NCL

Synonyms

NCL, Nucleolin, Protein C23, Nsr1, C23

Description

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel Laureates Rita Levi-Montalcini and Stanley Cohen in 1956, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system.

KO Status

RenMab: F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 3
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Recombinant human endostatin (Simcere)

YH-16

Approved

Jiangsu Xiansheng Pharmaceutical Co Ltd

Esophageal Neoplasms, Ascites, Osteosarcoma, Brain metastases, Pleural Effusion, Malignant, Carcinoma, Non-Small-Cell Lung

IPP-204106

N6L, Nucant-6L, IPP-204106, IPP-204106N, poyplexed IPP-204106

Phase 2 Clinical

Immupharma Plc

Neoplasms

AS-1411

AGRO-100, GR-026-B, AS-1411, ACT-GRO-777

Phase 2 Clinical

University Of Louisville, Antisoma, University Of Alabama At Birmingham

Solid tumours, Neoplasms

Pegylated recombinant human endostatin (Tsinghua University)

M-2ES

Phase 1 Clinical

Tsinghua University, Beijing Protgen Biotechnology Development Co Ltd

Solid tumours, Pancreatic Neoplasms, Neoplasms, Carcinoma, Non-Small-Cell Lung

AS1411-GNP

Preclinical

University Of Louisville

Precursor Cell Lymphoblastic Leukemia-Lymphoma

APTA-16

APTA-16, SJP1604

Preclinical

Aptabio Therapeutics

Liver Neoplasms, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

Doxorubicin (PEGASEMP/encapsulated nanoparticle formulation, cancer)

Preclinical

Mesothelioma, Breast Neoplasms

References


Title

Authors

Source

Cloning and sequencing of the human nucleolin cDNA

Srivastava M., Fleming P.J., Pollard H.B., Burns A.L.,

FEBS Lett. 250:99-105(1989)

Genomic organization and chromosomal localization of the human nucleolin gene

Srivastava M., McBride O.W., Fleming P.J., Pollard H.B., Burns A.L.,

J. Biol. Chem. 265:14922-14931(1990)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity

Guderian G., Peter C., Wiesner J., Sickmann A., Schulze-Osthoff K., Fischer U., Grimmler M.,

J. Biol. Chem. 286:1976-1986(2011)

Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal

Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H.,

J. Biol. Chem. 286:21732-21741(2011)

The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles

Ma N., Matsunaga S., Morimoto A., Sakashita G., Urano T., Uchiyama S., Fukui K.,

J. Cell Sci. 124:394-404(2011)

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination

Skourti-Stathaki K., Proudfoot N.J., Gromak N.,

Mol. Cell 42:794-805(2011)

Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles

Yoshikawa H., Komatsu W., Hayano T., Miura Y., Homma K., Izumikawa K., Ishikawa H., Miyazawa N., Tachikawa H., Yamauchi Y., Isobe T., Takahashi N.,

Mol. Cell. Proteomics 10:0-0(2011)

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation

Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.,

Sci. Signal. 4:RS3-RS3(2011)

Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21

Hirai Y., Louvet E., Oda T., Kumeta M., Watanabe Y., Horigome T., Takeyasu K.,

Genes Cells 18:780-797(2013)