AT1BR, AT2R1B, AT1, AGTR1B, AGTR1, Angiotensin II Receptor Type 1, AT1AR, AT2R1, Type-1B Angiotensin II Receptor, Type-1 Angiotensin II Receptor, Angiotensin II Type-1 Receptor, Angiotensin Receptor 1B, AGTR1A, HAT1R, AG2S, AT1B, AT1R, Receptor, Angiotensin, Type 1, AT2R1A

KO Status

RenMab: F0

Drug Information

Launched drugs: 51
Drugs in clinical trials: 30
Latest Research Phase: Approved

Drug Name





Clinical Trials




Takeda Pharmaceutical Co Ltd

Diabetes Mellitus, Type 2, Hypertension, Essential Hypertension

Hydrobentizide/Olmesartan Medoxomil


Aurobindo Pharma (Portugal), Unipessoal Limitada

Essential Hypertension

Atorvastatin Calcium Hydrate/Irbesartan



Hanmi Pharmaceutical Co Ltd

Hypertension, Hyperlipidemias

Amlodipine Besylate/Telmisartan


C.H. Boehringer Sohn Ag & Co. Kg


Rosuvastatin Calcium/Telmisartan

YMC-017, YH-16410


Yuhan Corp

Hypertension, Hyperlipidemias

Losartan Potassium

E-3340, MK-954, DuP-753, MK-0954, HGP-0608, L-158086, Ex-89 (free acid)


Merck Sharp & Dohme Corp

Drug-Related Side Effects and Adverse Reactions, Heart Failure, Diabetes Mellitus, Type 2, Kidney Diseases, Hypertension, Hypertrophy, Left Ventricular, Diabetic Nephropathies

Olmesartan Medoxomil/Amlodipine Besylate/Hydrochlorothiazide



Daiichi Sankyo Co Ltd

Hypertension, Essential Hypertension

Amlodipine Besylate/Fimasartan Potassium


Boryung Pharmaceutical Co Ltd

Essential Hypertension

Levamlodipine Besylate/Valsartan


Ahn-Gook Pharmaceuticals


Hydrochlorothiazide/Losartan Potassium

MK-954H, MK-0954A, MK-0954H


Merck Sharp & Dohme Corp






The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

Kostenis E., Milligan G., Christopoulos A., Sanchez-Ferrer C.F., Heringer-Walther S., Sexton P.M., Gembardt F., Kellett E., Martini L., Vanderheyden P., Schultheiss H.P., Walther T.,

Circulation 111:1806-1813(2005)

A strategy for precise and large scale identification of core fucosylated glycoproteins

Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.,

Mol. Cell. Proteomics 8:913-923(2009)

G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation

Tirupula K.C., Ithychanda S.S., Mohan M.L., Naga Prasad S.V., Qin J., Karnik S.S.,

Biochemistry 54:6673-6683(2015)

Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis

Gribouval O., Gonzales M., Neuhaus T., Aziza J., Bieth E., Laurent N., Bouton J.M., Feuillet F., Makni S., Ben Amar H., Laube G., Delezoide A.-L., Bouvier R., Dijoud F., Ollagnon-Roman E., Roume J., Joubert M., Antignac C., Gubler M.-C.,

Nat. Genet. 37:964-968(2005)

Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor

Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.,

Biochem. Biophys. Res. Commun. 186:277-284(1992)

Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor

Furuta H., Guo D.F., Inagami T.,

Biochem. Biophys. Res. Commun. 183:8-13(1992)

Cloning and characterization of a human angiotensin II type 1 receptor

Bergsma D.J., Ellis C., Kumar C., Nuthalaganti P., Kersten H., Elshourbagy N.A., Griffin E., Stadel J.M., Aiyar N.,

Biochem. Biophys. Res. Commun. 183:989-995(1992)

Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor

Takayanagi R., Ohnaka K., Sakai Y., Nakao R., Yanase T., Haji M., Inagami T., Furuta H., Gou D.F., Nakamuta M., Nawata H.,

Biochem. Biophys. Res. Commun. 183:910-916(1992)

Genetic analysis of the human type-1 angiotensin II receptor

Curnow K.M., Pascoe L., White P.C.,

Mol. Endocrinol. 6:1113-1118(1992)