CCR2

Synonyms

C-C Chemokine Receptor Type 2, MCP-1 Receptor, CD192 Antigen, CCR2A, CCR2B, CD192, CKR2A, CKR2B, CKR2, Receptors, CCR2, FLJ78302, Monocyte Chemotactic Protein 1 Receptor, MCP-1-R, C-C CKR-2, CMKBR2, Monocyte chemoattractant protein 1 receptor, CCR-2, CCR2, C-C Motif Chemokine Receptor 2, Chemokine (C-C Motif) Receptor 2, CC-CKR-2

KO Status

F2 (-/-)

Drug Information

Drugs in clinical trials: 7
Latest Research Phase: Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Cenicriviroc mesylate

CVC, TAK-652, TBR-652, CCR5/CCR2 antagonist

Phase 3 Clinical

Tobira Therapeutics, Takeda Pharmaceutical Co Ltd

Prediabetic State, HIV Infections, Acquired Immunodeficiency Syndrome, Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Liver Cirrhosis, Cholangitis, Sclerosing, Hepatic Insufficiency, Obesity, Cognition Disorders

Cenicriviroc mesylate/Tropifexor

LJC-242

Phase 2 Clinical

Novartis Pharma Ag

Non-alcoholic Fatty Liver Disease

Plozalizumab

TAK-202, MLN-1202

Phase 2 Clinical

Millennium Pharmaceuticals Inc

Plaque, Atherosclerotic, Atherosclerosis, Arthritis, Rheumatoid, Scleroderma, Systemic, Multiple Sclerosis, Diabetic Nephropathies, Melanoma

CCX-872

CCX-872, CCX-872-B

Phase 2 Clinical

Chemocentryx

Pancreatic Neoplasms

BMS-813160

BMS-813160

Phase 2 Clinical

Bristol-Myers Squibb Company

Pancreatic Neoplasms, Diabetic Nephropathies, Hyperplasia, Colorectal Neoplasms

CCX-140

CCX-140, CCX-140B

Phase 2 Clinical

Chemocentryx

Diabetes Mellitus, Type 2, Glomerulosclerosis, Focal Segmental, Diabetic Nephropathies

BMS-687681

BMS-687681

Phase 1 Clinical

Bristol-Myers Squibb Company

Neoplasms

CCX-587

CCX-587

Preclinical

Chemocentryx

Psoriasis

INCB-003284

INCB-3284, INCB-003284

Pending

Incyte Corp

Arthritis, Rheumatoid, Diabetes Mellitus

JNJ-247909290

JNJ-247909290

Pending

Janssen Global Services Llc, Johnson & Johnson

Autoimmune Diseases, Obesity, Inflammation, Diabetes Mellitus

References


Title

Authors

Source

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails

Charo I.F., Myers S.J., Herman A., Franci C., Connolly A.J., Coughlin S.R.,

Proc. Natl. Acad. Sci. U.S.A. 91:2752-2756(1994)

cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor

Yamagami S., Tokuda Y., Ishii K., Tamaka H., Endo N.,

Biochem. Biophys. Res. Commun. 202:1156-1162(1994)

Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking

Wong L.-M., Myers S.J., Tsou C.-L., Gosling J., Arai H., Charo I.F.,

J. Biol. Chem. 272:1038-1045(1997)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression

Smith M.W., Dean M., Carrington M., Winkler C., Huttley G.A., Lomb D.A., Goedert J.J., O'Brien T.R., Jacobson L.P., Kaslow R., Buchbinder S., Vittinghoff E., Vlahov D., Hoots K., Hilgartner M.W., O'Brien S.J.,

Science 277:959-965(1997)

Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression

Mummidi S., Ahuja S.S., Gonzalez E., Anderson S.A., Santiago E.N., Stephan K.T., Craig F.E., O'Connell P., Tryon V., Clark R.A., Dolan M.J., Ahuja S.K.,

Nat. Med. 4:786-793(1998)

The DNA sequence, annotation and analysis of human chromosome 3

Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Gibbs R.A.,

Nature 440:1194-1198(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

IL-2-Regulated Expression of the Monocyte Chemotactic Protein-1 Receptor (CCR2) in Human NK Cells

Polentarutti N., Allavena P., Bianchi G., Giardina G., Basile A., Sozzani S., Mantovani A., Introna M.,

J. Immunol. 158:2689-2694(1997)

The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor

Mellado M., Rodriguez-Frade J.M., Aragay A., del Real G., Martin A.M., Vila-Coro A.J., Serrano A., Mayor F. Jr., Martinez-A C.,

J. Immunol. 161:805-813(1998)