ADAMTS5

References

Title

Authors

Source

Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan

Wang L.W., Leonhard-Melief C., Haltiwanger R.S., Apte S.S.,

J. Biol. Chem. 284:30004-30015(2009)

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Mosyak L., Georgiadis K., Shane T., Svenson K., Hebert T., McDonagh T., Mackie S., Olland S., Lin L., Zhong X., Kriz R., Reifenberg E.L., Collins-Racie L.A., Corcoran C., Freeman B., Zollner R., Marvell T., Vera M., Somers W.,

Protein Sci. 17:16-21(2008)

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

Abbaszade I., Liu R.-Q., Yang F., Rosenfeld S.A., Ross O.H., Link J.R., Ellis D.M., Tortorella M.D., Pratta M.A., Hollis J.M., Wynn R., Duke J.L., George H.J., Hillman M.C. Jr., Murphy K., Wiswall B.H., Copeland R.A., Decicco C.P., Burn T.C.,

J. Biol. Chem. 274:23443-23450(1999)

The DNA sequence of human chromosome 21

Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Yaspo M.-L.,

Nature 405:311-319(2000)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases

Hurskainen T.L., Hirohata S., Seldin M.F., Apte S.S.,

J. Biol. Chem. 274:25555-25563(1999)

Human glioblastomas overexpress ADAMTS-5 that degrades brevican

Nakada M., Miyamori H., Kita D., Takahashi T., Yamashita J., Sato H., Miura R., Yamaguchi Y., Okada Y.,

Acta Neuropathol. 110:239-246(2005)

Characterization of proADAMTS5 processing by proprotein convertases

Longpre J.M., McCulloch D.R., Koo B.H., Alexander J.P., Apte S.S., Leduc R.,

Int. J. Biochem. Cell Biol. 41:1116-1126(2009)

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.

Abbaszade I., Liu R.-Q., Yang F., Rosenfeld S.A., Ross O.H., Link J.R., Ellis D.M., Tortorella M.D., Pratta M.A., Hollis J.M., Wynn R., Duke J.L., George H.J., Hillman M.C. Jr., Murphy K., Wiswall B.H., Copeland R.A., Decicco C.P., Burn T.C.,

J. Biol. Chem. 274:23443-23450(1999)

The DNA sequence of human chromosome 21.

Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Yaspo M.-L.,

Nature 405:311-319(2000)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases.

Hurskainen T.L., Hirohata S., Seldin M.F., Apte S.S.,

J. Biol. Chem. 274:25555-25563(1999)

Human glioblastomas overexpress ADAMTS-5 that degrades brevican.

Nakada M., Miyamori H., Kita D., Takahashi T., Yamashita J., Sato H., Miura R., Yamaguchi Y., Okada Y.,

Acta Neuropathol. 110:239-246(2005)

Characterization of proADAMTS5 processing by proprotein convertases.

Longpre J.M., McCulloch D.R., Koo B.H., Alexander J.P., Apte S.S., Leduc R.,

Int. J. Biochem. Cell Biol. 41:1116-1126(2009)

Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan.

Wang L.W., Leonhard-Melief C., Haltiwanger R.S., Apte S.S.,

J. Biol. Chem. 284:30004-30015(2009)

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.

Mosyak L., Georgiadis K., Shane T., Svenson K., Hebert T., McDonagh T., Mackie S., Olland S., Lin L., Zhong X., Kriz R., Reifenberg E.L., Collins-Racie L.A., Corcoran C., Freeman B., Zollner R., Marvell T., Vera M., Somers W.,

Protein Sci. 17:16-21(2008)

Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.

Nakamura H., Fujii Y., Inoki I., Sugimoto K., Tanzawa K., Matsuki H., Miura R., Yamaguchi Y., Okada Y.,

J Biol Chem 275:38885-38890(2000)

C-mannosylation and O-fucosylation of the thrombospondin type 1 module.

Hofsteenge J., Huwiler K.G., Macek B., Hess D., Lawler J., Mosher D.F., Peter-Katalinic J.,

J. Biol. Chem. 276:6485-6498(2001)

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

Yamanishi Y., Boyle D.L., Clark M., Maki R.A., Tortorella M.D., Arner E.C., Firestein G.S.,

J Immunol 168:1405-1412(2002)

[ADAMTS family--new extracellular matrix degrading enzyme].

