ALB

Synonyms

Serum Albumin, PRO0883, ALB, PRO1341, HSA, Albumin, PRO0903

Description

Binds water, Ca, Na, K, fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc . Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli . Does not prevent iron uptake by the bacterial siderophore aerobactin .

KO Status

F2 (-/-)

Drug Information

Launched drugs: 8
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Albumin Human(Sanquin Plasma Products)

Approved

Sanquin Plasma Products

Albumin Human (Biotest Pharma GmbH)

Approved

Biotest Pharma Gmbh

Hypovolemia

Human Albumin(Guangdong Danxia)

Approved

Guangdong Danxia Biopharmaceutical Co Ltd

Hypovolemia

Human albumin(Tonrol Bio-Pharmaceutical)

Approved

Tonrol Bio-Pharmaceutical Co Ltd

Hypovolemia

Human Serum Albumin (Green Cross)

Approved

Green Cross China Biological Products Co Ltd

Hypovolemia

20% Human albumin (Hemarus Therapeutics)

Approved

Hemarus Therapeutics

Hypovolemia, Respiratory Distress Syndrome, Adult, Hypoalbuminemia, Nephrotic Syndrome

Human Albumin(Hangzhou Tigermed)

Hangzhou Tigermed Consulting Co Ltd

Human albumin (Hebei Da'an Pharmaceutical)

Approved

Hebei Daan Pharmaceutical Co Ltd

Fibrosis, Respiratory Distress Syndrome, Adult, Shock, Hemorrhagic

Human Albumin(Huhan Nanyue)

Approved

Hunan Ziguang Huhan Nanyue Pharmaceutical Co Ltd

Human Albumin (SK Plasma)

Approved

Sk Plasma

References


Title

Authors

Source

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Shaklai N., Garlick R.L., Bunn H.F.,

J. Biol. Chem. 259:3812-3817(1984)

Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites

Iberg N., Fluckiger R.,

J. Biol. Chem. 261:13542-13545(1986)

A nucleotide insertion and frameshift cause analbuminemia in an Italian family

Watkins S., Madison J., Galliano M., Minchiotti L., Putnam F.W.,

Proc. Natl. Acad. Sci. U.S.A. 91:2275-2279(1994)

Albumin as a zinc carrier: properties of its high-affinity zinc-binding site

Lu J., Stewart A.J., Sadler P.J., Pinheiro T.J., Blindauer C.A.,

Biochem. Soc. Trans. 36:1317-1321(2008)

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography

Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.,

Proteomics 8:1346-1361(2008)

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions

Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.,

Sci. Signal. 2:RA46-RA46(2009)

Initial characterization of the human central proteome

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BMC Syst. Biol. 5:17-17(2011)

The full-ORF clone resource of the German cDNA consortium

Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.,

BMC Genomics 8:399-399(2007)

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,

Nature 434:724-731(2005)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)