MMP-2
Synonyms
MMP-2, MMP2, Matrix metalloproteinase-2, 72 kDa gelatinase, Matrix Metallopeptidase 2, CLG4A, TBE-1, Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase), Matrix Metalloproteinase 2, Matrix Metalloproteinase-II, 72 KDa Type IV Collagenase, Collagenase Type IV-A, Neutrophil Gelatinase, Gelatinase A, EC 3.4.24.24, MMP-II, MONA, CLG4, EC 3.4.24, EC:3.4.24.24, Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase),Description
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, it can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. It cleaves KISS at a Gly-|-Leu bond and appears to have a role in myocardial cell death pathways. It contributes to myocardial oxidative stress by regulating the activity of GSK3beta and cleaves GSK3beta in vitro. It is involved in the formation of the fibrovascular tissues in association with MMP14.
KO Status
F0
Drug Information
Launched drug: 1
Drug in clinical trials: 1
Latest Research Phase:Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Abametapir
HA-44, DFD-11, Ha44 Gel, BRN-0123183
Approved
Hatchtech
Lice Infestations
AQU-005
AQU-005, NMAQU-005, NM-AQU-005
Phase 1 Clinical
Aquilus Pharmaceuticals
Neuralgia
PNU-248686A
PNU-248686A
Pending
Pfizer Pharmaceuticals Ltd (China)
Neoplasms
S-3304
S-3304
Pending
Shionogi & Co Ltd
Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
Incyclinide
CMT-3, COL-3, NSC-683551
Discontinued
Galderma
Acne Vulgaris, Rosacea
SD-7300
Discontinued
Pfizer Pharmaceuticals Ltd (China)
Neoplasms
XL-784
XL-784
Discontinued
Exelixis
Albuminuria, Diabetic Nephropathies
ABT-518
ABT 518
Discontinued
Abbvie Inc
Neoplasms
AE-941
AE-941, NSC-706456
Discontinued
Aeterna Zentaris
Kidney Neoplasms, Carcinoma, Renal Cell, Carcinoma, Non-Small-Cell Lung
RS-130830
CTS-1027, RS-130830, RO-1130830
Discontinued
F. Hoffmann-La Roche Ltd
Hepatitis C, Arthritis, Hepatitis C, Chronic
Rebimastat
D-2163, BMS-275291
Discontinued
Celltech
Breast Neoplasms, Carcinoma, Non-Small-Cell Lung
Tanomastat
BAY-12-9566
Discontinued
Bayer Ag
Ovarian Neoplasms, Pancreatic Neoplasms, Small Cell Lung Carcinoma, Carcinoma, Non-Small-Cell Lung
PG-116800
PG-116800, PG-530742, PGE-7113313
Discontinued
Procter & Gamble
Heart Failure, Myocardial Infarction, Cardiomegaly, Osteoarthritis, Knee, Osteoarthritis
131-I-Chlorotoxin
131-I-TM-601, TM-601-I-131
Discontinued
Transmolecular
Glioblastoma, Oligodendroglioma, Brain Neoplasms, Astrocytoma, Gliosarcoma, Glioma, Melanoma