CD38

Synonyms

EC:3.2.2.6, 2-Phospho-Cyclic-ADP-Ribose Transferase, Cyclic ADP-Ribose Hydrolase 1, 2-Phospho-ADP-Ribosyl Cyclase, NAD(+) Nucleosidase, CD38 Antigen (P45), 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase, Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase, ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1, Cluster Of Differentiation 38, CD38 Antigen, EC 2.4.99.20, EC 3.2.2.6, ADPRC1, T10, 2'-phospho-ADP-ribosyl cyclase, ADPRC 1, cADPr hydrolase 1, ADP-ribosyl cyclase 1, 2'-phospho-cyclic-ADP-ribose transferase, CD38, CD38 Molecule, EC:2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

Description

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. CD38 also functions in cell adhesion, signal transduction and calcium signaling.

KO Status

F2 (-/-)

Drug Information

Launched drugs: 3
Drugs in clinical trials: 14
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

89Zr-DFO-daratumumab

Memorial Sloan Kettering Cancer Center

LQ-032

LQ-032, LQ032

Daratumumab

JNJ-54767414

Approved

Janssen Global Services Llc

Lymphoma, B-Cell, Hodgkin Disease, Lymphoma, Large B-Cell, Diffuse, Myelodysplastic Syndromes, Smoldering Multiple Myeloma, Multiple Myeloma, Lymphoma, Extranodal NK-T-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Follicular, Lymphoma, Mantle-Cell, Colorectal Neoplasms, Amyloidosis, Lymphoma, Non-Hodgkin, Lymphoma, Large intestine neoplasm

Daratumumab/Hyaluronidase-fihj

Approved

Janssen Global Services Llc

Multiple Myeloma, Amyloidosis

Isatuximab

SAR-650984

Approved

Immunogen Inc

Bone Marrow Neoplasms, Carcinoma, Transitional Cell, Smoldering Multiple Myeloma, Multiple Myeloma, Urinary Bladder Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Anemia, Hemolytic, Autoimmune, Colorectal Neoplasms, Leukemia, Myeloid, Acute

MOR-202

TJ-202, MOR-202, MOR-03087

Phase 3 Clinical

Morphosys Ag

Multiple Myeloma, Glomerulonephritis, Membranous, Glomerulonephritis

TAK-079

TAK-079

Phase 2 Clinical

Takeda

Purpura, Thrombocytopenic, Idiopathic, Myasthenia Gravis, Autoimmune Diseases, Multiple Myeloma, Lupus Erythematosus, Systemic

4SCAR-T cell therapy (Shenzhen Geno-Immune Medical Institute)

4SCAR-T

Phase 2 Clinical

Shenzhen Geno-Immune Medical Institute

Neoplasms

CART-38

CART-38

Phase 2 Clinical

The First Affiliated Hospital Of Soochow University

Leukemia, Myeloid, Acute

TAK-573

TAK-573, TEV-48573

Phase 2 Clinical

Takeda Pharmaceutical Co Ltd

Multiple Myeloma, Melanoma

References


Title

Authors

Source

Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation

Jackson D.G., Bell J.I.,

J. Immunol. 144:2811-2815(1990)

Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing

Nata K., Takamura T., Karasawa T., Kumagai T., Hashioka W., Tohgo A., Yonekura H., Takasawa S., Nakamura S., Okamoto H.,

Gene 186:285-292(1997)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38

States D.J., Walseth T.F., Lee H.C.,

Trends Biochem. Sci. 17:495-495(1992)

Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP

Takasawa S., Tohgo A., Noguchi N., Koguma T., Nata K., Sugimoto T., Yonekura H., Okamoto H.,

J. Biol. Chem. 268:26052-26054(1993)

Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38

Tohgo A., Takasawa S., Noguchi N., Koguma T., Nata K., Sugimoto T., Furuya Y., Yonekura H., Okamoto H.,

J. Biol. Chem. 269:28555-28557(1994)

An unappreciated role for RNA surveillance

Hillman R.T., Green R.E., Brenner S.E.,

Genome Biol. 5:R8.1-R8.16(2004)

NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases

Moreschi I., Bruzzone S., Melone L., De Flora A., Zocchi E.,

Biochem. Biophys. Res. Commun. 345:573-580(2006)

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry

Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.,

J. Proteome Res. 8:651-661(2009)

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.,

Nat. Biotechnol. 27:378-386(2009)