TROP2

Synonyms

Trophoblast Cell Surface Antigen 2, Tumor-associated calcium signal transducer 2, M1S1, TROP2, TACSTD2, Pancreatic carcinoma marker protein GA733-1, Tumor Associated Calcium Signal Transducer 2, GA733-1, Membrane Component, Chromosome 1, Surface Marker 1, Gastrointestinal Tumor-Associated Antigen GA7331, Pancreatic Carcinoma Marker Protein GA7331, Cell Surface Glycoprotein TROP2, Epithelial Glycoprotein-1, Truncated TACSTD2, GA7331, EGP-1, EGP1, GP50, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, 40kD Glycoprotein, Identified By Monoclonal Antibody GA733

Description

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1),is a protein that in humans is encoded by the TACSTD2 gene.

KO Status

RenMab: Immunization

RenLite: F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 4
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Sacituzumab govitecan

IMMU-132, TROP-2-SN-38

Approved

Immunomedics Inc

Liver Failure, Solid tumours, Ovarian Neoplasms, Esophageal Neoplasms, Stomach Neoplasms, Carcinoma, Renal Cell, Squamous Cell Carcinoma of Head and Neck, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Carcinoma, Ovarian Epithelial, Glioblastoma, Pancreatic Neoplasms, Urinary Bladder Neoplasms, Prostatic Neoplasms, Breast Neoplasms, Metastatic breast cancer, Endometrial Neoplasms, Carcinoma, Hepatocellular, Uterine Cervical Neoplasms, Carcinoma, Non-Small-Cell Lung

datopotamab

DS-1062a, DS-1062, Dato-DXd

Phase 3 Clinical

Daiichi Sankyo Co Ltd

Triple Negative Breast Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung

SKB-264

SKB-264

Phase 2 Clinical

Sichuan Kelun Pharmaceutical Co Ltd

Solid tumours, Stomach Neoplasms, Carcinoma, Ovarian Epithelial, Small Cell Lung Carcinoma, Carcinoma, Transitional Cell, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung

DAC-002

DAC-002, JS-108

Phase 1 Clinical

Hangzhou Dac Biotech Co Ltd

Solid tumours, Triple Negative Breast Neoplasms

BAT8003

BAT-8003

Phase 1 Clinical

Bio-Thera Solutions Ltd

Solid tumours, Carcinoma, Transitional Cell

FDA018 Antibody Drug Conjugate

IND

Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd

Solid tumours

重组人源化抗Trop2单抗-SN38偶联物

IND

Neoplasms

LIV-2008

LIV-2008

Preclinical

LivTech Inc

Neoplasms

111In-IMP-288

111In-IMP-288, [111In]IMP-288

Pending

Immunomedics Inc

Neoplasms

References


Title

Authors

Source

Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733

Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H., Dietzschold B., Speicher D., Koprowski H.,

Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989)

Retroposition in a family of carcinoma-associated antigen genes

Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J., Druck T., Huebner K.,

Mol. Cell. Biol. 13:1507-1515(1993)

Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas

Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S.,

Int. J. Cancer 62:610-618(1995)

The DNA sequence and biological annotation of human chromosome 1

Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Bentley D.R.,

Nature 441:315-321(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Identification of the gene responsible for gelatinous drop-like corneal dystrophy

Tsujikawa M., Kurahashi H., Tanaka T., Nishida K., Shimomura Y., Tano Y., Nakamura Y.,

Nat. Genet. 21:420-423(1999)

Initial characterization of the human central proteome

Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.,

BMC Syst. Biol. 5:17-17(2011)

A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy

Tasa G., Kals J., Muru K., Juronen E., Piirsoo A., Veromann S., Janes S., Mikelsaar A.V., Lang A.,

Invest. Ophthalmol. Vis. Sci. 42:2762-2764(2001)