CCR5

Synonyms

CCR-5, Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene), C-C Motif Chemokine Receptor 5 A159A, Chemokine Recptor CCR5 Delta32, C-C Chemokine Receptor Type 5, Chemokine Receptor CCR5, CD195 Antigen, C-C CKR-5, CCCKR5, IDDM22, CKR-5, CKR5, Receptors, CCR5, C-C Motif Chemokine Receptor 5, CD195, CHEMR13, CCR5, HIV-1 fusion coreceptor, C-C Motif Chemokine Receptor 5 (Gene/Pseudogene), Chemokine (C-C Motif) Receptor 5, CC-CKR-5, CMKBR5,

KO Status

F0

Drug Information

Launched drugs: 12
Drug in clinical trials: 1
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Maraviroc

MVC, UK-427857

Approved

Viiv Healthcare

HIV Infections, Acquired Immunodeficiency Syndrome, Arthritis, Rheumatoid

AGT 103-T

AGT 103-T

Preclinical

Applied Genetic Technologies Corporation

HIV Infections

Leronlimab

PA-14, PRO-140, HuPRO-140

NDA/BLA

Cytodyn

HIV Infections, Non-alcoholic Fatty Liver Disease, Coronavirus Disease 2019 (COVID-19), Graft vs Host Disease, Triple Negative Breast Neoplasms

PSC-RANTES

Preclinical

Mintaka Medical Research Foundation

HIV Infections

Cenicriviroc mesylate

CVC, TAK-652, TBR-652, CCR5/CCR2 antagonist

Phase 3 Clinical

Tobira Therapeutics, Takeda Pharmaceutical Co Ltd

Prediabetic State, HIV Infections, Acquired Immunodeficiency Syndrome, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2, Liver Cirrhosis, Cholangitis, Sclerosing, Hepatic Insufficiency, Obesity, Cognition Disorders

Cenicriviroc mesylate/Tropifexor

LJC-242

Phase 2 Clinical

Novartis Pharma Ag

Non-alcoholic Fatty Liver Disease

CAL-1-transduced hematopoietic stem cell gene therapy (Calimmune)

Cal-1

Phase 2 Clinical

Calimmune

HIV Infections, Breast Neoplasms, Neoplasm Metastasis

Vicriviroc

SCH-D, MK-4176, SCH-417, Sch-417690

Phase 2 Clinical

Merck & Co Inc

HIV Infections, Acquired Immunodeficiency Syndrome, Colorectal Neoplasms

SB-728-T

SB-728-T, SB-728mR-T

Phase 2 Clinical

Sangamo Biosciences

HIV Infections

BMS-813160

BMS-813160

Phase 2 Clinical

Bristol-Myers Squibb Company

Pancreatic Neoplasms, Colorectal Neoplasms, Diabetic Nephropathies, Hyperplasia

SB-728-HSC

SB-728-HSC, SB-728-HSPC, SB-728mR-HSPC

Phase 1 Clinical

Sangamo Biosciences

HIV Infections

BMS-687681

BMS-687681

Phase 1 Clinical

Bristol-Myers Squibb Company

Neoplasms

Thioraviroc

Phase 1 Clinical

Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences

HIV Infections

Emtricitabine/Maraviroc/Tenofovir Disoproxil Fumarate

Phase 1 Clinical

University Of Texas Medical Branch, Oak Crest Institute Of Science, National Institute Of Child Health And Human Development, Auritec Pharmaceuticals

HIV Infections

GSK-706769

GSK-706769

Phase 1 Clinical

Glaxosmithkline Plc

HIV Infections, Arthritis, Rheumatoid, Autoimmune Diseases

Vicriviroc/MK-2048

VCV/MK-2048, MK-2048A IVR, MK-2048/MK-4176, MK-4176/MK-2048

Pending

Merck Sharp & Dohme Corp, National Institute Of Allergy And Infectious Diseases

HIV Infections

Lamivudine/Maraviroc/Zidovudine

GSK-2838510

Pending

Glaxosmithkline Plc

HIV Infections

CCR5-targeting HIV vaccine (Kuros Biosciences)

CCR5Qb

Pending

Cytos

HIV Infections

VCH-286

VCH-286

Pending

Vertex Pharmaceuticals Incorporated

HIV Infections

INCB-009471

INCB-9471, INCB-009471

Pending

Incyte Corp

HIV Infections