CCR5

Synonyms

CCR-5, Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene), C-C Motif Chemokine Receptor 5 A159A, Chemokine Recptor CCR5 Delta32, C-C Chemokine Receptor Type 5, Chemokine Receptor CCR5, CD195 Antigen, C-C CKR-5, CCCKR5, IDDM22, CKR-5, CKR5, Receptors, CCR5, C-C Motif Chemokine Receptor 5, CD195, CHEMR13, CCR5, HIV-1 fusion coreceptor, C-C Motif Chemokine Receptor 5 (Gene/Pseudogene), Chemokine (C-C Motif) Receptor 5, CC-CKR-5, CMKBR5

KO Status

F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 12
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Maraviroc

MVC, UK-427857

Approved

Viiv Healthcare

HIV Infections, Acquired Immunodeficiency Syndrome, Arthritis, Rheumatoid

Leronlimab

PA-14, PRO-140, HuPRO-140

NDA/BLA

Cytodyn

HIV Infections, Solid tumours, Non-alcoholic Fatty Liver Disease, Triple Negative Breast Neoplasms, Graft vs Host Disease, Coronavirus Disease 2019 (COVID-19)

Cenicriviroc mesylate

CVC, TAK-652, TBR-652, CCR5/CCR2 antagonist

Phase 3 Clinical

Tobira Therapeutics, Takeda Pharmaceutical Co Ltd

Prediabetic State, HIV Infections, Acquired Immunodeficiency Syndrome, Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Liver Cirrhosis, Cholangitis, Sclerosing, Hepatic Insufficiency, Obesity, Cognition Disorders

Vicriviroc

SCH-D, MK-4176, SCH-417, Sch-417690

Phase 2 Clinical

Merck & Co Inc

HIV Infections, Acquired Immunodeficiency Syndrome, Colorectal Neoplasms

SB-728-T

SB-728-T, SB-728mR-T

Phase 2 Clinical

Sangamo Biosciences

HIV Infections

CAL-1-transduced hematopoietic stem cell gene therapy (Calimmune)

Cal-1

Phase 2 Clinical

Calimmune

HIV Infections, Breast Neoplasms, Neoplasm Metastasis

BMS-813160

BMS-813160

Phase 2 Clinical

Bristol-Myers Squibb Company

Pancreatic Neoplasms, Colorectal Neoplasms, Diabetic Nephropathies, Hyperplasia

Cenicriviroc mesylate/Tropifexor

LJC-242

Phase 2 Clinical

Novartis Pharma Ag

Non-alcoholic Fatty Liver Disease

SB-728-HSC

SB-728-HSC, SB-728-HSPC, SB-728mR-HSPC

Phase 1 Clinical

Sangamo Biosciences

HIV Infections

Emtricitabine/Maraviroc/Tenofovir Disoproxil Fumarate

Phase 1 Clinical

University Of Texas Medical Branch, Oak Crest Institute Of Science, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Auritec Pharmaceuticals

HIV Infections

References


Title

Authors

Source

Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks

Saez-Cirion A., Versmisse P., Truong L.X., Chakrabarti L.A., Carpentier W., Barre-Sinoussi F., Scott-Algara D., Pancino G.,

Retrovirology 3:81-81(2006)

Shared and distinct genetic variants in type 1 diabetes and celiac disease

Smyth D.J., Plagnol V., Walker N.M., Cooper J.D., Downes K., Yang J.H.M., Howson J.M.M., Stevens H., McManus R., Wijmenga C., Heap G.A., Dubois P.C., Clayton D.G., Hunt K.A., van Heel D.A., Todd J.A.,

N. Engl. J. Med. 359:2767-2777(2008)

Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization

Kraft K., Olbrich H., Majoul I., Mack M., Proudfoot A., Oppermann M.,

J. Biol. Chem. 276:34408-34418(2001)

Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines

Bannert N., Craig S., Farzan M., Sogah D., Santo N.V., Choe H., Sodroski J.,

J. Exp. Med. 194:1661-1673(2001)

JM4 is a four-transmembrane protein binding to the CCR5 receptor

Schweneker M., Bachmann A.S., Moelling K.,

FEBS Lett. 579:1751-1758(2005)

G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers

Huettenrauch F., Pollok-Kopp B., Oppermann M.,

J. Biol. Chem. 280:37503-37515(2005)

CCR5 deficiency increases risk of symptomatic West Nile virus infection

Glass W.G., McDermott D.H., Lim J.K., Lekhong S., Yu S.F., Frank W.A., Pape J., Cheshier R.C., Murphy P.M.,

J. Exp. Med. 203:35-40(2006)

Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity

Tadagaki K., Tudor D., Gbahou F., Tschische P., Waldhoer M., Bomsel M., Jockers R., Kamal M.,

Blood 119:4908-4918(2012)

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum

Sauvageau E., Rochdi M.D., Oueslati M., Hamdan F.F., Percherancier Y., Simpson J.C., Pepperkok R., Bouvier M.,

Traffic 15:383-400(2014)

Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity

Paterlini M.G.,

Biophys. J. 83:3012-3031(2002)