Hirohata S.,

Seikagaku 73:1333-1337(2001)

Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.

Malfait A.M., Liu R.Q., Ijiri K., Komiya S., Tortorella M.D.,

J Biol Chem 277:22201-22208(2002)

ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.

Rodriguez-Manzaneque J.C., Westling J., Thai S.N., Luque A., Knauper V., Murphy G., Sandy J.D., Iruela-Arispe M.L.,

Biochem Biophys Res Commun 293:501-508(2002)

Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).

Tortorella M.D., Liu R.Q., Burn T., Newton R.C., Arner E.,

Matrix Biol 21:499-511(2002)

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.

Somerville R.P., Longpre J.-M., Jungers K.A., Engle J.M., Ross M., Evanko S., Wight T.N., Leduc R., Apte S.S.,

J. Biol. Chem. 278:9503-9513(2003)

Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.

Tortorella M.D., Arner E.C., Hills R., Easton A., Korte-Sarfaty J., Fok K., Wittwer A.J., Liu R.Q., Malfait A.M.,

J Biol Chem 279:17554-17561(2004)

ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.

Collins-Racie L.A., Flannery C.R., Zeng W., Corcoran C., Annis-Freeman B., Agostino M.J., Arai M., DiBlasio-Smith E., Dorner A.J., Georgiadis K.E., Jin M., Tan X.Y., Morris E.A., LaVallie E.R.,

Matrix Biol 23:219-230(2004)

The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.

Cross N.A., Chandrasekharan S., Jokonya N., Fowles A., Hamdy F.C., Buttle D.J., Eaton C.L.,

Prostate 63:269-275(2005)

Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.

Held-Feindt J., Paredes E.B., Blomer U., Seidenbecher C., Stark A.M., Mehdorn H.M., Mentlein R.,

Int J Cancer 118:55-61(2006)

Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats.

Luo Y., Nita-Lazar A., Haltiwanger R.S.,

J. Biol. Chem. 281:9385-9392(2006)

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.

Zeng W., Corcoran C., Collins-Racie L.A., Lavallie E.R., Morris E.A., Flannery C.R.,

Biochim Biophys Acta 1760:517-524(2006)

Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines.

Zhu H., Leung P.C., MacCalman C.D.,

Hum Reprod 22:63-74(2007)

Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter.

Thirunavukkarasu K., Pei Y., Wei T.,

Mol Biol Rep 34:225-231(2007)

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

Song R.H., Tortorella M.D., Malfait A.M., Alston J.T., Yang Z., Arner E.C., Griggs D.W.,

Arthritis Rheum 56:575-585(2007)

Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity.

Grogan S.P., Barbero A., Diaz-Romero J., Cleton-Jansen A.M., Soeder S., Whiteside R., Hogendoorn P.C., Farhadi J., Aigner T., Martin I., Mainil-Varlet P.,

Arthritis Rheum 56:586-595(2007)

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

Gendron C., Kashiwagi M., Lim N.H., Enghild J.J., Thogersen I.B., Hughes C., Caterson B., Nagase H.,

J Biol Chem 282:18294-18306(2007)

Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration.

Patel K.P., Sandy J.D., Akeda K., Miyamoto K., Chujo T., An H.S., Masuda K.,

Spine (Phila Pa 1976) 32:2596-2603(2007)

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).

Shieh H.S., Mathis K.J., Williams J.M., Hills R.L., Wiese J.F., Benson T.E., Kiefer J.R., Marino M.H., Carroll J.N., Leone J.W., Malfait A.M., Arner E.C., Tortorella M.D., Tomasselli A.,

J Biol Chem 283:1501-1507(2008)

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.

Fushimi K., Troeberg L., Nakamura H., Lim N.H., Nagase H.,

J Biol Chem 283:6706-6716(2008)

Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis.

