CD19

Synonyms

CD19, T-cell surface antigen Leu-12, Differentiation antigen CD19, CD19 Molecule, B-Lymphocyte Surface Antigen B4, CD19 Antigen, B-Lymphocyte Antigen CD19, CVID3, B4, Antigens, CD19

Description

B-lymphocyte antigen CD19 functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. CD19 decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. CD19 activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca stores. And it is required for normal differentiation of B-1 cells, normal B cell differentiation and proliferation in response to antigen challenges, normal levels of serum immunoglobulins and for production of high-affinity antibodies in response to antigen challenge.

KO Status

F0

Drug Information

Launched drugs: 6
Drugs in clinical trials: 159
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Inebilizumab

16C4-aFuc, MEDI-551, MT-0551, VIB-0551

Approved

Duke University

Myasthenia Gravis, Lymphoma, B-Cell, Hematologic Neoplasms, Rejection of renal transplantation, Immunoglobulin G4-Related Disease, Lymphoma, Large B-Cell, Diffuse, Scleroderma, Systemic, Multiple Sclerosis, Neuromyelitis Optica, Leukemia, Lymphocytic, Chronic, B-Cell

Anti-BCMA/CD19 CAR-T(Autolus)

CTA-30X

CTA-30X, CTA30X

Axicabtagene ciloleucel

KTE-C19, KTE C19

Approved

Cabaret Biotech

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Precursor Cell Lymphoblastic Leukemia-Lymphoma

CD19/CD22 bispecific CAR-T (Zhejiang University)

Blinatumomab

MT-103, MEDI-538, BiTE-MT-103, bscCD19xCD3, AMG-103

Approved

Amgen Inc

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin, Burkitt Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell

YTB-323

YTB-323

Novartis Pharma Ag

CD19/CD20 CAR-T Cell Therapy (PersonGen)

Tisagenlecleucel

LG-740, CART-19, CTL-019, CART-019

Approved

University Of Pennsylvania, Novartis Pharma Ag

Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin

CD19 CAR engineered autologous T-cells(Sabz Biomedicals)

References


Title

Authors

Source

Regulatory role of CD19 molecules in B-cell activation and differentiation

de Rie M.A., Schumacher T.N., van Schijndel G.M., van Lier R.A., Miedema F.,

Cell. Immunol. 118:368-381(1989)

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19

Matsumoto A.K., Kopicky-Burd J., Carter R.H., Tuveson D.A., Tedder T.F., Fearon D.T.,

J. Exp. Med. 173:55-64(1991)

CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail

Stamenkovic I., Seed B.,

J. Exp. Med. 168:1205-1210(1988)

Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily

Tedder T.F., Isaacs C.M.,

J. Immunol. 143:712-717(1989)

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M.,

Mol. Cell. Biol. 12:2662-2672(1992)

Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes

Zhou L.J., Ord D.C., Omori S.A., Tedder T.F.,

Immunogenetics 35:102-111(1992)

Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese

Kuroki K., Tsuchiya N., Tsao B.P., Grossman J.M., Fukazawa T., Hagiwara K., Kano H., Takazoe M., Iwata T., Hashimoto H., Tokunaga K.,

Genes Immun. 3:S21-S30(2002)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The sequence and analysis of duplication-rich human chromosome 16

Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Pennacchio L.A.,

Nature 432:988-994(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)