Search & Filter Knockouts

By Phase:

  • Autoimmunity & Inflammation

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • C1S

      Immunomodulator Target

    • F0
    • CRTH2/PTGDR2

      GPCR

    • F1 (+/-)
    • ELAM/ESEL/CD62E/ELAM1/LECAM2/SELE

      Cell Adhesion Molecules

    • F0
    • FcRn/FCGRT

      Immunomodulator Target

    • F0
    • IL-10RA

      Cytokine Receptor

    • F0
    • IL-17RA

      Cytokine Receptor

    • F1 (+/-)
    • IL-23R

      Cytokine Receptor

    • Exclusive Partnership
    • IL-36R/IL1RL2

      Cytokine Receptor

    • F0
    • IL-6RA

      Cytokine Receptor

    • F0
    • IL12B/CLMF/NKSF/CLMF2

      Cytokine

    • F0
    • IL13

      Cytokine

    • F0
    • IL17A/CTLA-8

      Cytokine

    • F0
    • IL17E/IL25

      Cytokine

    • F0
    • IL17F

      Cytokine

    • F0
    • IL18/IL-1g/ IL1F4/IGIF

      Cytokine

    • F0
    • IL21

      Cytokine

    • F0
    • IL21R/NILR/CD360

      Cytokine Receptor

    • F0
    • IL22RA1/CRF2-9/IL22R/IL22R1

      Cytokine Receptor

    • F0
    • IL23/IL-23A/IL23P19/P19

      Cytokine

    • F0
    • IL31RA

      Cytokine Receptor

    • F1 (+/-)
    • IL33

      Cytokine

    • F0
    • IL4

      Cytokine

    • F0
    • IL4RA/L4R

      Cytokine Receptor

    • F1 (+/-)
    • IL5R/CD125

      Cytokine Receptor

    • F0
    • LIGHT/CD258/ HVEML

      Cytokine

    • F0
    • OSM

      Cytokine

    • F0
    • SELPLG

      Immunomodulator Target

    • F0
    • ST2/IL1RL1/IL33R

      Cytokine Receptor

    • F0
  • Cardiovascular

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • CX3CR1/GPR13/CMKDR1

      GPCR

    • F0
  • Fibro-Inflammatory Disease/NASH/Diabetes

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • CB1

      GPCR

    • Immunization
    • GCGR

      GPCR

    • F2 (-/-)
    • GLP1R/GLP-1

      GPCR

    • F0
  • Infection, Autoimmunity & Inflammation

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • CKR5/CCR-5/CD195/CCCKR5/CCR5