Rodriguez-Lopez J., Mustafa Z., Pombo-Suarez M., Malizos K.N., Rego I., Blanco F.J., Tsezou A., Loughlin J., Gomez-Reino J.J., Gonzalez A.,

Arthritis Rheum 58:435-441(2008)

A transcriptional enhancer from the coding region of ADAMTS5.

Barthel K.K., Liu X.,

PLoS One 3:e2184-e2184(2008)

Proprotein convertase activation of aggrecanases in cartilage in situ.

Malfait A.M., Arner E.C., Song R.H., Alston J.T., Markosyan S., Staten N., Yang Z., Griggs D.W., Tortorella M.D.,

Arch Biochem Biophys 478:43-51(2008)

Peters'-plus syndrome is a congenital disorder of glycosylation caused by a defect in the beta1,3-glucosyltransferase that modifies thrombospondin type 1 repeats.

Heinonen T.Y., Maki M.,

Ann Med 41:2-10(2009)

Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.

Tortorella M.D., Tomasselli A.G., Mathis K.J., Schnute M.E., Woodard S.S., Munie G., Williams J.M., Caspers N., Wittwer A.J., Malfait A.M., Shieh H.S.,

J Biol Chem 284:24185-24191(2009)

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.

Troeberg L., Fushimi K., Scilabra S.D., Nakamura H., Dive V., Thogersen I.B., Enghild J.J., Nagase H.,

Matrix Biol 28:463-469(2009)

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.

Echtermeyer F., Bertrand J., Dreier R., Meinecke I., Neugebauer K., Fuerst M., Lee Y.J., Song Y.W., Herzog C., Theilmeier G., Pap T.,

Nat Med 15:1072-1076(2009)

Novel B3GALTL mutation in Peters-plus Syndrome.

Dassie-Ajdid J., Causse A., Poidvin A., Granier M., Kaplan J., Burglen L., Doummar D., Teisseire P., Vigouroux A., Malecaze F., Calvas P., Chassaing N.,

Clin Genet 76:490-492(2009)

Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.

Wheeler H.E., Metter E.J., Tanaka T., Absher D., Higgins J., Zahn J.M., Wilhelmy J., Davis R.W., Singleton A., Myers R.M., Ferrucci L., Kim S.K.,

PLoS Genet 5:e1000685-e1000685(2009)

Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system.

Zintzaras E., Kitsios G.D., Ziogas D.C., Rodopoulou P., Karachalios T.,

Am J Epidemiol 171:851-858(2010)

Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.

Warnatz H.J., Querfurth R., Guerasimova A., Cheng X., Haas S.A., Hufton A.L., Manke T., Vanhecke D., Nietfeld W., Vingron M., Janitz M., Lehrach H., Yaspo M.L.,

Nucleic Acids Res 38:6112-6123(2010)

Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture.

Coughlan T.C., Crawford A., Goldring M.B., Hatton P.V., Barker M.D.,

J Tissue Eng Regen Med 4:611-618(2010)

The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis.

Dyer M.D., Neff C., Dufford M., Rivera C.G., Shattuck D., Bassaganya-Riera J., Murali T.M., Sobral B.W.,

PLoS One 5:e12089-e12089(2010)

Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina.

Lee C.W., Hwang I., Park C.S., Lee H., Park D.W., Kang S.J., Lee S.H., Kim Y.H., Park S.W., Park S.J.,

J Clin Pathol 64:399-404(2011)

Structure analysis reveals the flexibility of the ADAMTS-5 active site.

Shieh H.S., Tomasselli A.G., Mathis K.J., Schnute M.E., Woodard S.S., Caspers N., Williams J.M., Kiefer J.R., Munie G., Wittwer A., Malfait A.M., Tortorella M.D.,

Protein Sci 20:735-744(2011)

ADAMTS-5 and intervertebral disc degeneration: the results of tissue immunohistochemistry and in vitro cell culture.

Zhao C.Q., Zhang Y.H., Jiang S.D., Li H., Jiang L.S., Dai L.Y.,

J Orthop Res 29:718-725(2011)

Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis.

Hattori N., Carrino D.A., Lauer M.E., Vasanji A., Wylie J.D., Nelson C.M., Apte S.S.,

J Biol Chem 286:34298-34310(2011)

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.

