AGTR1

Synonyms

AT1BR, AT2R1B, AT1, AGTR1B, AGTR1, Angiotensin II Receptor Type 1, AT1AR, AT2R1, Type-1B Angiotensin II Receptor, Type-1 Angiotensin II Receptor, Angiotensin II Type-1 Receptor, Angiotensin Receptor 1B, AGTR1A, HAT1R, AG2S, AT1B, AT1R, Receptor, Angiotensin, Type 1, AT2R1A

KO Status

RenMab: F0

Drug Information

Launched drugs: 51
Drugs in clinical trials: 30
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Azilsartan

TAK-536

Approved

Takeda Pharmaceutical Co Ltd

Diabetes Mellitus, Type 2, Hypertension, Essential Hypertension

Hydrobentizide/Olmesartan Medoxomil

Approved

Aurobindo Pharma (Portugal), Unipessoal Limitada

Essential Hypertension

Atorvastatin Calcium Hydrate/Irbesartan

HCP-0912

Approved

Hanmi Pharmaceutical Co Ltd

Hypertension, Hyperlipidemias

Amlodipine Besylate/Telmisartan

Approved

C.H. Boehringer Sohn Ag & Co. Kg

Hypertension

Rosuvastatin Calcium/Telmisartan

YMC-017, YH-16410

Approved

Yuhan Corp

Hypertension, Hyperlipidemias

Losartan Potassium

E-3340, MK-954, DuP-753, MK-0954, HGP-0608, L-158086, Ex-89 (free acid)

Approved

Merck Sharp & Dohme Corp

Drug-Related Side Effects and Adverse Reactions, Heart Failure, Diabetes Mellitus, Type 2, Kidney Diseases, Hypertension, Hypertrophy, Left Ventricular, Diabetic Nephropathies

Olmesartan Medoxomil/Amlodipine Besylate/Hydrochlorothiazide

CS-8635

Approved

Daiichi Sankyo Co Ltd

Hypertension, Essential Hypertension

Amlodipine Besylate/Fimasartan Potassium

Approved

Boryung Pharmaceutical Co Ltd

Essential Hypertension

Levamlodipine Besylate/Valsartan

Approved

Ahn-Gook Pharmaceuticals

Hypertension

Hydrochlorothiazide/Losartan Potassium

MK-954H, MK-0954A, MK-0954H

Approved

Merck Sharp & Dohme Corp

Hypertension

References


Title

Authors

Source

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

Kostenis E., Milligan G., Christopoulos A., Sanchez-Ferrer C.F., Heringer-Walther S., Sexton P.M., Gembardt F., Kellett E., Martini L., Vanderheyden P., Schultheiss H.P., Walther T.,

Circulation 111:1806-1813(2005)

A strategy for precise and large scale identification of core fucosylated glycoproteins

Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.,

Mol. Cell. Proteomics 8:913-923(2009)

G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation

Tirupula K.C., Ithychanda S.S., Mohan M.L., Naga Prasad S.V., Qin J., Karnik S.S.,

Biochemistry 54:6673-6683(2015)

Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis

Gribouval O., Gonzales M., Neuhaus T., Aziza J., Bieth E., Laurent N., Bouton J.M., Feuillet F., Makni S., Ben Amar H., Laube G., Delezoide A.-L., Bouvier R., Dijoud F., Ollagnon-Roman E., Roume J., Joubert M., Antignac C., Gubler M.-C.,

Nat. Genet. 37:964-968(2005)

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.,

Biochem. Biophys. Res. Commun. 186:277-284(1992)

Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor

Furuta H., Guo D.F., Inagami T.,

Biochem. Biophys. Res. Commun. 183:8-13(1992)

Cloning and characterization of a human angiotensin II type 1 receptor

Bergsma D.J., Ellis C., Kumar C., Nuthalaganti P., Kersten H., Elshourbagy N.A., Griffin E., Stadel J.M., Aiyar N.,

Biochem. Biophys. Res. Commun. 183:989-995(1992)

Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor

Takayanagi R., Ohnaka K., Sakai Y., Nakao R., Yanase T., Haji M., Inagami T., Furuta H., Gou D.F., Nakamuta M., Nawata H.,

Biochem. Biophys. Res. Commun. 183:910-916(1992)

Genetic analysis of the human type-1 angiotensin II receptor

Curnow K.M., Pascoe L., White P.C.,

Mol. Endocrinol. 6:1113-1118(1992)