4-1BB

Synonyms

TNFRSF9, T-cell antigen ILA, ILA, T-Cell Antigen 4-1BB Homolog, 4-1BB Ligand Receptor, CD137 Antigen, CDw137, CD137, Tumor Necrosis Factor Receptor Superfamily, Member 9, Tumor Necrosis Factor Receptor Superfamily Member 9, Homolog Of Mouse 4-1BB, Receptor Protein 4-1BB, T Cell Antigen ILA, 4-1BB, TNF Receptor Superfamily Member 9, Interleukin-Activated Receptor, Homolog Of Mouse Ly63, Induced By Lymphocyte Activation (ILA)

Description

Tnfrsf9 (encoding CD137) is a candidate gene for the Idd9.3 type 1 diabetes (T1D) susceptibility locus in the nonobese diabetic (NOD) mouse model. CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA).

KO Status

RenLite: F2 (-/-)

Drug Information

Drugs in clinical trials: 17
Latest Research Phase: Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

QLF31907

QLF31907, QLF-31907

Qilu Pharmaceutical Co Ltd

ND-021

ND-021, NM21-1480, CS-2006, CS2006

Phase 2 Clinical

Numab Therapeutics Ag

Solid tumours, Neoplasms, Carcinoma, Non-Small-Cell Lung

GEN-1042

GEN-1042, BNT-312

Phase 2 Clinical

Genmab

Solid tumours, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma

Utomilumab

PF-2566, PF-5082566, PF-05082566

Phase 2 Clinical

Pfizer Pharmaceuticals Ltd (China)

Solid tumours, Ovarian Neoplasms, Lymphoma, B-Cell, Carcinoma, Renal Cell, Squamous Cell Carcinoma of Head and Neck, Lymphoma, Large B-Cell, Diffuse, Neoplasms, Breast Neoplasms, Lymphoma, Follicular, Colorectal Neoplasms, Oropharyngeal Neoplasms, Lymphoma, Non-Hodgkin, Carcinoma, Squamous Cell, Carcinoma, Non-Small-Cell Lung, Melanoma

Delolimogene mupadenorepvec

LOAd-703

Phase 2 Clinical

Lokon Pharma, Uppsala University

Biliary Tract Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Melanoma

Urelumab

BMS-66513, BMS-663513

Phase 2 Clinical

Bristol-Myers Squibb Company

Lymphoma, B-Cell, Head and Neck Neoplasms, Solid tumours, Neoplasms, Multiple Myeloma, Colorectal Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Carcinoma, Non-Small-Cell Lung, Leukemia, Lymphocytic, Chronic, B-Cell

EU-101

EU-101, NOV-1801

Phase 2 Clinical

Solid tumours, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung

GEN-1046

GEN1046, PD-L1x4-1BB, DuoBody-PD-L1x4-1BB

Phase 2 Clinical

Biontech Se, Genmab

Solid tumours, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Transitional Cell, Triple Negative Breast Neoplasms, Endometrial Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms

RO-7122290

RO-7122290

Phase 2 Clinical

F. Hoffmann-La Roche Ltd

Colorectal Neoplasms

ES101

ES101

Phase 2 Clinical

Inhibrx

Solid tumours, Thoracic Neoplasms, Small Cell Lung Carcinoma, Carcinoma, Non-Small-Cell Lung

References


Title

Authors

Source

The consensus coding sequences of human breast and colorectal cancers

Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Velculescu V.E.,

Science 314:268-274(2006)

A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction

Jang I.-K., Lee Z.-H., Kim H.-H., Hill J.M., Kim J.-D., Kwon B.S.,

Mol. Cells 12:304-312(2001)

Molecular and biological characterization of human 4-1BB and its ligand

Alderson M.R., Smith C.A., Tough T.W., Davis-Smith T., Armitage R.J., Falk B., Roux E., Baker E., Sutherland G.R., Din W.S., Goodwin R.G.,

Eur. J. Immunol. 24:2219-2227(1994)

A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family

Schwarz H., Tuckwell J., Lotz M.,

Gene 134:295-298(1993)

Characterization of human homologue of 4-1BB and its ligand

Zhou Z., Kim S., Hurtado J., Lee Z.H., Kim K.K., Pollok K.E., Kwon B.S.,

Immunol. Lett. 45:67-73(1995)

The DNA sequence and biological annotation of human chromosome 1

Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Bentley D.R.,

Nature 441:315-321(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Signal peptide prediction based on analysis of experimentally verified cleavage sites

Zhang Z., Henzel W.J.,

Protein Sci. 13:2819-2824(2004)

4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

Arch R.H., Thompson C.B.,

Mol. Cell. Biol. 18:558-565(1998)

CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand

Saoulli K., Lee S.Y., Cannons J.L., Yeh W.C., Santana A., Goldstein M.D., Bangia N., DeBenedette M.A., Mak T.W., Choi Y., Watts T.H.,

J. Exp. Med. 187:1849-1862(1998)