Lo Cicero A., Majkowska I., Nagase H., Di Liegro I., Troeberg L.,

Matrix Biol 31:229-233(2012)

Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis.

Didangelos A., Mayr U., Monaco C., Mayr M.,

J Biol Chem 287:19341-19345(2012)

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells.

Boeuf S., Graf F., Fischer J., Moradi B., Little C.B., Richter W.,

Eur Cell Mater 23:320-332(2012)

Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation.

Chen C.I., Keusch J.J., Klein D., Hess D., Hofsteenge J., Gut H.,

EMBO J. 31:3183-3197(2012)

Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases.

Gao W., Zhu J., Westfield L.A., Tuley E.A., Anderson P.J., Sadler J.E.,

J Biol Chem 287:26944-26952(2012)

Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines.

Turner S.L., Mangnall D., Bird N.C., Bunning R.A., Blair-Zajdel M.E.,

Int J Oncol 41:1043-1049(2012)

ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity.

Kumar S., Sharghi-Namini S., Rao N., Ge R.,

Am J Pathol 181:1056-1068(2012)

Association of ADAMTS5 gene polymorphisms with osteoarthritis in Chinese Han population: a community-based case-control study.

Gu J., Rong J., Guan F., Jiang L., Zhang T., Tao S., Guan G., Xu L., Tao T.,

Rheumatol Int 33:2893-2897(2013)

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

Yamamoto K., Troeberg L., Scilabra S.D., Pelosi M., Murphy C.L., Strickland D.K., Nagase H.,

FASEB J 27:511-521(2013)

Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators.

Krstic D., Rodriguez M., Knuesel I.,

PLoS One 7:e47793-e47793(2012)

Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.

Filou S., Stylianou M., Triantaphyllidou I.E., Papadas T., Mastronikolis N.S., Goumas P.D., Papachristou D.J., Ravazoula P., Skandalis S.S., Vynios D.H.,

Biochimie 95:725-734(2013)

ADAMTS: novel proteases expressed by activated mast cells.

Garcia-Faroldi G., Ronnberg E., Orro A., Calounova G., Guss B., Lundequist A., Pejler G.,

Biol Chem 394:291-305(2013)

Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.

El Khoury L., Posthumus M., Collins M., Handley C.J., Cook J., Raleigh S.M.,

J Sci Med Sport 16:493-498(2013)

Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17.

Ashlin T.G., Kwan A.P., Ramji D.P.,

Cytokine 64:234-242(2013)

Novel B3GALTL mutations in classic Peters plus syndrome and lack of mutations in a large cohort of patients with similar phenotypes.

Weh E., Reis L.M., Tyler R.C., Bick D., Rhead W.J., Wallace S., McGregor T.L., Dills S.K., Chao M.C., Murray J.C., Semina E.V.,

Clin Genet 86:142-148(2014)

Transcriptional induction of ADAMTS5 protein by nuclear factor-kappaB (NF-kappaB) family member RelA/p65 in chondrocytes during osteoarthritis development.

Kobayashi H., Hirata M., Saito T., Itoh S., Chung U.I., Kawaguchi H.,

J Biol Chem 288:28620-28629(2013)

PKCepsilon signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells.

Tsirimonaki E., Fedonidis C., Pneumaticos S.G., Tragas A.A., Michalopoulos I., Mangoura D.,

PLoS One 8:e82045-e82045(2013)

The involvement of ADAMTS-5 genetic polymorphisms in predisposition and diffusion tensor imaging alterations of lumbar disc degeneration.

Wu N., Chen J., Liu H., Zhao L., Liu S., Liu J., Su X., Wu W., Cong J., Qiu G., Wu Z.,

J Orthop Res 32:686-694(2014)

Upregulation of tumor necrosis factor alpha and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes.

Chen S., Huang Y., Zhou Z.J., Hu Z.J., Wang J.Y., Xu W.B., Fang X.Q., Fan S.W.,

Spine (Phila Pa 1976) 39:E817-25(2014)

Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases.

Lee S.Y., Lee H.S., Gil M., Kim C.J., Lee Y.H., Kim K.R., Park C.S.,

Arch Pathol Lab Med 138:643-650(2014)

Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5.

