SIRPɑ

Synonyms

SHPS-1, Macrophage fusion receptor, Brain Ig-like molecule with tyrosine-based activation motifs, MFR, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, CD172a, MyD-1 antigen, Sirp-alpha-3, MYD1, SIRPA, Signal Regulatory Protein Alpha, CD172 Antigen-Like Family Member A, Inhibitory Receptor SHPS-1, PTPNS1, SHPS1, SIRP, P84, Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs, Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1, Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, Tyrosine Phosphatase SHP Substrate 1, Signal-Regulatory Protein Alpha-3, Signal-Regulatory Protein Alpha, SHP Substrate 1, CD172a Antigen, Sirp-Alpha-1, Sirp-Alpha-2, MYD-1, Bit, SIRPalpha, SIRPalpha2

Description

NCBI Gene ID: 19261

KO Status

RenMab: Hits

RenLite: F1

Drug Information

Launched drugs: 2
Drugs in clinical trials: 7
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Elagolix/estradiol/norethindrone acetate

Approved

Abbvie Inc

Menorrhagia

GS-0189

FSI-189, GS-0189, FSI89

Gilead Sciences Inc

Relugolix/Estradiol/Norethindrone Acetate

Approved

Myovant Sciences

Pain, Endometriosis, Leiomyoma, Uterine Neoplasms, Menorrhagia

RRx-001

ABDNAZ, RRx-001

Phase 3 Clinical

Epicentre Biotechnologies Llc

Solid tumours, Glioblastoma, Small Cell Lung Carcinoma, Carcinoma, Ovarian Epithelial, Neoplasms, Oligodendroglioma, Neuroendocrine Tumors, Central Nervous System Neoplasms, Cholangiocarcinoma, Brain Neoplasms, Colorectal Neoplasms, Lymphoma, Carcinoma, Small Cell, Brain metastases, Neoplasm Metastasis, Carcinoma, Non-Small-Cell Lung, Stomatitis

CC-95251

CC-95251

Phase 1 Clinical

Celgene Corp

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

BR-105

BR105

Phase 1 Clinical

Hisun Biopharmaceutical Co Ltd, BioRay Pharmaceutical Co Ltd

Neoplasms

TQB-2928

TQB-2928

Phase 1 Clinical

Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd

Hematologic Neoplasms, Solid tumours, Neoplasms

[89Zr]Zr- BI-765063(Boehringer Ingelheim)

Phase 1 Clinical

Boehringer Ingelheim Corp

Squamous Cell Carcinoma of Head and Neck, Melanoma, Carcinoma, Non-Small-Cell Lung

AL-008

AL-008, IBI-397

Phase 1 Clinical

Alector

Neoplasms

BI-765063

OSE-172, BI-765063

Phase 1 Clinical

Ose Immunotherapeutics

Solid tumours, Squamous Cell Carcinoma of Head and Neck, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

References


Title

Authors

Source

Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes

Yamao T., Matozaki T., Amano K., Matsuda Y., Takahashi N., Ochi F., Fujioka Y., Kasuga M.,

Biochem. Biophys. Res. Commun. 231:61-67(1997)

A family of proteins that inhibit signalling through tyrosine kinase receptors

Kharitonenkov A., Chen Z., Sures I., Wang H., Schilling J., Ullrich A.,

Nature 386:181-186(1997)

Gene structure of mouse BIT/SHPS-1

Sano S., Ohnishi H., Kubota M.,

Biochem. J. 344:667-675(1999)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and comparative analysis of human chromosome 20

Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Rogers J.,

Nature 414:865-871(2001)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47

Hatherley D., Graham S.C., Turner J., Harlos K., Stuart D.I., Barclay A.N.,

Mol. Cell 31:266-277(2008)

Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells

Brooke G.P., Parsons K.R., Howard C.J.,

Eur. J. Immunol. 28:1-11(1998)

SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages

Timms J.F., Swanson K.D., Marie-Cardine A., Raab M., Rudd C.E., Schraven B., Neel B.G.,

Curr. Biol. 9:927-930(1999)

Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha

Stofega M.R., Argetsinger L.S., Wang H., Ullrich A., Carter-Su C.,

J. Biol. Chem. 275:28222-28229(2000)