LTA

Synonyms

TNF Superfamily Member 1, TNLG1E, LT, Lymphotoxin-alpha, TNFSF1, Tumor Necrosis Factor Ligand Superfamily Member 1, Tumor Necrosis Factor Beta, LT-alpha, LTA#TNFB, LTA, Lymphotoxin Alpha, TNF-Beta, TNFB, Lymphotoxin Alpha (TNF Superfamily, Member 1), Tumor Necrosis Factor Ligand 1E, Truncated Lymphotoxin Alpha, TNF Superfamily, Member 1

Description

Tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. Belonging to the hematopoietic cell line, LT-α exhibits anti-proliferative activity and causes the cellular destruction of tumor cell lines. Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM . In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.

KO Status

RenMab: F0

Drug Information

Launched drugs: 14
Drugs in clinical trials: 4
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Etanercept biosimilar (Mylan)

YLB-113

Approved

Rubin Ltd, Mylan Nv

Arthritis, Rheumatoid, Spondylarthropathies, Spondylitis, Ankylosing, Arthritis, Juvenile, Arthritis, Psoriatic, Plaque psoriasis

Etanercept biosimilar (Hanwha Chemical)

HD-203, MK-8953

Approved

Hanwha Chemical

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic

Opinercept

E-11, ENIA-11

Approved

Tsh Biopharm, Mycenax Biotech Inc

Spondylitis, Ankylosing, Arthritis, Rheumatoid

Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals)

Approved

Hisun-Pfizer

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic

Etanercept biosimilar (Amega Biotech)

Approved

Amega Biotech

Arthritis, Rheumatoid

Etanercept biosimilar (Intas Biopharmaceuticals)

Approved

Intas Biopharmaceuticals

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Juvenile, Psoriasis, Arthritis, Psoriatic

Etanercept biosimilar (AryoGen Biopharma)

Approved

Aryogen Biopharma

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Juvenile, Psoriasis, Arthritis, Psoriatic

Etanercept biosimilar (Nanogen Biopharmaceutical)

Approved

Nanogen Biopharmaceutical Co

Arthritis, Rheumatoid, Psoriasis

Etanercept biosimilar (PROBIOMED)

Approved

Probiomed

Arthritis, Rheumatoid

Etanercept

TNR-001

Approved

Pfizer Pharmaceuticals Ltd (China), Amgen Inc

Arthritis, Rheumatoid, Spondylitis, Ankylosing, Arthritis, Juvenile, Pulmonary Fibrosis, Psoriasis, Arthritis, Psoriatic, Asthma, Inflammation, Arthritis, Plaque psoriasis

References


Title

Authors

Source

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production

Messer G., Spengler U., Jung M.C., Honold G., Bloemer K., Pape G.R., Riethmueller G., Weiss E.H.,

J. Exp. Med. 173:209-219(1991)

Haplotypic polymorphisms of the TNFB gene

Abraham L.J., Du D.C., Zahedi K., Dawkins R.L., Whitehead A.S.,

Immunogenetics 33:50-53(1991)

Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity

Balding J., Kane D., Livingstone W., Mynett-Johnson L., Bresnihan B., Smith O., FitzGerald O.,

Arthritis Rheum. 48:1408-1413(2003)

Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy

Alcaies A., Alter A., Antoni G., Orlova M., Nguyen V.T., Singh M., Vanderborght P.R., Katoch K., Mira M.T., Vu H.T., Ngyuen T.H., Nguyen N.B., Moraes M., Mehra N., Schurr E., Abel L.,

Nat. Genet. 39:517-522(2007)

Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome

Nedospasov S.A., Shakhov A.N., Turetskaya R.L., Mett V.A., Azizov M.M., Georgiev G.P., Korobko V.G., Dobrynin V.N., Filippov S.A., Bystrov N.S., Boldyreva E.F., Chuvpilo S.A., Chumakov A.M., Shingarova L.N., Ovchinnikov Y.A.,

Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986)

Structure and chromosomal localization of the human lymphotoxin gene

Nedwin G.E., Jarrett-Nedwin J., Smith D.H., Naylor S.L., Sakaguchi A.Y., Goeddel D.V., Gray P.W.,

J. Cell. Biochem. 29:171-181(1985)

Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma

Kobayashi Y., Miyamoto D., Asada M., Obinata M., Osawa T.,

J. Biochem. 100:727-733(1986)

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

Gray P.W., Aggarwal B.B., Benton C.V., Bringman T.S., Henzel W.J., Jarrett J.A., Leung D.W., Moffat B., Ng P., Svedersky L.P., Palladino M.A., Nedwin G.E.,

Nature 312:721-724(1984)

Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788

Matsuyama N., Okawa N., Tsukii Y., Endo T., Kaji A.,

FEBS Lett. 302:141-144(1992)

Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment

Iris F.J.M., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V., Jurka J., Rodriguez-Tome P., Claverie J.-M., Dausset J., Cohen D.,

Nat. Genet. 3:137-145(1993)