CD2

Synonyms

T-Cell Surface Antigen T11/Leu-5, Lymphocyte-Function Antigen-2, Erythrocyte Receptor, CD2, CD2 Antigens, LFA-3 Receptor, T11, T-Cell Surface Antigen CD2, LFA-2, Rosette Receptor, CD2 Molecule, CD2 Antigen, SRBC, CD2 Antigen (P50), Sheep Red Blood Cell Receptor

Description

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2,LFA-3 receptor, erythrocyte receptor and rosette receptor.CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

KO Status

Immunization

Drug Information

Launched drug: 1
Drug in clinical trials: 1
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

TCD-601

TCD-601

Phase 2 Clinical

Itb-Med

Rejection of renal transplantation

BTI 322

BTI-322

Discontinued

University Of Leuven

Rejection of renal transplantation, Rejection of liver transplantation, Autoimmune Diseases, Graft vs Host Disease

Siplizumab

MEDI-507

Discontinued

Catholic University Of Louvain

Rejection of renal transplantation, Neoplasms, Kidney Diseases, Graft vs Host Disease, Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic, Lymphoma, T-Cell

Alefacept

ASP-0485, LFA-3-TIP, LFA-3(92)IgG, BG-9273, BG-9712

Withdrawn

Astellas Pharma Inc

Psoriasis

References


Title

Authors

Source

Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen

Sewell W.A., Brown M.H., Dunne J., Owen M.J., Crumpton M.J.,

Proc. Natl. Acad. Sci. U.S.A. 83:8718-8722(1986)

Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes

Sayre P.H., Chang H.-C., Hussey R.E., Brown N.R., Richardson N.E., Spagnoli G., Clayton L.K., Reinherz E.L.,

Proc. Natl. Acad. Sci. U.S.A. 84:2941-2945(1987)

The structure of the human CD2 gene and its expression in transgenic mice

Lang G., Wotton D., Owen M.J., Sewell W.A., Brown M.H., Mason D.Y., Crumpton M.J., Kioussis D.,

EMBO J. 7:1675-1682(1988)

The DNA sequence and biological annotation of human chromosome 1

Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Bentley D.R.,

Nature 441:315-321(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)

Peterson A., Seed B.,

Nature 329:842-846(1987)

Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59

Hahn W.C., Menu E., Bothwell A.L.M., Sims P.J., Bierer B.E.,

Science 256:1805-1807(1992)

A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion

Li J., Nishizawa K., An W., Hussey R.E., Lialios F.E., Salgia R., Sunder-Plassmann R., Reinherz E.L.,

EMBO J. 17:7320-7336(1998)

Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution

Bodian D.L., Jones E.Y., Harlos K., Stuart D.I., Davis S.J.,

Structure 2:755-766(1994)

Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2

Withka J.M., Wyss D.F., Wagner G., Arulanandam A.R.N., Reinherz E.L., Recny M.A.,

Structure 1:69-81(1993)