Foulcer S.J., Nelson C.M., Quintero M.V., Kuberan B., Larkin J., Dours-Zimmermann M.T., Zimmermann D.R., Apte S.S.,

J Biol Chem 289:27859-27873(2014)

ADAMTS-4 and ADAMTS-5 expression in human temporomandibular joint discs with internal derangement, correlates with degeneration.

Leonardi R., Crimi S., Almeida L.E., Pannone G., Musumeci G., Castorina S., Rusu M.C., Loreto C.,

J Oral Pathol Med 44:870-875(2015)

Association Between a Variant in ADAMTS5 and the Susceptibility to Hepatocellular Carcinoma in a Chinese Han Population.

Li C., Xiong Y., Zhong Z., Zhang S., Peng Y., Wang L., Dai N., Li M., Ren T., Gan L., Wang D.,

Cell Biochem Biophys 72:221-225(2015)

Peters plus syndrome mutations disrupt a noncanonical ER quality-control mechanism.

Vasudevan D., Takeuchi H., Johar S.S., Majerus E., Haltiwanger R.S.,

Curr Biol 25:286-295(2015)

Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma.

Li C., Xiong Y., Yang X., Wang L., Zhang S., Dai N., Li M., Ren T., Yang Y., Zhou S.F., Gan L., Wang D.,

Drug Des Devel Ther 9:1773-1783(2015)

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).

Santamaria S., Yamamoto K., Botkjaer K., Tape C., Dyson M.R., McCafferty J., Murphy G., Nagase H.,

Biochem J 471:391-401(2015)

Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).

Shiraishi A., Mochizuki S., Miyakoshi A., Kojoh K., Okada Y.,

Biochem Biophys Res Commun 469:62-69(2016)

A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers.

Kosasih H.J., Last K., Rogerson F.M., Golub S.B., Gauci S.J., Russo V.C., Stanton H., Wilson R., Lamande S.R., Holden P., Fosang A.J.,

J Biol Chem 291:3197-3208(2016)

Hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes.

Lu X., Lin J., Jin J., Qian W., Weng X.,

Int J Mol Med 37:509-516(2016)

Overexpression of ADAMTS5 can regulate the migration and invasion of non-small cell lung cancer.

Gu J., Chen J., Feng J., Liu Y., Xue Q., Mao G., Gai L., Lu X., Zhang R., Cheng J., Hu Y., Shao M., Shen H., Huang J.,

Tumour Biol 37:8681-8689(2016)

Role of ADAMTS1 and ADAMTS5 in male infertility.

Aydos S.E., Yukselten Y., Sunguroglu A., Demircan K., Aydos K.,

Andrologia 48:1113-1119(2016)

The IL-1beta/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis.

Ji Q., Xu X., Zhang Q., Kang L., Xu Y., Zhang K., Li L., Liang Y., Hong T., Ye Q., Wang Y.,

J Mol Med (Berl) 94:771-785(2016)

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.

Yamamoto K., Okano H., Miyagawa W., Visse R., Shitomi Y., Santamaria S., Dudhia J., Troeberg L., Strickland D.K., Hirohata S., Nagase H.,

Matrix Biol 56:57-73(2016)

Role of ADAMTS5 in Unexplained Fetal Growth Restriction (FGR).

Ozler S., Oztas E., Guler B.G., Pehlivan S., Kadioglu N., Ergin M., Uygur D., Danisman N.,

Fetal Pediatr Pathol 35:220-230(2016)

Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.

Canbek U., Imerci A., Kara M., Akgun U., Canbek T.D., Aydogan N.H.,

Genet Mol Res 15:0-0(2016)

microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5.

Yu L., Lu Y., Han X., Zhao W., Li J., Mao J., Wang B., Shen J., Fan S., Wang L., Wang M., Li L., Tang J., Song B.,

Stem Cell Res Ther 7:180-180(2016)

Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes.

Perera R.S., Dissanayake P.H., Senarath U., Wijayaratne L.S., Karunanayake A.L., Dissanayake V.H.,

PLoS One 12:e0169835-e0169835(2017)

Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/beta-Catenin Pathway.

