CD19

Synonyms

Differentiation antigen CD19, CD19 Molecule, B-Lymphocyte Surface Antigen B4, CD19 Antigen, B-Lymphocyte Antigen CD19, CVID3, B4, Antigens, CD19, CD19, T-cell surface antigen Leu-12

Description

B-lymphocyte antigen CD19 functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. CD19 decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. CD19 activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca stores. And it is required for normal differentiation of B-1 cells, normal B cell differentiation and proliferation in response to antigen challenges, normal levels of serum immunoglobulins and for production of high-affinity antibodies in response to antigen challenge.

KO Status

RenMab: F0

RenLite: F0

Drug Information

Launched drugs: 9
Drugs in clinical trials: 181
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Tafasitamab

XmAb-5574, MOR-208, XENP-5574, MOR-00208

Approved

Xencor

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

CAR-20-19-22(Medical College of Wisconsin)

CAR-20-19-22

The Medical College Of Wisconsin Nonprofit

Axicabtagene ciloleucel

KTE-C19, KTE C19, FKC-876

Approved

Cabaret Biotech

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Primary mediastinal B cell lymphoma

Autologous CAR19 T lymphocytes(Institute of Hematology and Blood Transfusion, Czech Republic)

Institute of Hematology and Blood Transfusion, Czech Republic

Loncastuximab tesirine

ADCT-402

Approved

Adc Therapeutics

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Follicular, Lymphoma, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Burkitt Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell

Inebilizumab

16C4-aFuc, MEDI-551, MT-0551, VIB-0551

Approved

Duke University

Rejection of renal transplantation, Myasthenia Gravis, Lymphoma, B-Cell, Hematologic Neoplasms, Immunoglobulin G4-Related Disease, Scleroderma, Systemic, Lymphoma, Large B-Cell, Diffuse, Multiple Sclerosis, Neuromyelitis Optica, Leukemia, Lymphocytic, Chronic, B-Cell

Relmacabtagene autoleucel

JWCAR-029

Approved

Suzhou Yaomingjunuo Biotechnology Co Ltd

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Mantle-Cell, Lymphoma, Non-Hodgkin

Tisagenlecleucel

LG-740, CART-19, CTL-019, CART-019

Approved

University Of Pennsylvania, Novartis Pharma Ag

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Plasmablastic Lymphoma, Leukemia, B-Cell, Lymphoma, Non-Hodgkin

Lisocabtagene maraleucel (Celgene/Juno Therapeutics)

Liso-Cel, JCAR-017, JWCAR-029

Approved

Juno Therapeutics, Fred Hutchinson Cancer Research Center, Memorial Sloan Kettering Cancer Center, Seattle Children'S Research Institute

Lymphoma, B-Cell, Immunoproliferative Disorders, Lymphatic Diseases, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoproliferative Disorders, Lymphoma, Non-Hodgkin, Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell

Blinatumomab

MEDI-538, MT-103, BiTE-MT-103, bscCD19xCD3, AMG-103

Approved

Amgen Inc

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin, Burkitt Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell

References


Title

Authors

Source

Regulatory role of CD19 molecules in B-cell activation and differentiation

de Rie M.A., Schumacher T.N., van Schijndel G.M., van Lier R.A., Miedema F.,

Cell. Immunol. 118:368-381(1989)

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19

Matsumoto A.K., Kopicky-Burd J., Carter R.H., Tuveson D.A., Tedder T.F., Fearon D.T.,

J. Exp. Med. 173:55-64(1991)

CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail

Stamenkovic I., Seed B.,

J. Exp. Med. 168:1205-1210(1988)

Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily

Tedder T.F., Isaacs C.M.,

J. Immunol. 143:712-717(1989)

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M.,

Mol. Cell. Biol. 12:2662-2672(1992)

Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes

Zhou L.J., Ord D.C., Omori S.A., Tedder T.F.,

Immunogenetics 35:102-111(1992)

Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese

Kuroki K., Tsuchiya N., Tsao B.P., Grossman J.M., Fukazawa T., Hagiwara K., Kano H., Takazoe M., Iwata T., Hashimoto H., Tokunaga K.,

Genes Immun. 3:S21-S30(2002)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The sequence and analysis of duplication-rich human chromosome 16

Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Pennacchio L.A.,

Nature 432:988-994(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)