IFNB1

Synonyms

Interferon Beta 1, Interferon, Beta 1, Fibroblast, IFNB, IFB, IFF, Interferon-beta, IFN-beta, Fibroblast interferon, IFNB1, Interferon beta

Description

Interferon beta is a protein that in humans is encoded by the IFNB1 gene. It has antiviral, antibacterial and anticancer activities.

KO Status

RenMab: F1 (+/-)

Drug Information

Launched drugs: 3
Drugs in clinical trials: 5
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Interferon beta-1b biosimilar (InSight Biopharmaceuticals)

Approved

Insight Biopharmaceuticals

Multiple Sclerosis

Interferon beta-1a biosimilar (Probiomed S.A)

Approved

Probiomed

Multiple Sclerosis

Peginterferon beta-1a (CinnaGen)

Phase 3 Clinical

Cinnagen

Multiple Sclerosis

VSV-IFNbeta-NIS

Phase 2 Clinical

Vyriad

Solid tumours, Liver Neoplasms, Multiple Myeloma, Colorectal Neoplasms, Carcinoma, Neuroendocrine, Endometrial Neoplasms, Leukemia, Myeloid, Acute, Lymphoma, T-Cell, Carcinoma, Hepatocellular, Melanoma, Carcinoma, Non-Small-Cell Lung

PF-06823859

PF-06823859

Phase 2 Clinical

Pfizer Pharmaceuticals Ltd (China)

Dermatomyositis, Lupus Erythematosus, Systemic

MEM-288

MEM-288

Phase 1 Clinical

Memgen

Head and Neck Neoplasms, Solid tumours, Carcinoma, Merkel Cell, Triple Negative Breast Neoplasms, Pancreatic Neoplasms, Carcinoma, Squamous Cell, Melanoma, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

VSV-hIFNbeta-NIS (University of Tennessee)

Phase 1 Clinical

The University Of Tennessee

Multiple Myeloma, Leukemia, Myeloid, Acute, Endometrial Neoplasms, Lymphoma, T-Cell

Interferon beta-1b biosimilar(Biocure Technology)

Preclinical

Multiple Sclerosis

Interferon beta-1a (Nastech)

Pending

Nastech Pharmaceutical Company

Multiple Sclerosis

TA-383

TA-383

Pending

Mitsubishi Tanabe Pharma

Arthritis, Rheumatoid

References


Title

Authors

Source

Human fibroblast interferon gene lacks introns

Lawn R.M., Adelman J., Franke A.E., Houck C.M., Gross M., Najarian R., Goeddel D.V.,

Nucleic Acids Res. 9:1045-1052(1981)

Structure of a chromosomal gene for human interferon beta

Ohno S., Taniguchi T.,

Proc. Natl. Acad. Sci. U.S.A. 78:5305-5309(1981)

On the relationship between human interferon alpha 1 and beta 1 genes

May L.T., Sehgal P.B.,

J. Interferon Res. 5:521-526(1985)

Human protein factory for converting the transcriptome into an in vitro-expressed proteome

Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B., Nomura N.,

Nat. Methods 5:1011-1017(2008)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers

Houghton M., Stewart A.G., Doel S.M., Emtage J.S., Eaton M.A.W., Smith J.C., Patel T.P., Lewis H.M., Porter A.G., Birch J.R., Cartwright T., Carey N.H.,

Nucleic Acids Res. 8:1913-1931(1980)

Assignment of the disulphide bonds of leukocyte interferon

Wetzel R.,

Nature 289:606-607(1981)

A single amino acid change in IFN-beta1 abolishes its antiviral activity

Shepard H.M., Leung D., Stebbing N., Goeddel D.V.,

Nature 294:563-565(1981)

The crystal structure of human interferon beta at 2.2-A resolution

Karpusas M., Nolte M., Benton C.B., Meier W., Lipscomb W.N., Goelz S.,

Proc. Natl. Acad. Sci. U.S.A. 94:11813-11818(1997)

The consensus coding sequences of human breast and colorectal cancers

Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Velculescu V.E.,

Science 314:268-274(2006)