Complement C6, Complement Component 6, Complement Component C6, C6


C6 is constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

KO Status

RenMab: F2 (-/-)

Drug Information

Drug Name





Clinical Trials





Brain Injuries, Traumatic, Nerve Degeneration, Guillain-Barre Syndrome





Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6

Haefliger J.-A., Tschopp J., Vial N., Jenne D.E.,

J. Biol. Chem. 264:18041-18051(1989)

The molecular architecture of human complement component C6

Discipio R.G., Hugli T.E.,

J. Biol. Chem. 264:16197-16206(1989)

Structure of the human C6 gene

Hobart M.J., Fernie B., Discipio R.G.,

Biochemistry 32:6198-6205(1993)

The DNA sequence and comparative analysis of human chromosome 5

Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Rubin E.M.,

Nature 431:268-274(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Structural homology of complement protein C6 with other channel-forming proteins of complement

Chakravarti D.N., Chakravarti B., Parra C.A., Mueller-Eberhard H.J.,

Proc. Natl. Acad. Sci. U.S.A. 86:2799-2803(1989)

Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement

Lengweiler S., Schaller J., DiScipio R.G., Rickli E.E.,

Biochim. Biophys. Acta 1342:13-18(1997)

The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues

Hofsteenge J., Blommers M., Hess D., Furmanek A., Miroshnichenko O.,

J. Biol. Chem. 274:32786-32794(1999)

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry

Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.,

J. Proteome Res. 4:2070-2080(2005)

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.,

J. Proteomics 96:253-262(2014)