Biocytogen has developed a fully human antibody mouse (RenMab™ Mouse), whose genes that encode entire antibody variable regions are replace in situ by human Ig heavy chain and κ light chain through Mb-scale chromosome engineering technology. RenMab™ Mouse provides an efficient platform for fully human antibody generation, characterization, therapeutic antibody discovery, and rapid in vivo efficacy screening.
Highlights of RenMab™ Mouse:
- Developed using Biocytogen’s unique Mb-scale chromosome engineering technology
- Variable regions of mouse heavy chain and k light chain genes are replaced by human counterparts in situ
- Constant region is retained to ensure proper B cell development
- Normal immune organs development and good immune response to immunization like WT mouse
- RenMab antibodies exhibit human-like repertoire and high affinity to antigens in subnanomolar range
To Learn more, please fill out the form to download the brochure.