CD20

Synonyms

B-lymphocyte surface antigen B1, MS4A1, B-lymphocyte antigen CD20, Membrane Spanning 4-Domains A1, Leukocyte Surface Antigen Leu-16, CD20 Antigen, CD20, Bp35, Membrane-Spanning 4-Domains Subfamily A Member 1, CD20 Receptor, LEU-16, CVID5, MS4A2, B1, S7, Antigens, CD20, Membrane-Spanning 4-Domains, Subfamily A, Member 1, B-Lymphocyte Cell-Surface Antigen B1,

Description

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes . Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR .

KO Status

F1 (+/-)

Drug Information

Launched drugs: 72
Drugs in clinical trials: 22
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Rituximab biosimilar (Mabion)

MabionCD-20

NDA/BLA

Mabion

Arthritis, Rheumatoid, Lymphoma, Large B-Cell, Diffuse

Rituximab biosimilar (Probiomed)

PBO-326

Approved

Probiomed

Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin

Recombinant chimeric anti-CD20 monoclonal antibody (Sinocelltech)

SCT-400

NDA/BLA

Shenzhou Cell Engineering Co Ltd

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Non-Hodgkin

Rituximab biosimilar (AryoGen Biopharma)

Approved

Aryogen Biopharma

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin

Rituximab-arrx (Amgen)

ABP-798, APB-798

Approved

Amgen Inc

Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Rituximab biosimilar (Siam Bioscience)

NDA/BLA

Siam Bioscience

Lymphoma, B-Cell

Rituximab biosimilar (Biosidus)

Approved

Biosidus

Hematologic Neoplasms

Rituximab biosimilar (Hetero Drugs)

Approved

Hetero Drugs

Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Recombinant anti-CD20 monoclonal antibody (Geneky Biotech)

IND

Xinlitai (Chengdu) Biological Technology Co Ltd

Arthritis, Rheumatoid, Lymphoma

Rituximab biosimilar (Nichi-Iko Pharmaceutical/Aprogen)

AP-056

NDA/BLA

Nichi-Iko Pharmaceutical, Aprogen

Leukemia, Autoimmune Diseases, Rejection of organ transplantation, Lymphoma, Non-Hodgkin

Recombinant anti-CD20 humanized monoclonal antibody (Shanghai Crosslink Pharmaceutical)

IND

Shanghai Crosslink Pharmaceutical R & D Co Ltd

Rituximab biosimilar (Reliance Life Sciences)

R-TPR-017

Approved

Reliance Life Sciences

Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin

Rituximab biosimilar (Center of Molecular Immunology)

Approved

Center Of Molecular Immunology

Lymphoma, Non-Hodgkin

Ocrelizumab

R-1594, RG-1594, PRO-70769, RO-4964913, rhuMab 2H7

Approved

Genentech Inc

Multiple Sclerosis, Relapsing-Remitting, Arthritis, Rheumatoid, Multiple Sclerosis, Multiple Sclerosis, Chronic Progressive, Lupus Erythematosus, Systemic, Lymphoma, Non-Hodgkin

Rituximab biosimilar (Celltrion)

CT-P10

Approved

Celltrion

Microscopic Polyangiitis, Arthritis, Rheumatoid, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

CD20-directed CAR-T cell therapy (Tongji Hospital)

C-CAR066

Tongji Hospital

Rituximab biosimilar (Pfizer)

PF-5280586, PF-05280586

Approved

Pfizer Pharmaceuticals Ltd (China)

Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Pemphigus

rituximab biosimilar (Zenotech)

Approved

Zenotech Laboratories

Lymphoma, Non-Hodgkin

Rituximab biosimilar (Biocad)

BCD-020

Approved

Biocad

Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Rituximab biosimilar (mAbxience)

RTXM-83, mAbx-02

Approved

Mabxience

Lymphoma, Large B-Cell, Diffuse