CD20

Synonyms

B-lymphocyte surface antigen B1, MS4A1, B-lymphocyte antigen CD20, Membrane Spanning 4-Domains A1, Leukocyte Surface Antigen Leu-16, CD20 Antigen, CD20, Bp35, Membrane-Spanning 4-Domains Subfamily A Member 1, CD20 Receptor, LEU-16, CVID5, MS4A2, B1, S7, Antigens, CD20, Membrane-Spanning 4-Domains, Subfamily A, Member 1, B-Lymphocyte Cell-Surface Antigen B1

Description

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes . Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR .

KO Status

RenMab: F2 (-/-)

Drug Information

Launched drugs: 22
Drugs in clinical trials: 72
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Rituximab biosimilar (Center of Molecular Immunology)

Approved

Center Of Molecular Immunology

Lymphoma, Non-Hodgkin

Ocrelizumab

R-1594, RG-1594, PRO-70769, RO-4964913, rhuMab 2H7

Approved

Genentech Inc

Multiple Sclerosis, Relapsing-Remitting, Arthritis, Rheumatoid, Multiple Sclerosis, Multiple Sclerosis, Chronic Progressive, Lupus Erythematosus, Systemic, Lymphoma, Non-Hodgkin

Rituximab biosimilar (Shanghai Henlius Biotech)

HLX-01

Approved

Shanghai Henlius Biotech Co Ltd

Lymphoma, B-Cell, Arthritis, Rheumatoid, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Non-Hodgkin

Rituximab biosimilar (Hetero Drugs)

Approved

Hetero Drugs

Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

CD19/CD20 CAR-T Cell Therapy (PersonGen)

Rituximab biosimilar (Reliance Life Sciences)

R-TPR-017

Approved

Reliance Life Sciences

Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin

Rituximab biosimilar (AryoGen Biopharma)

Approved

Aryogen Biopharma

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin

Hyaluronidase/Rituximab

Approved

Genentech Inc

Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Leukemia, Lymphocytic, Chronic, B-Cell

Rituximab biosimilar (Intas Biopharmaceuticals)

Approved

Intas Biopharmaceuticals

Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Rituximab biosimilar (Innovent Biologics)

IBI-301

Approved

Innovent Biologics(Suzhou) Co Ltd

Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

References

Title

Authors

Source

Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes

Tedder T.F., Streuli M., Schlossman S.F., Saito H.,

Proc. Natl. Acad. Sci. U.S.A. 85:208-212(1988)

Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains

Einfeld D.A., Brown J.P., Valentine M.A., Clark E.A., Ledbetter J.A.,

EMBO J. 7:711-717(1988)

Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1)

Tedder T.F., Klejman G., Schlossman S.F., Saito H.,

J. Immunol. 142:2560-2568(1989)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies

Niederfellner G., Lammens A., Mundigl O., Georges G.J., Schaefer W., Schwaiger M., Franke A., Wiechmann K., Jenewein S., Slootstra J.W., Timmerman P., Brannstrom A., Lindstrom F., Mossner E., Umana P., Hopfner K.P., Klein C.,

Blood 118:358-367(2011)

Human chromosome 11 DNA sequence and analysis including novel gene identification

Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,

Nature 440:497-500(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

The B cell surface molecule B1 is functionally linked with B cell activation and differentiation

Tedder T.F., Boyd A.W., Freedman A.S., Nadler L.M., Schlossman S.F.,

J. Immunol. 135:973-979(1985)

Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes. Regulation by protein kinase C

Valentine M.A., Meier K.E., Rossie S., Clark E.A.,

J. Biol. Chem. 264:11282-11287(1989)

Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes

Bubien J.K., Zhou L.J., Bell P.D., Frizzell R.A., Tedder T.F.,

J. Cell Biol. 121:1121-1132(1993)

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