RenLite

RenLite™ Mouse: Empower Bispecific or Multispecific Antibody Development

Key Features

1. Complete human heavy chain variable domain combined with a common light chain substitution in situ

 

2. Fully human heavy chain antibody repertoire diversity

Heavy chain IGHV germline usage of naive RenLite™ mice

Heavy chain IGHV germline usage of naive RenLite™ mice

Heavy chain IGHD germline usage of naive RenLite™ mice

Heavy chain IGHJ germline usage of naive RenLite™ mice

3. Human-like CDR3 features

The median length of heavy chain CDR3 (14aa) from naive Renite™ mice is comparable to the average length of human CDR3.

Human-like CDR3 features, such as increasing frequency of tyrosine usage, are observed in RenLite™ mouse heavy chain CDR3.

 

4. Robust immune response comparable to wild type mouse

Validation Data

1. RenLite™ mouse shows similar immune cell profile as wild type mouse

2. RenLite™ mice show overall normal B cell development with slight delay compared to wild type mice.

3. Serum immunoglobulin Isotope & IgG Subtype Analysis

Serum concentrations of IgA, IgM and IgG subtypes of RenLite™ and wild type mice were measured by ELISA. Sera were equally diluted between two groups of mice.

Learn more: RenMab™/RenLite™ Technical Data Sheet

Download brochure