CD19

Synonyms

CD19, T-cell surface antigen Leu-12, Differentiation antigen CD19, CD19 Molecule, B-Lymphocyte Surface Antigen B4, CD19 Antigen, B-Lymphocyte Antigen CD19, CVID3, B4, Antigens, CD19,

Description

B-lymphocyte antigen CD19 functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. CD19 decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. CD19 activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca stores. And it is required for normal differentiation of B-1 cells, normal B cell differentiation and proliferation in response to antigen challenges, normal levels of serum immunoglobulins and for production of high-affinity antibodies in response to antigen challenge.

KO Status

F0

Drug Information

Launched drugs: 159
Drugs in clinical trials: 6
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

CD19-CART (PD-1 knockdown, Unicar-Therapy Bio-medicine Technology)

IND

Shanghai Unicar-Therapy Bio-Medicine Technology Co Ltd

Lymphoma

UBG-T19

Preclinical

Guangzhou Baiji Gene Technology Co Ltd

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

HY-003

HY-003

Preclinical

Heyuan Biotechnology (Tianjin) Co Ltd

Relmacabtagene autoleucel

JWCAR-029

NDA/BLA

Suzhou Yaomingjunuo Biotechnology Co Ltd

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin

Chimeric antigen receptor-modified autologous T cell injection targeting CD19 (Bio-gene)

BG-T19

IND

Guangzhou Baiji Gene Technology Co Ltd

Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Tisagenlecleucel

LG-740, CART-19, CTL-019, CART-019

Approved

University Of Pennsylvania, Novartis Pharma Ag

Lymphoma, Large B-Cell, Diffuse, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin

Loncastuximab tesirine

ADCT-402

NDA/BLA

Adc Therapeutics

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Lymphoma, Follicular, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Burkitt Lymphoma, Lymphoma, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Leukemia, Lymphocytic, Chronic, B-Cell

Brexucabtagene autoleucel

KTE-X19

Approved

Kite Pharma Inc

Lymphoma, Mantle-Cell

B-193

B-193

Preclinical

Shanghai Yanyi Biotechnology

Neoplasms

FKC-876

FKC-876

NDA/BLA

Fosun Kate Biotechnology Co Ltd

Lymphoma, B-Cell

RD-301

Preclinical

Nanjing Iaso Biotherapeutics Co Ltd

Precursor Cell Lymphoblastic Leukemia-Lymphoma

CD19/CD3

Preclinical

Wuhan Yzy Biopharma

Lymphoma

Axicabtagene ciloleucel

KTE-C19, KTE C19

Approved

Cabaret Biotech

Lymphoma, B-Cell, Recurrence, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Precursor Cell Lymphoblastic Leukemia-Lymphoma

Lisocabtagene maraleucel (Celgene/Juno Therapeutics)

JCAR-017, Liso-Cel

NDA/BLA

Fred Hutchinson Cancer Research Center, Juno Therapeutics, Seattle Children'S Research Institute, Memorial Sloan Kettering Cancer Center

Lymphoma, B-Cell, Lymphatic Diseases, Immunoproliferative Disorders, Neoplasms by Histologic Type, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoproliferative Disorders, Lymphoma, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

因诺卡替-19细胞

IND

Shenzhen Inno Immunization Co Ltd

Leukemia, Lymphoid

ICTCAR003

ICTCAR003

IND

Sidansai Biotechnology Co Ltd

Leukemia, Biphenotypic, Acute

HY-004 (Juventas)

HY-004 (Juventas)

Preclinical

Heyuan Biotechnology (Tianjin) Co Ltd

Precursor Cell Lymphoblastic Leukemia-Lymphoma

EBV-CTL (Atara/MSKCC)

EBV-CTL-Atara-MSKCC

Preclinical

Memorial Sloan Kettering Cancer Center

Lymphoproliferative Disorders

Inebilizumab

MEDI-551, 16C4-aFuc

Approved

Medimmune

Myasthenia Gravis, Recurrence, Lymphoma, B-Cell, Hematologic Neoplasms, Lymphoma, Large B-Cell, Diffuse, Scleroderma, Systemic, Multiple Sclerosis, Neuromyelitis Optica, Scleroderma, Localized, Leukemia, Lymphocytic, Chronic, B-Cell

Tafasitamab

XmAb-5574, MOR-208, XENP-5574, MOR-00208

Approved

Xencor

Lymphoma, Large B-Cell, Diffuse, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell