FFAR1
Synonyms
FFAR1, Free Fatty Acid Receptor 1, G-Protein Coupled Receptor 40, GPR40, G Protein-Coupled Receptor 40, GPCR40, FFA1R,Description
Free fatty acid receptor 1 (FFA1), also known as GPR40, is a class A G-protein coupled receptor that in humans is encoded by the FFAR1 gene.G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.
KO Status
F0
Drug Information
Launched drugs: 5
Drugs in clinical trials: 0
Latest Research Phase:Phase 3 Clinical
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Setogepram
PBI-4050
Phase 3 Clinical
Prometic Life Sciences
Cystic Fibrosis, Diabetes Mellitus, Type 2, Idiopathic Pulmonary Fibrosis, Metabolic Syndrome, Alstrom Syndrome, Diabetes Mellitus
HOB-047
HD-6277, HOB-047, GPR-6277, HDNO-1605
Phase 1 Clinical
Hyundai Pharmaceutical
Diabetes Mellitus, Type 2
CPL-207-280
CPL-207280, CPL-207-280
Phase 1 Clinical
Celon Pharma
Diabetes Mellitus, Type 2
PBI-4547
PBI-4547
Phase 1 Clinical
Prometic Life Sciences
Non-alcoholic Fatty Liver Disease, Liver Cirrhosis, Obesity, Diabetes Mellitus
Fuglifam
Phase 1 Clinical
Jiangsu Hengrui Medicine Co Ltd
Diabetes Mellitus, Type 2
AMG-837 (free acid)
AMG-837 (free acid)
Pending
Amgen Inc
Diabetes Mellitus, Type 2
P-11187
P-11187
Pending
Piramal Phytocare
Diabetes Mellitus, Type 2, Overweight
LY-2922470
LY-2922470
Pending
Eli Lilly And Company
Diabetes Mellitus, Type 2
MK-8666
MK-8666
Pending
Merck Sharp & Dohme Corp
Diabetes Mellitus, Type 2
LY-2922083
LY-2922083
Pending
Eli Lilly And Company
Diabetes Mellitus, Type 2
Fasiglifam
TAK-875
Discontinued
Takeda Pharmaceutical Co Ltd
Diabetes Mellitus, Type 2, Cardiovascular Diseases, Renal Insufficiency, Chronic, Diabetes Mellitus
JTT-851
JTT-851
Discontinued
Japan Tobacco
Diabetes Mellitus, Type 2
ASP-4178
ASP-4178, AS-2034178
Discontinued
Astellas Pharma Inc
Diabetes Mellitus, Type 2
LY-2881835
LY-2881835
Discontinued
Eli Lilly And Company
Diabetes Mellitus, Type 2