MMP-2

Synonyms

MMP-2, MMP2, Matrix metalloproteinase-2, 72 kDa gelatinase, Matrix Metallopeptidase 2, CLG4A, TBE-1, Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase), Matrix Metalloproteinase 2, Matrix Metalloproteinase-II, 72 KDa Type IV Collagenase, Collagenase Type IV-A, Neutrophil Gelatinase, Gelatinase A, EC 3.4.24.24, MMP-II, MONA, CLG4, EC 3.4.24, EC:3.4.24.24, Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase),

Description

72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, it can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. It cleaves KISS at a Gly-|-Leu bond and appears to have a role in myocardial cell death pathways. It contributes to myocardial oxidative stress by regulating the activity of GSK3beta and cleaves GSK3beta in vitro. It is involved in the formation of the fibrovascular tissues in association with MMP14.

KO Status

F0

Drug Information

Launched drug: 1
Drug in clinical trials: 1
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Abametapir

HA-44, DFD-11, Ha44 Gel, BRN-0123183

Approved

Hatchtech

Lice Infestations

AQU-005

AQU-005, NMAQU-005, NM-AQU-005

Phase 1 Clinical

Aquilus Pharmaceuticals

Neuralgia

PNU-248686A

PNU-248686A

Pending

Pfizer Pharmaceuticals Ltd (China)

Neoplasms

S-3304

S-3304

Pending

Shionogi & Co Ltd

Lung Neoplasms, Carcinoma, Non-Small-Cell Lung

Incyclinide

CMT-3, COL-3, NSC-683551

Discontinued

Galderma

Acne Vulgaris, Rosacea

SD-7300

Discontinued

Pfizer Pharmaceuticals Ltd (China)

Neoplasms

XL-784

XL-784

Discontinued

Exelixis

Albuminuria, Diabetic Nephropathies

ABT-518

ABT 518

Discontinued

Abbvie Inc

Neoplasms

AE-941

AE-941, NSC-706456

Discontinued

Aeterna Zentaris

Kidney Neoplasms, Carcinoma, Renal Cell, Carcinoma, Non-Small-Cell Lung

RS-130830

CTS-1027, RS-130830, RO-1130830

Discontinued

F. Hoffmann-La Roche Ltd

Hepatitis C, Arthritis, Hepatitis C, Chronic

Rebimastat

D-2163, BMS-275291

Discontinued

Celltech

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung

Tanomastat

BAY-12-9566

Discontinued

Bayer Ag

Ovarian Neoplasms, Pancreatic Neoplasms, Small Cell Lung Carcinoma, Carcinoma, Non-Small-Cell Lung

PG-116800

PG-116800, PG-530742, PGE-7113313

Discontinued

Procter & Gamble

Heart Failure, Myocardial Infarction, Cardiomegaly, Osteoarthritis, Knee, Osteoarthritis

131-I-Chlorotoxin

131-I-TM-601, TM-601-I-131

Discontinued

Transmolecular

Glioblastoma, Oligodendroglioma, Brain Neoplasms, Astrocytoma, Gliosarcoma, Glioma, Melanoma