IL1A

Synonyms

IL1A, IL1F1, IL-1 alpha, Interleukin 1 Alpha, Hematopoietin-1, Pro-Interleukin-1-Alpha, Preinterleukin 1 Alpha, IL1-ALPHA, IL-1A, IL1, Interleukin-1alpha, Interleukin-1 Alpha

Description

Interleukin-1 alpha (IL1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that produced mainly by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

KO Status

Immunization

Drug Information

Launched drug: 1
Drugs in clinical trials: 5
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Rilonacept

KPL-914, RGN-303

Approved

Regeneron Pharmaceuticals Inc

Anemia, Muckle-Wells Syndrome (MWS), Genetic Diseases, Inborn, Arthritis, Juvenile, Hyperlipoproteinemia Type I, Pericarditis, Cryopyrin-Associated Periodic Syndromes, Gout, Renal Insufficiency, Chronic

Bermekimab (XBiotech)

CV-18C3, CA-18C3, MABP-1, MABp1, JNJ-77474462, MAB-p1, RA-18C3, T2-18C3

NDA/BLA

Xbiotech

Hematologic Neoplasms, Acne Vulgaris, Pyoderma Gangrenosum, Diabetes Mellitus, Type 2, Psoriasis, Colorectal Neoplasms, Hidradenitis Suppurativa, Dermatitis, Atopic, Eczema

Tadekinig alfa (AB2 Bio)

Phase 3 Clinical

Ab2 Bio

Macrophage Activation Syndrome, Immune System Diseases

AC-701

AC-701

Phase 2 Clinical

Twi Pharmaceuticals Inc

Rosacea, Exanthema

Interleukin-1 alpha (Amgen/Roche)

Clinical

Amgen Inc

Neutropenia, Hodgkin Disease, Radiation Injuries, Thrombocytopenia, Melanoma

ONC-92592

ONC-92592

Preclinical

Xbiotech

Neoplasms

CAR-90972

CAR-90972

Preclinical

Xbiotech

Brain Injuries

RHE-70202

RHE-70202

Preclinical

Xbiotech

Arthritis, Psoriatic

TA-383

TA-383

Pending

Mitsubishi Tanabe Pharma

Arthritis, Rheumatoid

lutikizumab

ABT-981

Pending

Abbvie Inc

Osteoarthritis, Knee, Osteoarthritis

References


Title

Authors

Source

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

March C.J., Mosley B., Larsen A., Cerretti D.P., Braedt G., Price V., Gillis S., Henney C.S., Kronheim S.R., Grabstein K., Conlon P.J., Hopp T.P., Cosman D.,

Nature 315:641-647(1985)

Complete nucleotide sequence of the gene for human interleukin 1 alpha

Furutani Y., Notake M., Fukui T., Ohue M., Nomura H., Yamada M., Nakamura S.,

Nucleic Acids Res. 14:3167-3179(1986)

Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor

Furutani Y., Notake M., Yamayoshi M., Yamagishi J., Nomura H., Ohue M., Furuta R., Fukui T., Yamada M., Nakamura S.,

Nucleic Acids Res. 13:5869-5882(1985)

Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta

Kotenko S.V., Bulenkov M.T., Veiko V.P., Epishin S.M., Lomakin I.B., Emel'Yanov A.V., Kozlov A.P., Konusova V.G., Kotov A.Y., Kurbatova T.V., Reshetnikov V.L., Simbirtsev A.S., Ketlinskii S.A., Vinetskii Y.P.,

Dokl. Akad. Nauk SSSR 309:1005-1008(1989)

Recombinant human interleukin 1 alpha: purification and biological characterization

Gubler U., Chua A.O., Stern A.S., Hellmann C.P., Vitek M.P., Dechiara T.M., Benjamin W.R., Collier K.J., Dukovich M., Familletti P.C., Fiedler-Nagy C., Jenson J., Kaffka K., Kilian P.L., Stremlo D., Wittreich B.H., Woehle D., Mizel S.B., Lomedico P.T.,

J. Immunol. 136:2492-2497(1986)

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

Nishida T., Nishino N., Takano M., Kawai K., Bando K., Masui Y., Nakai S., Hirai Y.,

Biochem. Biophys. Res. Commun. 143:345-352(1987)

A sequence-based map of the nine genes of the human interleukin-1 cluster

Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.,

Genomics 79:718-725(2002)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,

Nature 434:724-731(2005)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)