BK2R

Synonyms

B2R, BK-2 receptor, BKR2, BDKRB2, B2 bradykinin receptor, Bradykinin Receptor B2, BK-2, BRB2, BK2, Receptor, Bradykinin B2, BK2R

Description

BKR2 (Bradykinin B2 receptor) is a receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

KO Status

F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 2
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Icatibant Acetate

SHP-667, HOE-140, JE-049, TAK-667

Approved

Shire Development Llc

Joint Diseases, Angioedema, Angioedemas, Hereditary

PHA-121

PHA-121, PHA-022121, PHVS-416

Phase 2 Clinical

Pharvaris

Hereditary Angioedema Types I and II, Angioedemas, Hereditary

Breceptin

B-201, B-9870, CU-201, NSC-710295

Phase 1 Clinical

University Of Colorado

Neoplasms

Fasitibant chloride hydrochloride

MEN-16132

Pending

Menarini

Osteoarthritis, Knee, Osteoarthritis

CP-0364

CP-0364

Discontinued

Cortech

Rheumatic Diseases, Inflammation

Labradimil

RMP-7, ALK01-040

Discontinued

Alkermes Plc

HIV Infections, Meningitis, Cryptococcal, Brain Neoplasms

Deltibant

CP-0127, SB-238592

Discontinued

Cortech

Systemic Inflammatory Response Syndrome

Anatibant Mesilate

XY-2405, LF-16-0687MS

Discontinued

Abbvie Inc

Brain Injuries

NPC-567

NOVA-567, npc-5670

Discontinued

Scios Pharma

Asthma

FR-173657

FK-3657, FR-173657

Discontinued

Astellas Pharma Inc

Colitis, Ulcerative, Asthma

References


Title

Authors

Source

Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor

Hess J.F.R., Borkowski J.A., Young G.S., Strader C.D., Ransom R.W.,

Biochem. Biophys. Res. Commun. 184:260-268(1992)

Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14

Powell S.J., Slynn G., Thomas C., Hopkins B., Briggs I., Graham A.,

Genomics 15:435-438(1993)

Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity

McIntyre P., Phillips E., Skidmore E., Brown M., Webb M.,

Mol. Pharmacol. 44:346-355(1993)

Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene

Eggerickx D., Raspe E., Bertrand D., Vassart G., Parmentier M.,

Biochem. Biophys. Res. Commun. 187:1306-1313(1992)

Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor

Ma J.-X., Wang D.-Z., Ward D.C., Chen L., Dessai T., Chao J., Chao L.,

Genomics 23:362-369(1994)

Identification of polymorphic sites of the human bradykinin B2 receptor gene

Braun A., Kammerer S., Boehme E., Mueller B., Roscher A.A.,

Biochem. Biophys. Res. Commun. 211:234-240(1995)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Structure of the bradykinin B2 receptors' amino terminus

Abdalla S., Godovac-Zimmermann J., Braun A., Roscher A.A., Mueller-Esterl W., Quitterer U.,

Biochemistry 35:7514-7519(1996)

Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1

Yeh J.C., Otte L.A., Frangos J.A.,

Biochemistry 47:9029-9039(2008)

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function

Blaukat A., Pizard A., Breit A., Wernstedt C., Alhenc-Gelas F., Muller-Esterl W., Dikic I.,

J. Biol. Chem. 276:40431-40440(2001)