SIRPɑ

Synonyms

SHPS-1, Macrophage fusion receptor, Brain Ig-like molecule with tyrosine-based activation motifs, MFR, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, CD172a, MyD-1 antigen, Sirp-alpha-3, MYD1, SIRPA, Signal Regulatory Protein Alpha, CD172 Antigen-Like Family Member A, Inhibitory Receptor SHPS-1, PTPNS1, SHPS1, SIRP, P84, Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs, Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1, Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, Tyrosine Phosphatase SHP Substrate 1, Signal-Regulatory Protein Alpha-3, Signal-Regulatory Protein Alpha, SHP Substrate 1, CD172a Antigen, Sirp-Alpha-1, Sirp-Alpha-2, MYD-1, Bit, SIRPalpha, SIRPalpha2

KO Status

RenMab: Antibody Discovery

Drug Information

Launched drug: 1
Drugs in clinical trials: 4
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Relugolix/Estradiol/Norethindrone Acetate

Approved

Myovant Sciences

Leiomyoma, Menorrhagia

Elagolix/estradiol/norethindrone acetate

Approved

Abbvie Inc

Menorrhagia

ALX-148

ALX148, ALX-148

Phase 2 Clinical

Alexo Therapeutics

Head and Neck Neoplasms, Solid tumours, Squamous Cell Carcinoma of Head and Neck, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Lymphoma, Non-Hodgkin, Neoplasm Metastasis

CC-95251

CC-95251

Phase 1 Clinical

Celgene Corp

Hematologic Neoplasms

BI-765063

OSE-172, BI-765063

Phase 1 Clinical

Ose Immunotherapeutics

Solid tumours

ES-004

ES-004

Preclinical

Elpiscience (Shanghai) Biopharma Ltd

Neoplasms

CTX-5861

CTX-5861

Preclinical

Compass Therapeutics LLC

Neoplasms

APX-700

APX-700

Preclinical

Epitomics

Neoplasms

AL-008

AL-008

Preclinical

Alector

Neoplasms

APX-701

APX-701

Preclinical

Apexigen

Neoplasms

References


Title

Authors

Source

Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes

Yamao T., Matozaki T., Amano K., Matsuda Y., Takahashi N., Ochi F., Fujioka Y., Kasuga M.,

Biochem. Biophys. Res. Commun. 231:61-67(1997)

A family of proteins that inhibit signalling through tyrosine kinase receptors

Kharitonenkov A., Chen Z., Sures I., Wang H., Schilling J., Ullrich A.,

Nature 386:181-186(1997)

Gene structure of mouse BIT/SHPS-1

Sano S., Ohnishi H., Kubota M.,

Biochem. J. 344:667-675(1999)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and comparative analysis of human chromosome 20

Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Rogers J.,

Nature 414:865-871(2001)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47

Hatherley D., Graham S.C., Turner J., Harlos K., Stuart D.I., Barclay A.N.,

Mol. Cell 31:266-277(2008)

Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells

Brooke G.P., Parsons K.R., Howard C.J.,

Eur. J. Immunol. 28:1-11(1998)

SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages

Timms J.F., Swanson K.D., Marie-Cardine A., Raab M., Rudd C.E., Schraven B., Neel B.G.,

Curr. Biol. 9:927-930(1999)

Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha

Stofega M.R., Argetsinger L.S., Wang H., Ullrich A., Carter-Su C.,

J. Biol. Chem. 275:28222-28229(2000)