Interferon gamma-inducing factor, IL-18, IFN-gamma-inducing factor, IGIF, Iboctadekin, IL18, Interleukin 18, Interleukin 18 (Interferon-Gamma-Inducing Factor), Interleukin-1 Gamma, IL-1 Gamma, IL1F4, Interferon-Gamma-Inducing Factor, Interleukin-18, IL-1g


Interleukin 18 is a protein which in humans is encoded by the IL18 gene.The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to produce IL-18.A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators . Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) .

KO Status

RenMab: Immunization

Drug Information

Drugs in clinical trials: 4
Latest Research Phase: Phase 3 Clinical

Drug Name





Clinical Trials

Tadekinig alfa (AB2 Bio)

Phase 3 Clinical

Ab2 Bio

Macrophage Activation Syndrome, Immune System Diseases



Phase 2 Clinical

Glaxosmithkline Plc

Rejection of renal transplantation, Inflammatory Bowel Diseases, Delayed Graft Function, Diabetes Mellitus, Dermatitis, Atopic



Phase 2 Clinical

Novartis Pharma Ag

Sarcoidosis, Pulmonary, Dermatitis, Atopic


MEDI-2338, CERC-007, AEVI-007

Phase 1 Clinical

Medimmune Llc

Still's Disease, Adult-Onset, Autoimmune Diseases, Multiple Myeloma, Pulmonary Disease, Chronic Obstructive




Novartis Pharma Ag, Morphosys


Tadekinig alfa (Yeda Research and Development Company)


Yeda Pharma

Arthritis, Rheumatoid, Autoimmune Diseases, Psoriasis, Crohn Disease




Ligand Pharmaceuticals Inc

Respiratory Tract Diseases





Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein

Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., Tanabe F., Konishi K., Micallef M., Fujii M., Torigoe K., Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M.,

J. Immunol. 156:4274-4279(1996)

A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing

Gaggero A., De Ambrosis A., Mezzanzanica D., Piazza T., Rubartelli A., Figini M., Canevari S., Ferrini S.,

Oncogene 23:7552-7560(2004)

Human chromosome 11 DNA sequence and analysis including novel gene identification

Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,

Nature 440:497-500(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

Tominaga K., Yoshimoto T., Torigoe K., Kurimoto M., Matsui K., Hada T., Okamura H., Nakanishi K.,

Int. Immunol. 12:151-160(2000)

Initial characterization of the human central proteome

Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.,

BMC Syst. Biol. 5:17-17(2011)

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

Jourdan T., Godlewski G., Cinar R., Bertola A., Szanda G., Liu J., Tam J., Han T., Mukhopadhyay B., Skarulis M.C., Ju C., Aouadi M., Czech M.P., Kunos G.,

Nat. Med. 19:1132-1140(2013)

The structure and binding mode of interleukin-18

Kato Z., Jee J., Shikano H., Mishima M., Ohki I., Ohnishi H., Li A., Hashimoto K., Matsukuma E., Omoya K., Yamamoto Y., Yoneda T., Hara T., Kondo N., Shirakawa M.,

Nat. Struct. Biol. 10:966-971(2003)

Structural basis for the specific recognition of IL-18 by its alpha receptor

Wei H., Wang D., Qian Y., Liu X., Fan S., Yin H.S., Wang X.,

FEBS Lett. 588:3838-3843(2014)

The structural basis for receptor recognition of human interleukin-18

Tsutsumi N., Kimura T., Arita K., Ariyoshi M., Ohnishi H., Yamamoto T., Zuo X., Maenaka K., Park E.Y., Kondo N., Shirakawa M., Tochio H., Kato Z.,

Nat. Commun. 5:5340-5340(2014)