IAPP

Synonyms

DAP, Amylin, Insulinoma amyloid peptide, IAPP, Diabetes-Associated Peptide, Islet Amyloid Polypeptide (Diabetes-Associated Peptide, Amylin), IAP, Islet Amyloid Polypeptide, Islet Amyloid Polypeptide (Diabetes-Associated Peptide; Amylin)

Description

Islet amyloid polypeptide (IAPP), the main component of islet amyloid in type 2 diabetes and islet transplants, is now recognized as a contributor to beta cell dysfunction. It selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

KO Status

F0

Drug Information

Drugs in clinical trials: 3
Latest Research Phase: Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Allogeneic human islets of Langerhans (University of Illinois)

Phase 3 Clinical

University Of Illinois

Diabetes Mellitus, Type 1

Nirogacestat

PF-3084014, PF-03084014

Phase 3 Clinical

Pfizer Inc

Fibromatosis, Aggressive, Solid tumours, Triple Negative Breast Neoplasms, Pancreatic Neoplasms, Multiple Myeloma, Breast Neoplasms, Alzheimer Disease

Bisnorcymserine

ANVS-301

Phase 1 Clinical

Horizon Therapeutics Plc

Alzheimer Disease

NI-203

NI-203

Preclinical

Neurimmune

Diabetes Mellitus, Type 2

Caprospinol

SP-08, SP-004, SP-008, SP-04m, SP-233, SP-04-Samaritan

Pending

Samaritan

Alzheimer Disease

AC-187

Discontinued

Amylin Pharmaceutical

Diabetes Mellitus

Phenserine tartrate

DWJ301

Discontinued

Qr Pharma

Alzheimer Disease

BI-473494

BI-473494

Discontinued

Zealand Pharma

Obesity, Diabetes Mellitus

ACO-253

AC-253, GG-747, ACO-253, GR-1150747A

Discontinued

Astrazeneca Plc, Bristol-Myers Squibb Company

Diabetes Mellitus, Type 2, Obesity

AC-625

AC-625

Discontinued

Astrazeneca Plc, Bristol-Myers Squibb Company

Hypertension

References


Title

Authors

Source

The complete islet amyloid polypeptide precursor is encoded by two exons

Mosselman S., Hoeppener J.W.M., Lips C.J.M., Jansz H.S.,

FEBS Lett. 247:154-158(1989)

Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history

Nishi M., Sanke T., Seino S., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Bell G.I., Steiner D.F.,

Mol. Endocrinol. 3:1775-1781(1989)

An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing

Sanke T., Bell G.I., Sample C., Rubenstein A.H., Steiner D.F.,

J. Biol. Chem. 263:17243-17246(1988)

The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region

Christmanson L., Rorsman F., Stenman G., Westermark P., Betsholtz C.,

FEBS Lett. 267:160-166(1990)

Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man

van Mansfeld A.D.M., Mosselman S., Hoeppener J.W.M., Zandberg J., van Teeffelen H.A.A.M., Baas P.D., Lips C.J.M., Jansz H.S.,

Biochim. Biophys. Acta 1087:235-240(1990)

Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site

Hoeppener J.W.M., Oosterwijk C., Visser-Vernooy H.J., Lips C.J.M., Jansz H.S.,

Biochem. Biophys. Res. Commun. 189:1569-1577(1992)

Cloning and expression of human islet amyloid polypeptide in cultured cells

Bhattacharya S., Naveena Lavanya Latha J., Kumresan R., Singh S.,

Biochem. Biophys. Res. Commun. 356:622-628(2007)

Islet amyloid polypeptide: identification and chromosomal localization of the human gene

Mosselman S., Hoeppener J.W.M., Zandberg J., van Mansfeld A.D.M., Geurts van Kessel A.H.M., Lips C.J.M., Jansz H.S.,

FEBS Lett. 239:227-232(1988)

Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus

Roberts A.N., Leighton B., Todd J.A., Cockburn D., Schofield P.N., Sutton R., Holt S., Boyd Y., Day A.J., Foot E.A., Willis A.C., Reid K.B.M., Cooper G.J.S.,

Proc. Natl. Acad. Sci. U.S.A. 86:9662-9666(1989)

Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin

Hubbard J.A.M., Martin S.R., Chaplin L.C., Bose C., Kelly S.M., Price N.C.,

Biochem. J. 275:785-788(1991)