AQP-4, Mercurial-insensitive water channel, MIWC, WCH4, Aquaporin Type4, Aquaporin 4, Aquaporin-4
Aquaporin 4 (AQP4) is the main water channel protein expressed in the central nervous system (CNS). It plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability.
RenMab: F1 (+/-)
Drug in clinical trials: 1
Latest Research Phase: Phase 1 Clinical
Phase 1 Clinical
Stroke, Brain Edema
Stroke; Stroke, Acute; Stroke, Ischemic