GIPR

Synonyms

Gastric inhibitory polypeptide receptor, GIPR, Glucose-Dependent Insulinotropic Polypeptide Receptor, GIP-R, PGQTL2

Description

GIPR (Gastric inhibitory polypeptide receptor) is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

KO Status

RenMab: F0

Drug Information

Drugs in clinical trials: 6
Latest Research Phase: Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Tirzepatide

LY-3298176

Phase 3 Clinical

Eli Lilly And Company

Heart Failure, Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Renal Insufficiency, Hypoglycemia, Hepatic Insufficiency, Obesity, Overweight, Kidney Failure, Chronic

HM-15211

HM-15211

Phase 2 Clinical

Hanmi Pharmaceutical Co Ltd

Non-alcoholic Fatty Liver Disease, Obesity

dual GLP-1R/GIPR agonists

CT-868

Phase 1 Clinical

Carmot Therapeutics Inc

Obesity, Diabetes Mellitus

CT-388

CT-388

Phase 1 Clinical

Carmot Therapeutics Inc

Diabetes Mellitus

SCO-094

SCO-094

Phase 1 Clinical

Takeda

Hepatitis, Alcoholic, Diabetes Mellitus, Type 2, Obesity

GLP-1/GIP/glucagon tri-agonist (Lilly)

Phase 1 Clinical

Eli Lilly And Company

Diabetes Mellitus

SAR-441255

SAR-441255

Phase 1 Clinical

Sanofi

Diabetes Mellitus, Type 2, Obesity, Overweight

ZP-6590

ZP-6590, ZP 6590

Preclinical

Zealand Pharma

Obesity

ZP-1-98 (Zealand Pharma)

ZP-1-98, ZP-2435, ZP-DI-70

Pending

Zealand Pharma A/S

Diabetes Mellitus, Type 2, Obesity

ZP-3022 (Zealand Pharma)

ZP-3022

Pending

Zealand Pharma A/S

Diabetes Mellitus, Type 2, Obesity

References


Title

Authors

Source

Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma

Volz A., Goke R., Lankat-Buttgereit B., Fehmann H.C., Bode H.P., Goke B.,

FEBS Lett. 373:23-29(1995)

Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

Gremlich S., Porret A., Hani E.H., Cherif D., Vionnet N., Froguel P., Thorens B.,

Diabetes 44:1202-1208(1995)

Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA

Yamada Y., Hayami T., Nakamura K., Kaisaki P.J., Someya Y., Wang C.Z., Seino S., Seino Y.,

Genomics 29:773-776(1995)

The DNA sequence and biology of human chromosome 19

Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Lucas S.M.,

Nature 428:529-535(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization

Whitaker G.M., Lynn F.C., McIntosh C.H., Accili E.A.,

PLoS ONE 7:E32675-E32675(2012)

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

Parthier C., Kleinschmidt M., Neumann P., Rudolph R., Manhart S., Schlenzig D., Fanghanel J., Rahfeld J.-U., Demuth H.-U., Stubbs M.T.,

Proc. Natl. Acad. Sci. U.S.A. 104:13942-13947(2007)