CD133

Synonyms

Antigen AC133, Prominin-1, PROM1, Prominin 1, Prominin-Like Protein 1, PROML1, Stargardt Disease 4 (Autosomal Dominant), Hematopoietic Stem Cell Antigen, Macular Dystrophy, Retinal 2, Prominin (Mouse)-Like 1, CD133 Antigen, HProminin, MSTP061, CORD12, AC133, CD133, MCDR2, STGD4, RP41, AC133 Antigen

Description

May play a role in cell differentiation, proliferation and apoptosis . Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner .

KO Status

RenMab: F0

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

OXS-1650

OXS-1650

Preclinical

University Of Minnesota

Carcinoma, Ovarian Epithelial

Autologous CD133+ hematopoietic stem cells (University of Wisconsin-Madison)

Discontinued

University Of Wisconsin-Madison

Peripheral Arterial Disease

References


Title

Authors

Source

A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning

Miraglia S., Godfrey W., Yin A.H., Atkins K., Warnke R., Holden J.T., Bray R.A., Waller E.K., Buck D.W.,

Blood 90:5013-5021(1997)

AC133-2, a novel isoform of human AC133 stem cell antigen

Yu Y., Flint A., Dvorin E.L., Bischoff J.,

J. Biol. Chem. 277:20711-20716(2002)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,

Nature 434:724-731(2005)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

AC133, a novel marker for human hematopoietic stem and progenitor cells

Yin A.H., Miraglia S., Zanjani E.D., Almeida-Porada G., Ogawa M., Leary A.G., Olweus J., Kearney J., Buck D.W.,

Blood 90:5002-5012(1997)

Differential expression of prominin-1 (CD133) and prominin-2 in major cephalic exocrine glands of adult mice

Jaszai J., Janich P., Farkas L.M., Fargeas C.A., Huttner W.B., Corbeil D.,

Histochem. Cell Biol. 128:409-419(2007)

Nomenclature of prominin-1 (CD133) splice variants - an update

Fargeas C.A., Huttner W.B., Corbeil D.,

Tissue Antigens 69:602-606(2007)

The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease

Huttner H.B., Janich P., Koehrmann M., Jaszai J., Siebzehnrubl F., Bluemcke I., Suttorp M., Gahr M., Kuhnt D., Nimsky C., Krex D., Schackert G., Loewenbrueck K., Reichmann H., Juettler E., Hacke W., Schellinger P.D., Schwab S., Corbeil D.,

Stem Cells 26:698-705(2008)

Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol

Marzesco A.M., Wilsch-Brauninger M., Dubreuil V., Janich P., Langenfeld K., Thiele C., Huttner W.B., Corbeil D.,

FEBS Lett. 583:897-902(2009)