PRLR

Synonyms

PRL-R, PRLR, Prolactin Receptor, Secreted Prolactin Binding Protein, HPRL Receptor, RI-PRLR, HPRLrI, HPRL, MFAB, Receptors, Prolactin,

Description

The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. The PRLR binds prolactin (PRL) as a transmembrane receptor. Thus the PRLR contains an extracellular region to bind PRL, a transmembrane region, and a cytoplasmatic region. The PRLR can also bind to and be activated by growth hormone (GH) and human placental lactogen (hPL), in addition to prolactin. Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

KO Status

F0

Drug Information

Launched drugs: 2
Drugs in clinical trials: 0
Latest Research Phase:Phase 1 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Cancer therapeutics (Ipsen)

Preclinical

Ipsen

Neoplasms

Rolinsatamab talirine

h16f, ABBV-176, DC-1630993

Phase 1 Clinical

Abbvie Inc

Neoplasms

BAY-1158061

BAY-1158061

Phase 1 Clinical

Bayer Ag

Endometriosis

Prolanta(Oncolix)

Pending

Oncolix

Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms

NTx-488

NTx-488

Discontinued

Trillium Therapeutics Inc

Multiple Sclerosis

XOMA-213

X-213, LFA-102, XOMA-213

Discontinued

Xoma

Prostatic Neoplasms, Breast Neoplasms, Leiomyoma