PRLR
Synonyms
PRL-R, PRLR, Prolactin Receptor, Secreted Prolactin Binding Protein, HPRL Receptor, RI-PRLR, HPRLrI, HPRL, MFAB, Receptors, Prolactin
Description
The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. The PRLR binds prolactin (PRL) as a transmembrane receptor. Thus the PRLR contains an extracellular region to bind PRL, a transmembrane region, and a cytoplasmatic region. The PRLR can also bind to and be activated by growth hormone (GH) and human placental lactogen (hPL), in addition to prolactin. Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
KO Status
RenMab: Antibody Discovery
Drug Information
Drugs in clinical trials: 2
Latest Research Phase: Phase 1 Clinical
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Rolinsatamab talirine
h16f, ABBV-176, DC-1630993
Phase 1 Clinical
Abbvie Inc
Solid tumours, Neoplasms
BAY-1158061
BAY-1158061
Phase 1 Clinical
Bayer Ag
Endometriosis
Cancer therapeutics (Ipsen)
Preclinical
Ipsen
Neoplasms
Prolanta(Oncolix)
Pending
Oncolix
Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms
NTx-488
NTx-488
Discontinued
Trillium Therapeutics Inc
Multiple Sclerosis
XOMA-213
X-213, LFA-102, XOMA-213
Discontinued
Xoma
Prostatic Neoplasms, Castration-Resistant, Prostatic Neoplasms, Breast Neoplasms, Leiomyoma
References
Title
Authors
Source
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
Nat. Genet. 36:40-45(2004)
The DNA sequence and comparative analysis of human chromosome 5
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Rubin E.M.,
Nature 431:268-274(2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines
Fuh G., Wells J.A.,
J. Biol. Chem. 270:13133-13137(1995)
Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor
Miller S.L., DeMaria J.E., Freier D.O., Riegel A.M., Clevenger C.V.,
Mol. Endocrinol. 19:939-949(2005)
Crystal structure and site 1 binding energetics of human placental lactogen
Walsh S.T., Kossiakoff A.A.,
J. Mol. Biol. 358:773-784(2006)
The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells
Lazzaro M.A., Pepin D., Pescador N., Murphy B.D., Vanderhyden B.C., Picketts D.J.,
Mol. Endocrinol. 20:2406-2417(2006)
Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors
Bogorad R.L., Courtillot C., Mestayer C., Bernichtein S., Harutyunyan L., Jomain J.B., Bachelot A., Kuttenn F., Kelly P.A., Goffin V., Touraine P., Bachelot A., Belaroussi B., Bensimhon J., Berdah J., Blin M.J., Boudinet A., Brethon B., Yacoub S.,
Proc. Natl. Acad. Sci. U.S.A. 105:14533-14538(2008)
Mutant prolactin receptor and familial hyperprolactinemia
Newey P.J., Gorvin C.M., Cleland S.J., Willberg C.B., Bridge M., Azharuddin M., Drummond R.S., van der Merwe P.A., Klenerman P., Bountra C., Thakker R.V.,
N. Engl. J. Med. 369:2012-2020(2013)
The X-ray structure of a growth hormone-prolactin receptor complex
Somers W., Ultsch M., de Vos A.M., Kossiakoff A.A.,
Nature 372:478-481(1994)