      GPCR

    • F0
    • TGM2

      Enzyme

    • F0
    • TLR3/CD283/IIAE2

      Essential Signaling

    • F0
    • TNFRSF1A/TNFAR/TNFR1

      Cytokine Receptor

    • F0
  • Infectious, Autoimmunity & Inflammation

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • CD14

      Immunomodulator Target

    • F0
  • Oncology

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • 4-1BB/CD137/TNFRSF9

      Immunomodulator Target

    • F0
    • ABCB1/CD243/GP170

      Transporters

    • F0
    • ADAM9/MCMP

      Enzyme

    • F0
    • ALK/CD246/NBLST3

      Essential Signaling

    • F0
    • AMHR/MRII/MISR2/MISRII/AMHR2

      TAA

    • F0
    • ANTXR1/TEM8

      TAA

    • F0
    • AXL/UFO/ JTK11

      TAA

    • F0
    • B7-H3

      Immunomodulator Target

    • Exclusive Partnership
    • B7-H4/VTCN1

      Immunomodulator Target

    • F0
    • B7H5/PD-1H/ VISTA

      Immunomodulator Target

    • F0
    • BCMA/TNFRSF17/CD269

      TAA

    • F0
    • BTLA

      Immunomodulator Target

    • F0
    • CACNA2D1/CCHL2A

      Channels

    • F0
    • CAIX/CA9/G250

      TAA

    • F0
    • CCR4

      GPCR

    • F2 (-/-)
    • CCR7/CD197

      GPCR

    • F0
    • CCR8/ CKRL1/ CMKBR8

      GPCR

    • F0
    • CD226

      Immunomodulator Target

    • F0
    • CD24

      Immunomodulator Target

    • Exclusive Partnership
    • CD30/D1S166E/ Ki-1

      Cytokine Receptor

    • F0
    • CD33/SIGLEC-3

      TAA

    • F0
    • CD39/ENTPD1

      Immunomodulator Target

    • F0
    • CD40/TNFRSF5

      Immunomodulator Target

    • F0
    • CD40L/CD154/TNFSF5

      Immunomodulator Target

    • F0
    • CD44

      Immunomodulator Target

    • F0
    • CD47

      Immunomodulator Target

    • F1 (+/-)
    • CD61/GPIIIa/ITGB3

      TAA

    • F0
    • CD73

      Immunomodulator Target

    • F1 (+/-)
    • CD87/UPAR/URKR/U-PAR/PLAUR

      TAA

    • F0
    • CD96

      Immunomodulator Target

    • F0
    • CDH17/HPT1

      TAA

    • F0
    • CDH3/CDH15/CADH3

      TAA

    • F0
    • Claudin 18.2

      TAA

    • Immunization
    • CLL1/MICL/CD371/CLL-1/CLEC12A

      TAA

    • Exclusive Partnership
    • CXCR4

      GPCR

    • F0
    • DR5/CD262/TNFRSF10B/TRAILR2

      Immunomodulator Target

    • F0
    • FAP

      TAA

    • F0
    • FCGR3A/CD16A

      Immunomodulator Target

    • Exclusive Partnership
    • FGF2/BFGF/FGFB

      Cytokine

    • F0
    • FGF2/BFGF/FGFB

      Cytokine

    • F0
    • FGFR4/ JTK2/CD334

      Essential Signaling

    • F0
    • FGL-1

      Immunomodulator Target

    • F1 (+/-)
    • GITR

      Immunomodulator Target

    • F0
    • GPA33

      TAA

    • F0
    • GPC3/OCI-5/ SGBS1/ GTR2-2

      TAA

    • F0
    • GPR77/C5AR2

      GPCR

    • F0
    • GPRC5D

      GPCR

    • F0
    • ICOS/CD278

      Immunomodulator Target

    • F0
    • ITGB6/AI1H

      Essential Signaling

    • F0
    • KLRC1/NKG2A

      Immunomodulator Target

    • F0
    • L1CAM/SPG1/CAML1/CD171

      TAA

    • F0
    • LAG-3

      Immunomodulator Target

    • F1 (+/-)
    • LRRC15/LIB

      TAA

    • F0
    • MSLN/CAK1/MPF

      TAA

    • F0
    • MUC-16/CA-125

      TAA

    • F0
    • MUC1/CD227/EMA/H23AG

      Immunomodulator Target

    • F0
    • NKG2D/KLRK1

      Immunomodulator Target

    • F1 (+/-)
    • NKp46/NCR1

      Immunomodulator Target

    • F0
    • Notch3

      Essential Signaling

    • F0
    • OX40/CD134/TNFRSF4

      Immunomodulator Target

