ADAMTS5

Synonyms

ADMP-2, ADAM-TS 11, ADAMTS-11, ADAMTS5, Aggrecanase-2, A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2), EC 3.4.24.14, ADAM-TS 5, ADAMTS-5, ADAMTS11, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5, EC 3.4.24.-, ADMP2, ADAMTS5 Protein, EC 3.4.24, EC:3.4.24.-, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11, EC 3.4.24.82, ADAM-TS5, ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5

Description

ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.

KO Status

F0

Drug Information

Drugs in clinical trials: 2
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

GLPG-1972

S-201086, GLPG-1972, GLPG-1972/S201086

Phase 2 Clinical

Galapagos Nv

Osteoarthritis

M-6495

ALX-1141, M-6495

Phase 1 Clinical

Ablynx, Merck Serono

Osteoarthritis, Knee, Osteoarthritis

CRB-0017

CRB-0017

Pending

Rottapharm

Osteoarthritis

References


Title

Authors

Source

Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan

Wang L.W., Leonhard-Melief C., Haltiwanger R.S., Apte S.S.,

J. Biol. Chem. 284:30004-30015(2009)

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Mosyak L., Georgiadis K., Shane T., Svenson K., Hebert T., McDonagh T., Mackie S., Olland S., Lin L., Zhong X., Kriz R., Reifenberg E.L., Collins-Racie L.A., Corcoran C., Freeman B., Zollner R., Marvell T., Vera M., Somers W.,

Protein Sci. 17:16-21(2008)

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

Abbaszade I., Liu R.-Q., Yang F., Rosenfeld S.A., Ross O.H., Link J.R., Ellis D.M., Tortorella M.D., Pratta M.A., Hollis J.M., Wynn R., Duke J.L., George H.J., Hillman M.C. Jr., Murphy K., Wiswall B.H., Copeland R.A., Decicco C.P., Burn T.C.,

J. Biol. Chem. 274:23443-23450(1999)

The DNA sequence of human chromosome 21

Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Yaspo M.-L.,

Nature 405:311-319(2000)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases

Hurskainen T.L., Hirohata S., Seldin M.F., Apte S.S.,

J. Biol. Chem. 274:25555-25563(1999)

Human glioblastomas overexpress ADAMTS-5 that degrades brevican

Nakada M., Miyamori H., Kita D., Takahashi T., Yamashita J., Sato H., Miura R., Yamaguchi Y., Okada Y.,

Acta Neuropathol. 110:239-246(2005)

Characterization of proADAMTS5 processing by proprotein convertases

Longpre J.M., McCulloch D.R., Koo B.H., Alexander J.P., Apte S.S., Leduc R.,

Int. J. Biochem. Cell Biol. 41:1116-1126(2009)

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.

Abbaszade I., Liu R.-Q., Yang F., Rosenfeld S.A., Ross O.H., Link J.R., Ellis D.M., Tortorella M.D., Pratta M.A., Hollis J.M., Wynn R., Duke J.L., George H.J., Hillman M.C. Jr., Murphy K., Wiswall B.H., Copeland R.A., Decicco C.P., Burn T.C.,

J. Biol. Chem. 274:23443-23450(1999)

The DNA sequence of human chromosome 21.

Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Yaspo M.-L.,

Nature 405:311-319(2000)