ADIPOR1
Synonyms
ACDCR1, Adiponectin Receptor 1, TESBP1A, CGI-45, Progestin And AdipoQ Receptor Family Member 1, Adiponectin Receptor Protein 1, CGI45, Progestin And AdipoQ Receptor Family Member I, ADIPOR1, PAQR1,Description
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism . Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin.
KO Status
F0
Drug Information
Launched drugs: 0
Drug in clinical trials: 1
Latest Research Phase:Phase 2 Clinical
Drug Name
Code
Phase
Company
Indications
Clinical Trials
ALY-688
ALY-688, ADP-355, ALY-732
Phase 2 Clinical
Allysta Pharmaceuticals
Dry Eye Syndromes, Xerophthalmia