ADIPOR1

Synonyms

ACDCR1, Adiponectin Receptor 1, TESBP1A, CGI-45, Progestin And AdipoQ Receptor Family Member 1, Adiponectin Receptor Protein 1, CGI45, Progestin And AdipoQ Receptor Family Member I, ADIPOR1, PAQR1,

Description

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism . Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin.

KO Status

F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 0
Latest Research Phase:Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

ALY-688

ALY-688, ADP-355, ALY-732

Phase 2 Clinical

Allysta Pharmaceuticals

Dry Eye Syndromes, Xerophthalmia