GHR

Synonyms

GHR, Somatotropin receptor, Serum-binding protein, GH-binding protein, GHBP, Growth Hormone Receptor, Growth Hormone Binding Protein, GH Receptor, Serum Binding Protein, GHIP, Receptors, Somatotropin

Description

GHR is a receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway.The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

KO Status

F0

Drug Information

Launched drugs: 25
Drugs in clinical trials: 17
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Somatropin (rDNA origin, Genentech)

SMP-140, rhGH (Genentech)

Approved

Genentech Inc

Cystic Fibrosis, Turner Syndrome, Growth Disorders, Dwarfism, Renal Insufficiency, Chronic, Dwarfism, Pituitary, Growth hormone deficiency

Recombinant human growth hormone (Shenzhen Kexing Biotech)

Approved

Shenzhen Kexing Biological Engineering Co Ltd

Growth hormone deficiency

Somatropin biosimilar (Chalver Laboratorios)

Approved

Chalver Laboratorios

Growth hormone deficiency

Recombinant Human Growth Hormone for Injection (Zhongshan Sinobioway Hygene Biomedicine)

Approved

Zhongshan Hygene Biopharm Co Ltd

Growth Disorders, Growth hormone deficiency

Recombinant human growth hormone (BioGeneric Pharma)

Approved

Biogeneric

Growth hormone deficiency

Somatropin biosimilar (Amega Biotech)

Approved

Amega Biotech

Growth hormone deficiency

Recombinant Somatropin (Vetter Pharma)

Approved

Growth hormone deficiency

Somatropin biosimilar (SICOR Biotech UAB)

Approved

Teva Pharmaceutical Industries Ltd

Growth hormone deficiency

Somatropin (Dong-A ST)

DA-3002

Approved

Dong-A St

Idiopathic short stature, Turner Syndrome, Dwarfism

Recombinant human growth hormone (GeneScience Pharmaceuticals)

Approved

Changchun Genescience Pharmaceutical Co Ltd

Idiopathic short stature, Growth Disorders, Burns, Dwarfism, Infant, Premature, Diseases, Growth hormone deficiency

References


Title

Authors

Source

The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: suppression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration

Jorge A.A.L., Souza S.C.A.L., Arnhold I.J.P., Mendonca B.B.,

Clin. Endocrinol. (Oxf.) 60:36-40(2004)

Growth hormone receptor mutations in children with idiopathic short stature

Sanchez J.E., Perera E., Baumbach L., Cleveland W.W.,

J. Clin. Endocrinol. Metab. 83:4079-4083(1998)

Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor

Wojcik J., Berg M.A., Esposito N., Geffner M.E., Sakati N., Reiter E.O., Dower S., Francke U., Postel-Vinay M.-C., Finidori J.,

J. Clin. Endocrinol. Metab. 83:4481-4489(1998)

Characterization of single-nucleotide polymorphisms in coding regions of human genes

Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.,

Nat. Genet. 22:231-238(1999)

Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation

Enberg B., Luthman H., Segnestam K., Ritzen E.M., Sundstroem M., Norstedt G.,

Eur. J. Endocrinol. 143:71-76(2000)

Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred

Takada D., Ezura Y., Ono S., Iino Y., Katayama Y., Xin Y., Wu L.L., Larringa-Shum S., Stephenson S.H., Hunt S.C., Hopkins P.N., Emi M.,

Am. J. Med. Genet. A 121:136-140(2003)

Growth hormone receptor and serum binding protein: purification, cloning and expression

Leung D.W., Spencer S.A., Cachianes G., Hammonds R.G., Collins C., Henzel W.J., Barnard R., Waters M.J., Wood W.I.,

Nature 330:537-543(1987)

Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism

Godowski P.J., Leung D.W., Meacham L.R., Galgani J.P., Hellmiss R., Keret R., Rotwein P.S., Parks J.S., Laron Z., Wood W.I.,

Proc. Natl. Acad. Sci. U.S.A. 86:8083-8087(1989)

Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript

Urbanek M., MacLeod J.N., Cooke N.E., Liebhaber S.A.,

Mol. Endocrinol. 6:279-287(1992)

Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein

Dastot F., Sobrier M.-L., Duquesnoy P., Duriez B., Goossens M., Amselem S.,

Proc. Natl. Acad. Sci. U.S.A. 93:10723-10728(1996)