IL5

Synonyms

T-cell replacing factor, IL5, Interleukin 5, Eosinophil Differentiation Factor, Colony-Stimulating Factor, Eosinophil, B-Cell Differentiation Factor I, Interleukin-5, IL-5, TRF, Interleukin 5 (Colony-Stimulating Factor, Eosinophil), B Cell Differentiation Factor I, EDF

Description

Interleukin-5 induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

KO Status

F2 (-/-)

Drug Information

Launched drugs: 2
Drugs in clinical trials: 4
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Reslizumab

TRFK-5, CDP-835, SCH-5570, CEP-38072, CTx-55700, SCH-55700

Approved

Teva Pharmaceutical Industries Ltd

Pulmonary Eosinophilia, Eosinophilic Esophagitis, Asthma

Mepolizumab

SB-240563, 240563

Approved

Glaxosmithkline Plc

Hypereosinophilic Syndrome, Granulomatosis with Polyangiitis, Churg-Strauss Syndrome, Nasal Polyps, Eosinophilic Esophagitis, Asthma, Eosinophilic Granuloma, Sinusitis, Pulmonary Disease, Chronic Obstructive, Dermatitis, Atopic

GSK-3511294

GSK-3511294, GSK-294, GSK3511294, GSK294

Phase 3 Clinical

Glaxosmithkline Plc

Asthma

Orismilast

LP-0058, LEO-32731

Phase 2 Clinical

Leo Pharma Inc

Drug-Related Side Effects and Adverse Reactions, Psoriasis, Dermatitis, Atopic

long-acting anti-IL-5 mAb (GSK)

Phase 1 Clinical

Glaxosmithkline Plc

Asthma

Recombinant anti-IL-5 humanized monoclonal antibody (Shanghai CP Guojian)

610

Phase 1 Clinical

Shanghai Cp Guojian Pharmaceutical Co Ltd

Autoimmune Diseases, Asthma

SHR-1703

SHR-1703

Phase 1 Clinical

Suzhou Suncadia Biopharmaceuticals Co Ltd, Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd

Asthma

GCC-AP0341

GCC-AP0341

Discontinued

Mitsubishi Tanabe Pharma

Asthma

References


Title

Authors

Source

Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)

Campbell H.D., Tucker W.Q.J., Hort Y., Martinson M.E., Mayo G., Clutterbuck E.J., Sanderson C.J., Young I.G.,

Proc. Natl. Acad. Sci. U.S.A. 84:6629-6633(1987)

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5

Yokota T., Coffman R.L., Hagiwara H., Rennick D.M., Takebe Y., Yokota K., Gemmell L., Shrader B., Yang G., Meyerson P., Luh J., Hoy P., Pene J., Briere F., Spits H., Banchereau J., de Vries J., Lee F.D., Arai N., Arai K.,

Proc. Natl. Acad. Sci. U.S.A. 84:7388-7392(1987)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells

Minamitake Y., Kodama S., Katayama T., Adachi H., Tanaka S., Tsujimoto M.,

J. Biochem. 107:292-297(1990)

Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein

Proudfoot A.E.I., Davies J.G., Turcatti G., Wingfield P.T.,

FEBS Lett. 283:61-64(1991)

A novel dimer configuration revealed by the crystal structure at 2.4-A resolution of human interleukin-5

Milburn M.V., Hassell A.M., Lambert M.H., Jordan S.R., Proudfoot A.E.I., Graber P., Wells T.N.C.,

Nature 363:172-176(1993)

Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha

Patino E., Kotzsch A., Saremba S., Nickel J., Schmitz W., Sebald W., Mueller T.D.,

Structure 19:1864-1875(2011)

Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue

Azuma C., Tanabe T., Konishi M., Kinashi T., Noma T., Matsuda F., Yaoita Y., Takatsu K., Hammarstroem L., Smith C.I.E., Severinson E., Honjo T.,

Nucleic Acids Res. 14:9149-9158(1986)

Molecular cloning and structure of the human interleukin-5 gene

Tanabe T., Konishi M., Mizuta T., Noma T., Honjo T.,

J. Biol. Chem. 262:16580-16584(1987)