CD106
Synonyms
VCAM1, Vascular cell adhesion protein 1, V-CAM 1, CD106, Vascular Cell Adhesion Molecule 1, CD106 Antigen, INCAM-100, VCAM-1, Vascular Cell Adhesion Molecule-1,Description
Vascular cell adhesion molecule 1 (VCAM-1) also known as cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 appears to function in leukocyte-endothelial cell adhesion. It interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
KO Status
F1 (+/-)
Drug Information
Launched drug: 1
Drug in clinical trials: 1
Latest Research Phase:Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
FG-4497
FG-4497
Preclinical
Fibrogen
Psoriasis, Arthritis
Tocopherol acetate
DSE-9912
Approved
Venous Thromboembolism, Atherosclerosis, Intermittent Claudication, Thrombosis, Diabetic Retinopathy
99mTccAbVCAM1‐5
99mTccAbVCAM1‐5
Phase 1 Clinical
Medico-Economic Evaluation Unit , University Hospital, Grenoble
Atherosclerosis
JCAR-023
JCAR-023
Pending
Seattle Children'S Research Institute
Neuroblastoma
DZ-13
DZ13, DZ-13
Pending
University Of New South Wales, Royal Prince Alfred Hospital
Carcinoma, Basal Cell, Melanoma
CE7R
Discontinued
Fred Hutchinson Cancer Research Center, National Cancer Institute
Neuroblastoma
Elsibucol
AGI-1096
Discontinued
Atherogenics
Rejection of organ transplantation