CFB

Synonyms

C3 Proaccelerator, C3 Proactivator, EC 3.4.21.47, ARMD14, AHUS4, FBI12, H2-Bf, CFAB, CFBD, FB, Complement Factor B, EC 3.4.21, Properdin factor B, BF, Glycine-rich beta glycoprotein, CFB, B-Factor, Properdin, C3/C5 Convertase, PBF2, BFD, GBG, Glycine-Rich Beta-Glycoprotein, EC:3.4.21.47,

Description

Complement factor B (CFB) which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

KO Status

F0

Drug Information

Launched drugs: 2
Drugs in clinical trials: 0
Latest Research Phase:Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Iptacopan

LNP-023

Phase 3 Clinical

Novartis Pharma Ag

Glomerulonephritis, IGA, Hemoglobinuria, Paroxysmal, Nephrosis, Glomerulonephritis, Membranous, Glomerulonephritis

IONIS-FB-LRx

IONIS-GSK4-LRx, ISIS-696844, ISIS-GSK4Rx, IONIS-FB-LRx, ISIS-GSK4-LRx

Phase 2 Clinical

Ionis

Glomerulonephritis, IGA, Geographic Atrophy, Macular Degeneration

FC-2.15

FC-2.15

Discontinued

University Of Buenos Aires

Neoplasms