CD20

Synonyms

B-lymphocyte surface antigen B1, MS4A1, B-lymphocyte antigen CD20, Membrane Spanning 4-Domains A1, Leukocyte Surface Antigen Leu-16, CD20 Antigen, CD20, Bp35, Membrane-Spanning 4-Domains Subfamily A Member 1, CD20 Receptor, LEU-16, CVID5, MS4A2, B1, S7, Antigens, CD20, Membrane-Spanning 4-Domains, Subfamily A, Member 1, B-Lymphocyte Cell-Surface Antigen B1

Description

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes . Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR .

KO Status

F2 (-/-)

Drug Information

Launched drugs: 22
Drugs in clinical trials: 72
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Rituximab biosimilar (Sandoz)

GP-2013

Approved

Sandoz

Granulomatosis with Polyangiitis, Lymphoma, B-Cell, Microscopic Polyangiitis, Arthritis, Rheumatoid, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Pemphigus

Rituximab biosimilar (mAbxience)

RTXM-83, mAbx-02

Approved

Mabxience

Lymphoma, Large B-Cell, Diffuse

Rituximab biosimilar (Hetero Drugs)

Approved

Hetero Drugs

Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Rituximab biosimilar (Reliance Life Sciences)

R-TPR-017

Approved

Reliance Life Sciences

Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin

Rituximab biosimilar (AryoGen Biopharma)

Approved

Aryogen Biopharma

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin

Rituximab biosimilar (Center of Molecular Immunology)

Approved

Center Of Molecular Immunology

Lymphoma, Non-Hodgkin

Rituximab biosimilar (Probiomed)

PBO-326

Approved

Probiomed

Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin

CD20-directed CAR-T cell therapy (Tongji Hospital)

C-CAR066

Tongji Hospital

Rituximab biosimilar (Celltrion)

CT-P10

Approved

Celltrion

Microscopic Polyangiitis, Arthritis, Rheumatoid, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Rituximab biosimilar (Pfizer)

PF-5280586, PF-05280586

Approved

Pfizer Pharmaceuticals Ltd (China)

Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Arthritis, Rheumatoid, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Pemphigus

References

Title

Authors

Source

Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes

Tedder T.F., Streuli M., Schlossman S.F., Saito H.,

Proc. Natl. Acad. Sci. U.S.A. 85:208-212(1988)

Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains

Einfeld D.A., Brown J.P., Valentine M.A., Clark E.A., Ledbetter J.A.,

EMBO J. 7:711-717(1988)

Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1)

Tedder T.F., Klejman G., Schlossman S.F., Saito H.,

J. Immunol. 142:2560-2568(1989)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies

Niederfellner G., Lammens A., Mundigl O., Georges G.J., Schaefer W., Schwaiger M., Franke A., Wiechmann K., Jenewein S., Slootstra J.W., Timmerman P., Brannstrom A., Lindstrom F., Mossner E., Umana P., Hopfner K.P., Klein C.,

Blood 118:358-367(2011)

Human chromosome 11 DNA sequence and analysis including novel gene identification

Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,

Nature 440:497-500(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

The B cell surface molecule B1 is functionally linked with B cell activation and differentiation

Tedder T.F., Boyd A.W., Freedman A.S., Nadler L.M., Schlossman S.F.,

J. Immunol. 135:973-979(1985)

Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes. Regulation by protein kinase C

Valentine M.A., Meier K.E., Rossie S., Clark E.A.,

J. Biol. Chem. 264:11282-11287(1989)

Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes

Bubien J.K., Zhou L.J., Bell P.D., Frizzell R.A., Tedder T.F.,

J. Cell Biol. 121:1121-1132(1993)

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