CD106

Synonyms

VCAM1, Vascular cell adhesion protein 1, V-CAM 1, CD106, Vascular Cell Adhesion Molecule 1, CD106 Antigen, INCAM-100, VCAM-1, Vascular Cell Adhesion Molecule-1

Description

Vascular cell adhesion molecule 1 (VCAM-1) also known as cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 appears to function in leukocyte-endothelial cell adhesion. It interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

KO Status

F2 (-/-)

Drug Information

Launched drug: 1
Drug in clinical trials: 1
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Tocopherol acetate

DSE-9912

Approved

Venous Thromboembolism, Atherosclerosis, Intermittent Claudication, Thrombosis, Diabetic Retinopathy

99mTccAbVCAM1‐5

99mTccAbVCAM1‐5

Phase 1 Clinical

Medico-Economic Evaluation Unit , University Hospital, Grenoble

Atherosclerosis

FG-4497

FG-4497

Preclinical

Fibrogen

Psoriasis, Arthritis

JCAR-023

JCAR-023

Pending

Seattle Children'S Research Institute

Neuroblastoma

DZ-13

DZ13, DZ-13

Pending

University Of New South Wales, Royal Prince Alfred Hospital

Carcinoma, Basal Cell, Melanoma

CE7R

Discontinued

Fred Hutchinson Cancer Research Center, National Cancer Institute

Neuroblastoma

Elsibucol

AGI-1096

Discontinued

Atherogenics

Rejection of organ transplantation

References


Title

Authors

Source

Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)

Iademarco M.F., McQuillan J.J., Rosen G.D., Dean D.C.,

J. Biol. Chem. 267:16323-16329(1992)

Alternative splicing of human VCAM-1 in activated vascular endothelium

Cybulsky M.I., Fries J.W., Williams A.J., Sultan P., Davis V.M., Gimbrone M.A. Jr., Collins T.,

Am. J. Pathol. 138:815-820(1991)

Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1

Osborn L., Vassallo C., Benjamin C.D.,

J. Exp. Med. 176:99-107(1992)

Signal peptide prediction based on analysis of experimentally verified cleavage sites

Zhang Z., Henzel W.J.,

Protein Sci. 13:2819-2824(2004)

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry

Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.,

J. Proteome Res. 4:2070-2080(2005)

Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution

Jones E.Y., Harlos K., Bottomley M.J., Robinson R.C., Driscoll P.C., Edwards R.M., Clements J.M., Dudgeon T.J., Stuart D.I.,

Nature 373:539-544(1995)

The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction

Wang J.-H., Pepinsky R.B., Stehle T., Liu J.-H., Karpusas M., Browning B., Osborn L.,

Proc. Natl. Acad. Sci. U.S.A. 92:5714-5718(1995)

Structure of a functional fragment of VCAM-1 refined at 1.9-A resolution

Wang J.-H., Stehle T., Pepinsky R.B., Liu J.-H., Karpusas M., Osborn L.,

Acta Crystallogr. D 52:369-379(1996)

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

Osborn L., Hession C., Tizard R., Vassallo C., Luhowskyj S., Chi-Rosso G., Lobb R.,

Cell 59:1203-1211(1989)

Full length vascular cell adhesion molecule 1 (VCAM-1)

Polte T., Newman W., Gopal T.V.,

Nucleic Acids Res. 18:5901-5901(1990)