CCR5
Synonyms
CCR-5, Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene), C-C Motif Chemokine Receptor 5 A159A, Chemokine Recptor CCR5 Delta32, C-C Chemokine Receptor Type 5, Chemokine Receptor CCR5, CD195 Antigen, C-C CKR-5, CCCKR5, IDDM22, CKR-5, CKR5, Receptors, CCR5, C-C Motif Chemokine Receptor 5, CD195, CHEMR13, CCR5, HIV-1 fusion coreceptor, C-C Motif Chemokine Receptor 5 (Gene/Pseudogene), Chemokine (C-C Motif) Receptor 5, CC-CKR-5, CMKBR5
KO Status
F0
Drug Information
Launched drug: 1
Drugs in clinical trials: 12
Latest Research Phase: Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Maraviroc
MVC, UK-427857
Approved
Viiv Healthcare
HIV Infections, Acquired Immunodeficiency Syndrome, Arthritis, Rheumatoid
Leronlimab
PA-14, PRO-140, HuPRO-140
NDA/BLA
Cytodyn
HIV Infections, Solid tumours, Non-alcoholic Fatty Liver Disease, Triple Negative Breast Neoplasms, Graft vs Host Disease, Coronavirus Disease 2019 (COVID-19)
Cenicriviroc mesylate
CVC, TAK-652, TBR-652, CCR5/
Phase 3 Clinical
Tobira Therapeutics, Takeda Pharmaceutical Co Ltd
Prediabetic State, HIV Infections, Acquired Immunodeficiency Syndrome, Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Liver Cirrhosis, Cholangitis, Sclerosing, Hepatic Insufficiency, Obesity, Cognition Disorders
Vicriviroc
SCH-D, MK-4176, SCH-417, Sch-417690
Phase 2 Clinical
Merck & Co Inc
HIV Infections, Acquired Immunodeficiency Syndrome, Colorectal Neoplasms
SB-728-T
SB-728-T, SB-728mR-T
Phase 2 Clinical
Sangamo Biosciences
HIV Infections
CAL-1-transduced hematopoietic stem cell gene therapy (Calimmune)
Cal-1
Phase 2 Clinical
Calimmune
HIV Infections, Breast Neoplasms, Neoplasm Metastasis
BMS-813160
BMS-813160
Phase 2 Clinical
Bristol-Myers Squibb Company
Pancreatic Neoplasms, Colorectal Neoplasms, Diabetic Nephropathies, Hyperplasia
Cenicriviroc mesylate/Tropifexor
LJC-242
Phase 2 Clinical
Novartis Pharma Ag
Non-alcoholic Fatty Liver Disease
SB-728-HSC
SB-728-HSC, SB-728-HSPC, SB-728mR-HSPC
Phase 1 Clinical
Sangamo Biosciences
HIV Infections
Emtricitabine/Maraviroc/Tenofovir Disoproxil Fumarate
Phase 1 Clinical
University Of Texas Medical Branch, Oak Crest Institute Of Science, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Auritec Pharmaceuticals
HIV Infections
References
Title
Authors
Source
Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks
Saez-Cirion A., Versmisse P., Truong L.X., Chakrabarti L.A., Carpentier W., Barre-Sinoussi F., Scott-Algara D., Pancino G.,
Retrovirology 3:81-81(2006)
Shared and distinct genetic variants in type 1 diabetes and celiac disease
Smyth D.J., Plagnol V., Walker N.M., Cooper J.D., Downes K., Yang J.H.M., Howson J.M.M., Stevens H., McManus R., Wijmenga C., Heap G.A., Dubois P.C., Clayton D.G., Hunt K.A., van Heel D.A., Todd J.A.,
N. Engl. J. Med. 359:2767-2777(2008)
Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization
Kraft K., Olbrich H., Majoul I., Mack M., Proudfoot A., Oppermann M.,
J. Biol. Chem. 276:34408-34418(2001)
Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines
Bannert N., Craig S., Farzan M., Sogah D., Santo N.V., Choe H., Sodroski J.,
J. Exp. Med. 194:1661-1673(2001)
JM4 is a four-transmembrane protein binding to the CCR5 receptor
Schweneker M., Bachmann A.S., Moelling K.,
FEBS Lett. 579:1751-1758(2005)
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers
Huettenrauch F., Pollok-Kopp B., Oppermann M.,
J. Biol. Chem. 280:37503-37515(2005)
CCR5 deficiency increases risk of symptomatic West Nile virus infection
Glass W.G., McDermott D.H., Lim J.K., Lekhong S., Yu S.F., Frank W.A., Pape J., Cheshier R.C., Murphy P.M.,
J. Exp. Med. 203:35-40(2006)
Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity
Tadagaki K., Tudor D., Gbahou F., Tschische P., Waldhoer M., Bomsel M., Jockers R., Kamal M.,
Blood 119:4908-4918(2012)
CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum
Sauvageau E., Rochdi M.D., Oueslati M., Hamdan F.F., Percherancier Y., Simpson J.C., Pepperkok R., Bouvier M.,
Traffic 15:383-400(2014)
Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity
Paterlini M.G.,
Biophys. J. 83:3012-3031(2002)