PRL-R, PRLR, Prolactin Receptor, Secreted Prolactin Binding Protein, HPRL Receptor, RI-PRLR, HPRLrI, HPRL, MFAB, Receptors, Prolactin


The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. The PRLR binds prolactin (PRL) as a transmembrane receptor. Thus the PRLR contains an extracellular region to bind PRL, a transmembrane region, and a cytoplasmatic region. The PRLR can also bind to and be activated by growth hormone (GH) and human placental lactogen (hPL), in addition to prolactin. Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

KO Status

RenMab: F2 (-/-)

Drug Information

Drugs in clinical trials: 2
Latest Research Phase: Phase 1 Clinical

Drug Name





Clinical Trials

Rolinsatamab talirine

h16f, ABBV-176, DC-1630993

Phase 1 Clinical

Abbvie Inc




Phase 1 Clinical

Bayer Ag


Cancer therapeutics (Ipsen)







Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms


X-213, LFA-102, XOMA-213



Prostatic Neoplasms, Breast Neoplasms, Leiomyoma




Trillium Therapeutics Inc

Multiple Sclerosis





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The DNA sequence and comparative analysis of human chromosome 5

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Nature 431:268-274(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines

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Mol. Endocrinol. 19:939-949(2005)

Crystal structure and site 1 binding energetics of human placental lactogen

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J. Mol. Biol. 358:773-784(2006)

The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells

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Mol. Endocrinol. 20:2406-2417(2006)

Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors

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Proc. Natl. Acad. Sci. U.S.A. 105:14533-14538(2008)

Mutant prolactin receptor and familial hyperprolactinemia

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N. Engl. J. Med. 369:2012-2020(2013)

The X-ray structure of a growth hormone-prolactin receptor complex

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Nature 372:478-481(1994)