Cheleschi S., De Palma A., Pecorelli A., Pascarelli N.A., Valacchi G., Belmonte G., Carta S., Galeazzi M., Fioravanti A.,

Int J Mol Sci 18:0-0(2017)

Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.

Fontanil T., Alvarez-Teijeiro S., Villaronga M.A., Mohamedi Y., Solares L., Moncada-Pazos A., Vega J.A., Garcia-Suarez O., Perez-Basterrechea M., Garcia-Pedrero J.M., Obaya A.J., Cal S.,

Oncotarget 8:13716-13729(2017)

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.

Santamaria S., Fedorov O., McCafferty J., Murphy G., Dudhia J., Nagase H., Yamamoto K.,

MAbs 9:595-602(2017)

The noncoding RNA linc-ADAMTS5 cooperates with RREB1 to protect from intervertebral disc degeneration through inhibiting ADAMTS5 expression.

Wang K., Song Y., Liu W., Wu X., Zhang Y., Li S., Kang L., Tu J., Zhao K., Hua W., Yang C.,

Clin Sci (Lond) 131:965-979(2017)

ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells.

Li F., Song R., Ao L., Reece T.B., Cleveland J.C. Jr., Dong N., Fullerton D.A., Meng X.,

Arterioscler Thromb Vasc Biol 37:1339-1351(2017)

Association between COL11A1 (rs1337185) and ADAMTS5 (rs162509) gene polymorphisms and lumbar spine pathologies in Chinese Han population: an observational study.

Jiang H., Yang Q., Jiang J., Zhan X., Xiao Z.,

BMJ Open 7:e015644-e015644(2017)

Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritis chondrocytes.

Liu Y., Zhu H., Yan X., Gu H., Gu Z., Liu F.,

Biochem Biophys Res Commun 491:368-373(2017)

Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage.

Tajima T., Sekimoto T., Yamaguchi N., Taniguchi N., Kurogi S., Maruyama M., Chosa E.,

BMC Musculoskelet Disord 18:449-449(2017)

Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.

Li J., Liao Y., Huang J., Sun Y., Chen H., Chen C., Li S., Yang Z.,

J Cancer Res Clin Oncol 144:215-227(2018)

Targeted next-generation sequencing identified ADAMTS5 as novel genetic substrate in patients with bicuspid aortic valve.

Lin X., Liu X., Wang L., Jiang J., Sun Y., Zhu Q., Chen Z., He Y., Hu P., Xu Q., Gao F., Lin Y., Jaiswal S., Xiang M., Wang J.,

Int J Cardiol 252:150-155(2018)

Association of ADAMTS4 and ADAMTS5 polymorphisms with musculoskeletal degenerative diseases: a systematic review and meta-analysis.

Huo J.Z., Ji X.H., Su Z.Y., Shang P., Gao F.,

Biosci Rep 38:0-0(2018)

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis.

Zhou X., Jiang L., Zhang Y., Zhang J., Zhou D., Wu L., Huang Y., Xu N.,

Braz J Med Biol Res 52:e8109-e8109(2019)

Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-alpha and spontaneous preterm delivery in singleton pregnancies.

Melekoglu R., Yilmaz E., Ciftci O., Kafadar Y.T., Celik E.,

J Perinat Med 47:304-310(2019)

Matrix-degrading protease ADAMTS-5 cleaves inter-alpha-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients.

Scavenius C., Poulsen E.C., Thogersen I.B., Roebuck M., Frostick S., Bou-Gharios G., Yamamoto K., Deleuran B., Enghild J.J.,

J Biol Chem 294:15495-15504(2019)

LncRNA MALAT1/MiR-145 Adjusts IL-1beta-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis.

Liu C., Ren S., Zhao S., Wang Y.,

Yonsei Med J 60:1081-1092(2019)

ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease.

Wang Z., Ye D., Ye J., Wang M., Liu J., Jiang H., Xu Y., Zhang J., Chen J., Wan J.,

Dis Markers 2019:6129748-6129748(2019)

Synonyms

Description

KO Status

Drug Information

GLPG-1972

M-6495

CRB-0017