About the HiTS Platform

RenMice™ HiTS Platform

The RenMice™ HiTS (Hyperimmune Target Specific) Platform consists of a library of RenMice™ each with a specific target gene knocked out. These mice are designed to establish robust immune responses and generate antibodies that bind to more epitopes of the target protein, including conserved domains.

Applications of the RenMice™ HiTS Platform include:
• Antibody discovery against challenging targets, such as proteins with high homology between human and mouse, or GPCR/ion channel proteins.
• Surrogate antibody generation.
• Multiple epitope recognition from the same target protein.

Phase Overview of KO Targets Progress

231

F0

124

F1 (+/-)

59

F2 (-/-)

90

Immunization

134

Antibody Discovery

57

In Vitro

13

In Vivo

12

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