    • F0
    • PD-L1

      Immunomodulator Target

    • F1 (+/-)
    • PD-L2/B7DC/CD273/PDCD1LG2

      Immunomodulator Target

    • F0
    • PD1

      Immunomodulator Target

    • Immunization
    • SDC/ CD138/ SYND1

      TAA

    • F0
    • Siglec-10

      Immunomodulator Target

    • F1 (+/-)
    • Siglec-15

      Immunomodulator Target

    • Exclusive Partnership
    • SIGLEC15

      Immunomodulator Target

    • Exclusive Partnership
    • SIRPA

      Immunomodulator

    • F2 (-/-)
    • SLC7A11

      TAA

    • F1 (+/-)
    • STEAP/PRSS24/STEAP1

      TAA

    • F0
    • TIGIT/VSIG9/VSTM3

      Immunomodulator Target

    • F1 (+/-)
    • TIM3/CD366

      Immunomodulator Target

    • F0
    • TNFR2

      Immunomodulator Target

    • F2 (-/-)
    • TROP2/EGP1/GA733-1

      TAA

    • F0
  • Oncology & Cardiovascular

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • CD18/LFA-1/MAC-1

      Essential Signaling

    • F0
    • DDR1

      TAA

    • F0
  • Oncology, Autoimmunity & Inflammation

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • ALB

      Immunomodulator Target

    • F0
    • BLR1/CD185/MDR15/CXCR5

      GPCR

    • F0
    • C5A/C5AR/C5R1/CD88/C5AR1

      GPCR

    • F0
    • CB2/CNR2

      GPCR

    • F0
    • CCL2

      Cytokine

    • F0
    • CCR2

      GPCR

    • F0
    • CCR6/CD196/ CKR-L3/ CKRL3

      GPCR

    • F0
    • CD122

      Cytokine Receptor

    • F0
    • CD182/IL8R2/IL8RA/IL8RB/CXCR2

      GPCR

    • F0
    • CD2

      TAA

    • F0
    • CD20/CVID5/ LEU-16/ MS4A2

      TAA

    • F0
    • CD22/SIGLEC-2

      Immunomodulator Target

    • F0
    • CD26/ADABP/ADCP2

      Immunomodulator Target

    • F1 (+/-)
    • CD27/TNFRSF7/Tp55

      Cytokine Receptor

    • F0
    • CD27L/LPFS3/TNFSF7/CD70

      Immunomodulator Target

    • F0
    • CD45/B220/Ly-5

      Immunomodulator Target

    • F0
    • CD56

      Immunomodulator Target

    • F0
    • CD64

      Immunomodulator Target

    • F0
    • CD74/p33/ DHLAG/ HLADG

      Cytokine Receptor

    • F0
    • CD79b/AGM6/B29

      TAA

    • F0
    • FLT3/FLK2/ STK1/ CD135

      Cytokine Receptor

    • F0
    • FMS/CSFR/CD115/CSF-1R/CSF1R

      Cytokine Receptor

    • F0
    • GARP/LRRC32

      Immunomodulator Target

    • Exclusive Partnership
    • GM-CSF/CSF2

      Cytokine

    • F0
    • GPR9/MigR/CD182/CD183/CXCR3

      GPCR

    • F0
    • IL-10

      Cytokine

    • F0
    • IL-1ɑ

      Cytokine

    • F0
    • IL-1R1/IL1Rɑ/CD121ɑ

      Cytokine Receptor

    • F0
    • IL-1RAP/IL1RAP/IL1R3

      Cytokine Receptor

    • F1 (+/-)
    • IL-1β

      Cytokine

    • F0
    • IL-22/ILTIF/IL-TIF/IL-D110/IL22

      Cytokine

    • F0
    • IL-6/BSF-2/IFNB2/IFN-beta-2/IL6

      Cytokine

    • F0
    • IL15

      Cytokine

    • F0
    • IL18RA/CD218a

      Cytokine Receptor

    • F0
    • MDK/ARAP/NEGF2

      Essential Signaling

    • F0
    • MER/RP38/MERTK

      Immunomodulator Target

    • F0
    • MIF/GIF/ GLIF

      Cytokine

    • F0
    • p55/CD25/IL2R

      Cytokine Receptor

    • F0
    • PGF

      Growth Factor

    • F0
    • ROBO4/AOVD3/ECSM4

      Cytokine Receptor

    • F0
    • TSLP

      Cytokine

    • F0
  • Osteoporosis

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • SOST

      Cytokine

    • F1 (+/-)
  • Visual & Olfactory Diseases

    • Target
    • KO Mice Prep
    • Antibody Discovery
    • Efficacy Studies
    • CNGB1/GARP2

      Channels

    • F0