CCL20

Synonyms

Chemokine CCL20, Exodus-1, ST38, Chemokine (C-C Motif) Ligand 20, CCL20, LARC, C-C motif chemokine 20, SCYA20, MIP-3-alpha, C-C Motif Chemokine Ligand 20, Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20, Liver And Activation-Regulated Chemokine, Macrophage Inflammatory Protein 3 Alpha, MIP-3a, CKb4, Small-Inducible Cytokine A20, CC Chemokine LARC, MIP3A, Beta Chemokine Exodus-1, Beta-Chemokine Exodus-1, Exodus

KO Status

F0

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

GSK-3050002

E-6071, KANAb-071, GSK-3050002

Discontinued

Glaxosmithkline Plc, Morphotek

Autoimmune Diseases, Colitis, Ulcerative, Arthritis, Psoriatic

References


Title

Authors

Source

The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins

Hoover D.M., Boulegue C., Yang D., Oppenheim J.J., Tucker K., Lu W., Lubkowski J.,

J. Biol. Chem. 277:37647-37654(2002)

Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2

Hieshima K., Imai T., Opdenakker G., van Damme J., Kusuda J., Tei H., Sakaki Y., Takatsuki K., Miura R., Yoshie O., Nomiyama H.,

J. Biol. Chem. 272:5846-5853(1997)

Cloning and characterization of Exodus, a novel beta-chemokine

Hromas R.A., Gray P.W., Chantry D., Godiska R., Krathwohl M., Fife K., Bell G.I., Takeda J., Aronica S., Gordon M., Cooper S., Broxmeyer H.E., Klemsz M.J.,

Blood 89:3315-3322(1997)

Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization

Nelson R.T., Boyd J., Gladue R.P., Paradis T., Thomas R., Cunningham A.C., Lira P., Brissette W.H., Hayes L., Hames L.M., Neote K.S., McColl S.R.,

Genomics 73:28-37(2001)

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,

Nature 434:724-731(2005)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells

Schutyser E., Struyf S., Menten P., Lenaerts J.-P., Conings R., Put W., Wuyts A., Proost P., Van Damme J.,

J. Immunol. 165:4470-4477(2000)

Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells

Roehrl J., Yang D., Oppenheim J.J., Hehlgans T.,

J. Biol. Chem. 285:7028-7034(2010)

CCR6 as a mediator of immunity in the lung and gut

Ito T., Carson W.F. IV, Cavassani K.A., Connett J.M., Kunkel S.L.,

Exp. Cell Res. 317:613-619(2011)

A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis

Caballero-Campo P., Buffone M.G., Benencia F., Conejo-Garcia J.R., Rinaudo P.F., Gerton G.L.,

J. Cell. Physiol. 229:68-78(2014)