T-cell replacing factor, IL5, Interleukin 5, Eosinophil Differentiation Factor, Colony-Stimulating Factor, Eosinophil, B-Cell Differentiation Factor I, Interleukin-5, IL-5, TRF, Interleukin 5 (Colony-Stimulating Factor, Eosinophil), B Cell Differentiation Factor I, EDF

KO Status

RenMab: In Vitro

Drug Information

Launched drugs: 2
Drugs in clinical trials: 6
Latest Research Phase: Approved

Drug Name





Clinical Trials


TRFK-5, CDP-835, SCH-5570, CEP-38072, CTx-55700, SCH-55700


Teva Pharmaceutical Industries Ltd

Pulmonary Eosinophilia, Eosinophilic Esophagitis, Asthma


SB-240563, 240563


Glaxosmithkline Plc

Hypereosinophilic Syndrome, Granulomatosis with Polyangiitis, Churg-Strauss Syndrome, Nasal Polyps, Eosinophilic Esophagitis, Asthma, Sinusitis, Eosinophilic Granuloma, Pulmonary Disease, Chronic Obstructive, Dermatitis, Atopic


GSK-3511294, GSK-294, GSK3511294, GSK294

Phase 3 Clinical

Glaxosmithkline Plc

Vasculitis, Asthma, Eosinophilic Granuloma


LP-0058, LEO-32731

Phase 2 Clinical

Leo Pharma Inc

Drug-Related Side Effects and Adverse Reactions, Psoriasis, Dermatitis, Atopic

long-acting anti-IL-5 mAb (GSK)

Phase 1 Clinical

Glaxosmithkline Plc


Recombinant anti-IL-5 humanized monoclonal antibody (Shanghai CP Guojian)


Phase 1 Clinical

Shanghai Cp Guojian Pharmaceutical Co Ltd

Autoimmune Diseases, Asthma



Phase 1 Clinical

Suzhou Suncadia Biopharmaceuticals Co Ltd, Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd


Mepolizumab biosimilar (CTTQ Pharma)


Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group




Psoriasis, Dermatitis, Atopic

Mepolizumab biosimilar(Bio Thera Solutions)


Bio-Thera Solutions Ltd





Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)

Campbell H.D., Tucker W.Q.J., Hort Y., Martinson M.E., Mayo G., Clutterbuck E.J., Sanderson C.J., Young I.G.,

Proc. Natl. Acad. Sci. U.S.A. 84:6629-6633(1987)

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5

Yokota T., Coffman R.L., Hagiwara H., Rennick D.M., Takebe Y., Yokota K., Gemmell L., Shrader B., Yang G., Meyerson P., Luh J., Hoy P., Pene J., Briere F., Spits H., Banchereau J., de Vries J., Lee F.D., Arai N., Arai K.,

Proc. Natl. Acad. Sci. U.S.A. 84:7388-7392(1987)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells

Minamitake Y., Kodama S., Katayama T., Adachi H., Tanaka S., Tsujimoto M.,

J. Biochem. 107:292-297(1990)

Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein

Proudfoot A.E.I., Davies J.G., Turcatti G., Wingfield P.T.,

FEBS Lett. 283:61-64(1991)

A novel dimer configuration revealed by the crystal structure at 2.4-A resolution of human interleukin-5

Milburn M.V., Hassell A.M., Lambert M.H., Jordan S.R., Proudfoot A.E.I., Graber P., Wells T.N.C.,

Nature 363:172-176(1993)

Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha

Patino E., Kotzsch A., Saremba S., Nickel J., Schmitz W., Sebald W., Mueller T.D.,

Structure 19:1864-1875(2011)

Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue

Azuma C., Tanabe T., Konishi M., Kinashi T., Noma T., Matsuda F., Yaoita Y., Takatsu K., Hammarstroem L., Smith C.I.E., Severinson E., Honjo T.,

Nucleic Acids Res. 14:9149-9158(1986)

Molecular cloning and structure of the human interleukin-5 gene

Tanabe T., Konishi M., Mizuta T., Noma T., Honjo T.,

J. Biol. Chem. 262:16580-16584(1987)