Chemokine (C-C Motif) Ligand 11, Eotaxin-1, SCYA11, Small-Inducible Cytokine A11, Chemokine CCL11, MGC22554, C-C motif chemokine 11, Eosinophil chemotactic protein, Eotaxin, CCL11, C-C Motif Chemokine Ligand 11, Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin)

KO Status

RenMab: F0

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name





Clinical Trials


CAT-213, iCo-008

Phase 2 Clinical

Medimmune Llc

Non-alcoholic Fatty Liver Disease, Conjunctivitis, Allergic, Colitis, Ulcerative, Pemphigoid, Bullous, Asthma, Crohn Disease, Dermatitis, Atopic





Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts

Noso N., Bartels J., Mallet A.I., Mochizuki M., Christophers E., Schroeder J.-M.,

Eur. J. Biochem. 253:114-122(1998)

Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation

Crump M.P., Rajarathnam K., Kim K.S., Clark-Lewis I., Sykes B.D.,

J. Biol. Chem. 273:22471-22479(1998)

Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia

Garcia-Zepeda E.A., Rothenberg M.E., Ownbey T.R., Leder P., Luster A.D.,

Nat. Med. 2:449-456(1996)

Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils

Ponath P.D., Qin S., Ringler D.J., Clark-Lewis I., Wang J., Kassam N., Smith H., Shi X., Gonzalo J.A., Newman W., Gutierrez-Ramos J.-C., Mackay C.R.,

J. Clin. Invest. 97:604-612(1996)

Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3

Kitaura M., Nakajima T., Imai T., Harada S., Combadiere C., Tiffany H.L., Murphy P.M., Yoshie O.,

J. Biol. Chem. 271:7725-7730(1996)

Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants

Bartels J., Schlueter C., Richter E., Noso N., Kulke R., Christophers E., Schroeder J.-M.,

Biochem. Biophys. Res. Commun. 225:1045-1051(1996)

Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine

Garcia-Zepeda E.A., Rothenberg M.E., Weremowicz S., Sarafi M.N., Morton C.C., Luster A.D.,

Genomics 41:471-476(1997)

Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene

Hein H., Schlueter C., Kulke R., Christophers E., Schroeder J.-M., Bartels J.,

Biochem. Biophys. Res. Commun. 237:537-542(1997)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)