PRLR
Synonyms
PRL-R, PRLR, Prolactin Receptor, Secreted Prolactin Binding Protein, HPRL Receptor, RI-PRLR, HPRLrI, HPRL, MFAB, Receptors, Prolactin
Description
The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. The PRLR binds prolactin (PRL) as a transmembrane receptor. Thus the PRLR contains an extracellular region to bind PRL, a transmembrane region, and a cytoplasmatic region. The PRLR can also bind to and be activated by growth hormone (GH) and human placental lactogen (hPL), in addition to prolactin. Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
KO Status
RenMab: F2 (-/-)
Drug Information
Drugs in clinical trials: 2
Latest Research Phase: Phase 1 Clinical
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Rolinsatamab talirine
h16f, ABBV-176, DC-1630993
Phase 1 Clinical
Abbvie Inc
Neoplasms
BAY-1158061
BAY-1158061
Phase 1 Clinical
Bayer Ag
Endometriosis
Cancer therapeutics (Ipsen)
Preclinical
Ipsen
Neoplasms
Prolanta(Oncolix)
Pending
Oncolix
Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms
XOMA-213
X-213, LFA-102, XOMA-213
Discontinued
Xoma
Prostatic Neoplasms, Breast Neoplasms, Leiomyoma
NTx-488
NTx-488
Discontinued
Trillium Therapeutics Inc
Multiple Sclerosis
References
Title
Authors
Source
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Genome Res. 14:2121-2127(2004)
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Mol. Endocrinol. 19:939-949(2005)
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Nature 372:478-481(1994)