FGF2

Synonyms

FGF-2, Heparin-binding growth factor 2, Basic fibroblast growth factor, FGFB, bFGF, HBGF-2, FGF2, Fibroblast Growth Factor 2 (Basic), Basic Fibroblast Growth Factor BFGF, Prostatropin, Fibroblast Growth Factor 2

Description

Fibroblast growth factor 2 is a growth factor and signaling protein encoded by the FGF2 gene.It is synthesized primarily as a 155 amino acid polypeptide, resulting in an 18 kDa protein. However, there are four alternate start codons which provide N-terminal extensions of 41, 46, 55, or 133 amino acids, resulting in proteins of 22 kDa (196 aa total), 22.5 kDa (201 aa total), 24 kDa (210 aa total) and 34 kDa (288 aa total), respectively.Generally, the 155 aa/18 kDa low molecular weight (LMW) form is considered cytoplasmic and can be secreted from the cell, whereas the high molecular weight (HMW) forms are directed to the cell's nucleus.

KO Status

RenMab: F0

Drug Information

Launched drugs: 2
Drugs in clinical trials: 3
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Pentosan Polysulfate Sodium

PPS, PZ-68, SP-54, AK-150

Approved

Ivax, Teva

Pain, Cystitis, Interstitial, Prostatitis, Osteoarthritis, Knee

Thalidomide

NSC-66847, NSC-527179, K-17, VP-02

Approved

Celgene Corp

HIV Infections, Spondylitis, Ankylosing, Myelodysplastic Syndromes, Idiopathic Pulmonary Fibrosis, Multiple Myeloma, HIV Wasting Syndrome, Erythema Nodosum, Leprosy, Lepromatous, Carcinoma, Hepatocellular

Muparfostat sodium

PI-88

Phase 3 Clinical

Australian National University

Liver Neoplasms, Solid tumours, Prostatic Neoplasms, Lung Neoplasms, Carcinoma, Hepatocellular, Melanoma, Carcinoma, Non-Small-Cell Lung

RBM-007

RBM-007, ID3 (21), APT-F2

Phase 2 Clinical

Ribomic

Macular Degeneration

Fibroblast growth factor 2 gene therapy (ID Pharma)

SEV-10101, DVC-10101

Phase 2 Clinical

Dnavec

Ischemia, Peripheral Arterial Disease

Basic fibroblast growth factor (Kyoto University)

FGF-19X, hFGF-21

Pending

Kyoto University

Peripheral Arterial Disease

Palifermin biosimilar (Genemen Biotech)

Pending

Genemen Biotech

Stomatitis

BMS-584622

BMS-584622

Discontinued

Bristol-Myers Squibb Company

Vascular Diseases

Squalamine

OHR-102, MSI-1256F

Discontinued

Genaera

Macular Edema, Wet Macular Degeneration, Macular Degeneration, Retinal Vein Occlusion

Fibroblast growth factor pellets (Montefiore)

Discontinued

Montefiore Medical Center

Coronary Artery Disease

References


Title

Authors

Source

Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells

Abraham J.A., Whang J.L., Tumolo A., Mergia A., Fiddes J.C.,

Cold Spring Harb. Symp. Quant. Biol. 51:657-668(1986)

Human basic fibroblast growth factor: nucleotide sequence and genomic organization

Abraham J.A., Whang J.L., Tumolo A., Mergia A., Friedman J., Gospodarowicz D., Fiddes J.C.,

EMBO J. 5:2523-2528(1986)

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons

Prats H., Kaghad M., Prats A.C., Klagsbrun M., Lelias J.M., Liauzun P., Chalon P., Tauber J.P., Amalric F., Smith J.A., Caput D.,

Proc. Natl. Acad. Sci. U.S.A. 86:1836-1840(1989)

Three-dimensional structure of human basic fibroblast growth factor

Eriksson A.E., Cousens L.S., Weaver L.H., Matthews B.W.,

Proc. Natl. Acad. Sci. U.S.A. 88:3441-3445(1991)

Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta

Zhang J., Cousens L.S., Barr P.J., Sprang S.R.,

Proc. Natl. Acad. Sci. U.S.A. 88:3446-3450(1991)

Three-dimensional structures of acidic and basic fibroblast growth factors

Zhu X., Komiya H., Chirino A., Faham S., Fox G.M., Arakawa T., Hsu B.T., Rees D.C.,

Science 251:90-93(1991)

Receptor specificity of the fibroblast growth factor family

Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M.,

J. Biol. Chem. 271:15292-15297(1996)

High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan

Goretzki L., Burg M.A., Grako K.A., Stallcup W.B.,

J. Biol. Chem. 274:16831-16837(1999)

Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein

Tassi E., Al-Attar A., Aigner A., Swift M.R., McDonnell K., Karavanov A., Wellstein A.,

J. Biol. Chem. 276:40247-40253(2001)

Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor

Skjerpen C.S., Wesche J., Olsnes S.,

J. Biol. Chem. 277:23864-23871(2002)