc

Arthritis, Rheumatoid, Purpura, Lupus Nephritis, Glomerulonephritis, Membranous, Lupus Erythematosus, Systemic

Telitacicept

RCT-18, RC-18, RCT18, RC18

Approved

RemeGen Co Ltd

Multiple Sclerosis, Relapsing-Remitting, Myasthenia Gravis, Glomerulonephritis, IGA, Arthritis, Rheumatoid, Sjogren's Syndrome, Multiple Sclerosis, Lupus Erythematosus, Systemic, Neuromyelitis Optica

Atacicept

TACI-Ig

Phase 3 Clinical

Zymogenetics

Glomerulonephritis, IGA, Arthritis, Rheumatoid, Optic Neuritis, Multiple Sclerosis, Lupus Nephritis, Multiple Myeloma, Lupus Erythematosus, Systemic, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Rozibafusp alfa

AMG-570, MEDI-0700

Phase 2 Clinical

Amgen Inc

Arthritis, Rheumatoid, Lupus Erythematosus, Systemic

UBP-1213

UBP-1213

Phase 1 Clinical

Wuhan Huaxin Kangyuan Biomedicine Co Ltd, Shanghai Junshi Biosciences Co Ltd

Lupus Erythematosus, Systemic

Tibulizumab (Eli Lilly)

LY-3090106, LY3090106

Pending

Eli Lilly And Company

Sjogren's Syndrome

hCBE-11

hCBE-11

Discontinued

Biogen Inc

Neoplasms

Mitumprotimut T

Discontinued

Mmrglobal

Lymphoma, Follicular, Lymphoma, Non-Hodgkin

Tabalumab

LY-2127399

Discontinued

Eli Lilly And Company

Multiple Sclerosis, Relapsing-Remitting, Renal Insufficiency, Arthritis, Rheumatoid, Autoimmune Diseases, Multiple Sclerosis, Multiple Myeloma, Connective Tissue Diseases, Lupus Erythematosus, Systemic, Kidney Failure, Chronic

Blisibimod

A-623, AMG-623

Discontinued

Anthera

Purpura, Thrombocytopenic, Idiopathic, Granulomatosis with Polyangiitis, Glomerulonephritis, IGA, Microscopic Polyangiitis, Lupus Erythematosus, Systemic

References


Title

Authors

Source

TALL-1 is a novel member of the TNF family that is down-regulated by mitogens

Shu H.-B., Hu W.-H., Johnson H.,

J. Leukoc. Biol. 65:680-683(1999)

BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.-L., Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H., Valmori D., Romero P., Werner-Favre C., Zubler R.H., Browning J.L., Tschopp J.,

J. Exp. Med. 189:1747-1756(1999)

BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator

Moore P.A., Belvedere O., Orr A., Pieri K., LaFleur D.W., Feng P., Soppet D., Charters M., Gentz R., Parmelee D., Li Y., Galperina O., Giri J., Roschke V., Nardelli B., Carrell J., Sosnovtseva S., Greenfield W., Hilbert D.M.,

Science 285:260-263(1999)

DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF

Gavin A.L., Ait-Azzouzene D., Ware C.F., Nemazee D.,

J. Biol. Chem. 278:38220-38228(2003)

The complexity of the BAFF TNF-family members: implications for autoimmunity

Lahiri A., Pochard P., Le Pottier L., Tobon G.J., Bendaoud B., Youinou P., Pers J.O.,

J. Autoimmun. 39:189-198(2012)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment

Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,

Genome Res. 13:2265-2270(2003)

The DNA sequence and analysis of human chromosome 13

Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ross M.T.,

Nature 428:522-528(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity

Yu G., Boone T., Delaney J., Hawkins N., Kelley M.J., Ramakrishnan M., McCabe S., Qiu W.R., Kornuc M., Xia X.-Z., Guo J., Stolina M., Boyle W.J., Sarosi I., Hsu H., Senaldi G., Theill L.E.,

Nat. Immunol. 1:252-256(2000)

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands

Liu Y., Xu L., Opalka N., Kappler J., Shu H.-B., Zhang G.,

Cell 108:383-394(2002)