GLP1R

Synonyms

GLP1R, Glucagon-like peptide 1 receptor, Glucagon Like Peptide 1 Receptor, GLP-1 Receptor, GLP-1-R, Seven Transmembrane Helix Receptor, GLP1 Receptor, GLP-1, GLP-1R, Glucagon-Like Peptide-1 Receptor,

Description

Glucagon-like peptide 1 receptor is a receptor protein found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion.In humans it is synthesised by the gene GLP1R, which is present on chromosome 6.It is a member of the glucagon receptor family of G protein-coupled receptors.GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1,and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1.In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.

KO Status

F1 (+/-)

Drug Information

Launched drugs: 60
Drugs in clinical trials: 12
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Exenatide

Ex-4, AC-2993, LY-2148568, AC-2993-LAR

Approved

Astrazeneca Plc, Eli Lilly And Company

Diabetes Mellitus, Type 2, Renal Insufficiency, Obesity, Diabetes Mellitus

Recombinant GLP-1 receptor agonists

IND

Liraglutide (Jiangsu Chia Tai-Tianqing)

Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Shanghai Institute Of Pharmaceutical Industry, Lianyungang Runzhong Pharmaceutical Co Ltd

BEM-012

BEM-012

Preclinical

Shanghai Benemae Pharmaceutical Corp

Diabetes Mellitus, Type 2

SP-1373

SP-1373, VOD-107

Preclinical

Velocity Pharmaceutical Development

Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2, Obesity

Liraglutide (Eastern Virginia Medical School)

Eastern Virginia Medical School

ZP-GG-72

ZP-GG-72

Preclinical

C.H. Boehringer Sohn Ag & Co. Kg, Zealand Pharma

Obesity, Diabetes Mellitus

Albiglutide

PGC-GLP-1, GSK-716155

Approved

Glaxosmithkline Plc

Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Heart Failure

PEG-Loxenatide

PEX-168

Approved

Hansoh Pharma

Diabetes Mellitus, Type 2

Beinaglutide

Approved

Second Military Medical University

Diabetes Mellitus, Type 2, Overweight

BEM-041

BEM-041

Preclinical

Shanghai Benemae Pharmaceutical Corp

Diabetes Mellitus, Type 2

Semaglutide/Insulin 287

NNC0148-0287sema

Approved

Novo Nordisk A/S

Diabetes Mellitus, Type 2

Semaglutide

NN-9535, NNC-0113-0217, NN-9931, NN-9536, 9931

Approved

Novo Nordisk A/S

Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Kidney Diseases, Liver Diseases, Obesity, Renal Insufficiency, Chronic, Overweight, Diabetes Mellitus

Insulin glargine/Lixisenatide

HOE-901/AVE-0010

Approved

Sanofi

Diabetes Mellitus, Type 2

Dulaglutide

GLP-1-Fc, LY-2189265

Approved

Eli Lilly And Company

Diabetes Mellitus, Type 2, Cardiovascular Diseases

Dulaglutide Biosimilar (Luye Pharma)

LY-05008

Preclinical

Luye Pharma Group Ltd

Diabetes Mellitus, Type 2

Liraglutide

NN-2211, NN-8022, NN-9211, NNC-901170, NNC-90-1170

Approved

Novo Nordisk A/S

Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Obesity, Diabetes Mellitus, Overweight

Insulin degludec/Liraglutide

NN-9068

Approved

Novo Nordisk A/S

Diabetes Mellitus, Type 2, Diabetes Mellitus

Semaglutide oral (Novo Nordisk)

NN-9924, OG-217SC, GLP-1-SNAC, NNC0113-0217

Approved

Novo Nordisk A/S

Diabetes Mellitus, Type 2, Diabetes Mellitus

Lixisenatide

ZP-10, AVE0100, AVE-0010, AQVE-10010

Approved

Zealand Pharma, Sanofi

Diabetes Mellitus, Type 2, Acute Coronary Syndrome, Diabetes Mellitus