CD38
Synonyms
EC:3.2.2.6, EC:2.4.99.20, 2-Phospho-Cyclic-ADP-Ribose Transferase, Cyclic ADP-Ribose Hydrolase 1, 2-Phospho-ADP-Ribosyl Cyclase, NAD(+) Nucleosidase, CD38 Antigen (P45), 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase, Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase, ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1, Cluster Of Differentiation 38, CD38 Antigen, EC 2.4.99.20, EC 3.2.2.6, ADPRC1, T10, 2'-phospho-ADP-ribosyl cyclase, ADPRC 1, cADPr hydrolase 1, ADP-ribosyl cyclase 1, 2'-phospho-cyclic-ADP-ribose transferase, CD38, CD38 Molecule, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
Description
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
KO Status
RenMab: Immunization
RenLite: F1 (+/-)
Drug Information
Launched drugs: 3
Drugs in clinical trials: 18
Latest Research Phase: Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Daratumumab
JNJ-54767414
Approved
Janssen Global Services Llc
Lymphoma, B-Cell, Smoldering Multiple Myeloma, Hodgkin Disease, Lymphoma, Large B-Cell, Diffuse, Myelodysplastic Syndromes, Multiple Myeloma, Lymphoma, Extranodal NK-T-Cell, Lymphoma, Follicular, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Mantle-Cell, Colorectal Neoplasms, Amyloidosis, Lymphoma, Non-Hodgkin, Lymphoma, Large intestine neoplasm
Isatuximab
SAR-650984
Approved
Immunogen Inc
Bone Marrow Neoplasms, Carcinoma, Transitional Cell, Smoldering Multiple Myeloma, Urinary Bladder Neoplasms, Multiple Myeloma, Anemia, Hemolytic, Autoimmune, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Colorectal Neoplasms, Leukemia, Myeloid, Acute
Daratumumab/Hyaluronidase-fihj
Approved
Janssen Global Services Llc
Multiple Myeloma, Amyloidosis
Felzartamab
TJ-202, MOR-202, MOR-03087
Phase 3 Clinical
Morphosys Ag
Multiple Myeloma, Glomerulonephritis, Membranous, Glomerulonephritis
TAK-573
TAK-573, TEV-48573
Phase 2 Clinical
Takeda Pharmaceutical Co Ltd
Multiple Myeloma, Melanoma
TAK-079
TAK-079
Phase 2 Clinical
Takeda
Purpura, Thrombocytopenic, Idiopathic, Myasthenia Gravis, Autoimmune Diseases, Multiple Myeloma, Lupus Erythematosus, Systemic
89Zr-DFO-daratumumab
Phase 2 Clinical
Memorial Sloan Kettering Cancer Center
4SCAR-T cell therapy (Shenzhen Geno-Immune Medical Institute)
4SCAR-T
Phase 2 Clinical
Shenzhen Geno-Immune Medical Institute
Neoplasms
CART-38
CART-38
Phase 2 Clinical
The First Affiliated Hospital Of Soochow University
Leukemia, Myeloid, Acute
Anti CD38 chimeric antigen receptor T-cell therapy (Sorrento Therapeutics)
Phase 1 Clinical
Celularity, Sorrento Therapeutics
Multiple Myeloma
References
Title
Authors
Source
Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation
Jackson D.G., Bell J.I.,
J. Immunol. 144:2811-2815(1990)
Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing
Nata K., Takamura T., Karasawa T., Kumagai T., Hashioka W., Tohgo A., Yonekura H., Takasawa S., Nakamura S., Okamoto H.,
Gene 186:285-292(1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38
States D.J., Walseth T.F., Lee H.C.,
Trends Biochem. Sci. 17:495-495(1992)
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP
Takasawa S., Tohgo A., Noguchi N., Koguma T., Nata K., Sugimoto T., Yonekura H., Okamoto H.,
J. Biol. Chem. 268:26052-26054(1993)
Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38
Tohgo A., Takasawa S., Noguchi N., Koguma T., Nata K., Sugimoto T., Furuya Y., Yonekura H., Okamoto H.,
J. Biol. Chem. 269:28555-28557(1994)
An unappreciated role for RNA surveillance
Hillman R.T., Green R.E., Brenner S.E.,
Genome Biol. 5:R8.1-R8.16(2004)
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases
Moreschi I., Bruzzone S., Melone L., De Flora A., Zocchi E.,
Biochem. Biophys. Res. Commun. 345:573-580(2006)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.,
J. Proteome Res. 8:651-661(2009)
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.,
Nat. Biotechnol. 27:378-386(2009)