APLNR

Synonyms

AGTRL1, Angiotensin receptor-like 1, Apelin receptor, APJ, APLNR, G-Protein Coupled Receptor HG11, Angiotensin II Receptor-Like 1, APJ (Apelin) Receptor, G Protein-Coupled Receptor APJ, G-Protein Coupled Receptor APJ, HG11 Orphan Receptor, APJ Receptor, APJR, HG11, Apelin Receptors, FLJ90771

Description

APLNR (Apelin receptor) is a receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure.Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

KO Status

RenMab: F0

RenLite: F2 (-/-)

Drug Information

Drugs in clinical trials: 3
Latest Research Phase: Phase 1 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Apelin-13

Apelin-13, 65-77-Apelin

Phase 1 Clinical

Centre Hospitalier Universitaire (Chu) De Toulouse

Diabetes Mellitus, Type 2

MM-07

MM-07

Phase 1 Clinical

University Of Cambridge

Pulmonary Arterial Hypertension

Azelaprag

AMG-986, BGE-105

Phase 1 Clinical

Amgen Inc

Heart Failure

Apelin

Pending

University Of Cambridge, Astrazeneca Plc

Diabetes Mellitus, Type 2