IL2RA

Synonyms

TAC antigen, p55, IL2-RA, Interleukin-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2RA, Interleukin 2 Receptor Subunit Alpha, Interleukin 2 Receptor, Alpha, IL-2 Receptor Subunit Alpha, CD25 Antigen, IDDM10, IMD41, TCGFR, CD25, IL2R, Insulin-Dependent Diabetes Mellitus 10, Interleukin-2 Receptor alpha Subunit

Description

Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

KO Status

F2 (-/-)

Drug Information

Launched drugs: 4
Drugs in clinical trials: 4
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Daclizumab

R-35, BIIB-019, RO-247375

Approved

Abbvie Inc, Biogen Inc, F. Hoffmann-La Roche Ltd

Multiple Sclerosis, Relapsing-Remitting, Gastrointestinal Diseases, Inflammatory Bowel Diseases, Multiple Sclerosis, Rejection of organ transplantation, Asthma, Colitis, Ulcerative

Recombinant humanized anti-CD25 monoclonal antibody (Shanghai CP Guojian)

Approved

Shanghai Cp Guojian Pharmaceutical Co Ltd

Rejection of renal transplantation

Denileukin diftitox

E-7272, E-7777, DAB-389, LY-335348, DAB389IL-2

Approved

Eisai Co Ltd

Lymphoma, B-Cell, Leukemia, Lymphoma, T-Cell, Peripheral, Lymphoma, Non-Hodgkin, Lymphoma, Lymphoma, T-Cell, Cutaneous, Leukemia, Lymphocytic, Chronic, B-Cell, Melanoma

Recombinant Human Interleukin-2(Ⅰ) (Liaoning Satellite Biological Products)

Approved

Liaoning Satellite Biological Products Research Institute (Limited)

Neoplasms

Basiliximab

CHT-25, chRFT5, CHI-621, SDZ-CHI-621

Approved

Novartis Pharma Ag

Rejection of renal transplantation, Rejection of organ transplantation, Colitis, Ulcerative, Uveitis

Basiliximab biobetter (Mabtech/Sorrento)

STI-003

Phase 3 Clinical

Taizhou Maibo Taike Biotechnology Co Ltd

Autoimmune Diseases

Inolimomab

B-B10, BT-563, MAb-BT-563

Phase 3 Clinical

Eusa Pharma, Jazz Pharmaceuticals

Graft vs Host Disease

Camidanlumab tesirine

ADCT-301

Phase 2 Clinical

Genmab, Adc Therapeutics

Lymphoma, T-Cell, Peripheral, Solid tumours, Ovarian Neoplasms, Carcinoma, Renal Cell, Esophageal Neoplasms, Stomach Neoplasms, Squamous Cell Carcinoma of Head and Neck, Lymphoma, Large B-Cell, Diffuse, Hodgkin Disease, Triple Negative Breast Neoplasms, Pancreatic Neoplasms, Urinary Bladder Neoplasms, Lymphoma, Follicular, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Colorectal Neoplasms, Burkitt Lymphoma, Leukemia, Myeloid, Acute, Lymphoma, Lymphoma, Non-Hodgkin, Lymphoma, T-Cell, Cutaneous, Waldenstrom Macroglobulinemia, Fallopian Tube Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Melanoma, Carcinoma, Non-Small-Cell Lung

ANV-419

Phase 2 Clinical

Anaveon AG

Solid tumours

Anti-interleukin-2 receptor monoclonal antibody Mikbeta1

HuMikβ1-1

Phase 1 Clinical

F. Hoffmann-La Roche Ltd, National Institutes Of Health

Leukemia, Lymphoid

References


Title

Authors

Source

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor

Stauber D.J., Debler E.W., Horton P.A., Smith K.A., Wilson I.A.,

Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006)

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

Lowe C.E., Cooper J.D., Brusko T., Walker N.M., Smyth D.J., Bailey R., Bourget K., Plagnol V., Field S., Atkinson M., Clayton D.G., Wicker L.S., Todd J.A.,

Nat. Genet. 39:1074-1082(2007)

Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity

Goudy K., Aydin D., Barzaghi F., Gambineri E., Vignoli M., Ciullini Mannurita S., Doglioni C., Ponzoni M., Cicalese M.P., Assanelli A., Tommasini A., Brigida I., Dellepiane R.M., Martino S., Olek S., Aiuti A., Ciceri F., Roncarolo M.G., Bacchetta R.,

Clin. Immunol. 146:248-261(2013)

Follicular bronchiolitis as phenotype associated with CD25 deficiency

Bezrodnik L., Caldirola M.S., Seminario A.G., Moreira I., Gaillard M.I.,

Clin. Exp. Immunol. 175:227-234(2014)

Molecular cloning of cDNA encoding human interleukin-2 receptor

Nikaido T., Shimizu A., Ishida N., Sabe H., Teshigawara K., Maeda M., Uchiyama T., Yodoi J., Honjo T.,

Nature 311:631-635(1984)

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

Leonard W.J., Depper J.M., Crabtree G.R., Rudikoff S., Pumphrey J., Robb R.J., Kroenke M., Svetlik P.B., Peffer N.J., Waldmann T.A., Greene W.C.,

Nature 311:626-631(1984)

Molecular cloning and structure of the human interleukin 2 receptor gene

Ishida N., Kanamori H., Noma T., Nikaido T., Sabe H., Suzuki N., Shimizu A., Honjo T.,

Nucleic Acids Res. 13:7579-7589(1985)

Structure of the human interleukin-2 receptor gene

Leonard W.J., Depper J.M., Kanehisa M., Kroenke M., Peffer N.J., Svetlik P.B., Sullivan M., Greene W.C.,

Science 230:633-639(1985)

The DNA sequence and comparative analysis of human chromosome 10

Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Rogers J.,

Nature 429:375-381(2004)

Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I

Cross S.L., Feinberg M.B., Wolf J.B., Holbrook N.J., Wong-Stall F., Leonard W.J.,

Cell 49:47-56(1987)