PRLR

Synonyms

PRL-R, PRLR, Prolactin Receptor, Secreted Prolactin Binding Protein, HPRL Receptor, RI-PRLR, HPRLrI, HPRL, MFAB, Receptors, Prolactin

Description

The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. The PRLR binds prolactin (PRL) as a transmembrane receptor. Thus the PRLR contains an extracellular region to bind PRL, a transmembrane region, and a cytoplasmatic region. The PRLR can also bind to and be activated by growth hormone (GH) and human placental lactogen (hPL), in addition to prolactin. Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

KO Status

F1 (+/-)

Drug Information

Drugs in clinical trials: 2
Latest Research Phase: Phase 1 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Rolinsatamab talirine

h16f, ABBV-176, DC-1630993

Phase 1 Clinical

Abbvie Inc

Neoplasms

BAY-1158061

BAY-1158061

Phase 1 Clinical

Bayer Ag

Endometriosis

Cancer therapeutics (Ipsen)

Preclinical

Ipsen

Neoplasms

Prolanta(Oncolix)

Pending

Oncolix

Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms

NTx-488

NTx-488

Discontinued

Trillium Therapeutics Inc

Multiple Sclerosis

XOMA-213

X-213, LFA-102, XOMA-213

Discontinued

Xoma

Prostatic Neoplasms, Breast Neoplasms, Leiomyoma

References


Title

Authors

Source

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and comparative analysis of human chromosome 5

Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Rubin E.M.,

Nature 431:268-274(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines

Fuh G., Wells J.A.,

J. Biol. Chem. 270:13133-13137(1995)

Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor

Miller S.L., DeMaria J.E., Freier D.O., Riegel A.M., Clevenger C.V.,

Mol. Endocrinol. 19:939-949(2005)

Crystal structure and site 1 binding energetics of human placental lactogen

Walsh S.T., Kossiakoff A.A.,

J. Mol. Biol. 358:773-784(2006)

The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells

Lazzaro M.A., Pepin D., Pescador N., Murphy B.D., Vanderhyden B.C., Picketts D.J.,

Mol. Endocrinol. 20:2406-2417(2006)

Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors

Bogorad R.L., Courtillot C., Mestayer C., Bernichtein S., Harutyunyan L., Jomain J.B., Bachelot A., Kuttenn F., Kelly P.A., Goffin V., Touraine P., Bachelot A., Belaroussi B., Bensimhon J., Berdah J., Blin M.J., Boudinet A., Brethon B., Yacoub S.,

Proc. Natl. Acad. Sci. U.S.A. 105:14533-14538(2008)

Mutant prolactin receptor and familial hyperprolactinemia

Newey P.J., Gorvin C.M., Cleland S.J., Willberg C.B., Bridge M., Azharuddin M., Drummond R.S., van der Merwe P.A., Klenerman P., Bountra C., Thakker R.V.,

N. Engl. J. Med. 369:2012-2020(2013)

The X-ray structure of a growth hormone-prolactin receptor complex

Somers W., Ultsch M., de Vos A.M., Kossiakoff A.A.,

Nature 372:478-481(1994)