CD106

Synonyms

VCAM1, Vascular cell adhesion protein 1, V-CAM 1, CD106, Vascular Cell Adhesion Molecule 1, CD106 Antigen, INCAM-100, VCAM-1, Vascular Cell Adhesion Molecule-1,

Description

Vascular cell adhesion molecule 1 (VCAM-1) also known as cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 appears to function in leukocyte-endothelial cell adhesion. It interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

KO Status

F1 (+/-)

Drug Information

Launched drug: 1
Drug in clinical trials: 1
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

FG-4497

FG-4497

Preclinical

Fibrogen

Psoriasis, Arthritis

Tocopherol acetate

DSE-9912

Approved

Venous Thromboembolism, Atherosclerosis, Intermittent Claudication, Thrombosis, Diabetic Retinopathy

99mTccAbVCAM1‐5

99mTccAbVCAM1‐5

Phase 1 Clinical

Medico-Economic Evaluation Unit , University Hospital, Grenoble

Atherosclerosis

JCAR-023

JCAR-023

Pending

Seattle Children'S Research Institute

Neuroblastoma

DZ-13

DZ13, DZ-13

Pending

University Of New South Wales, Royal Prince Alfred Hospital

Carcinoma, Basal Cell, Melanoma

CE7R

Discontinued

Fred Hutchinson Cancer Research Center, National Cancer Institute

Neuroblastoma

Elsibucol

AGI-1096

Discontinued

Atherogenics

Rejection of organ transplantation