CD14

Synonyms

CD14, CD14 Molecule, Myeloid Cell-Specific Leucine-Rich Glycoprotein, CD14 Antigen, Monocyte Differentiation Antigen CD14

Description

Coreceptor for bacterial lipopolysaccharide . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway . Binds electronegative LDL (LDL) and mediates the cytokine release induced by LDL .

KO Status

F2 (-/-)

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

IC-14

Phase 2 Clinical

Icos Corporation

Shock, Septic, Motor Neuron Disease, Pneumonia, Sepsis, Respiratory Distress Syndrome, Adult, Amyotrophic Lateral Sclerosis, Dengue, Acute Lung Injury

References


Title

Authors

Source

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage

Haziot A., Chen S., Ferrero E., Low M.G., Silber R., Goyert S.M.,

J. Immunol. 141:547-552(1988)

Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14

Ferrero E., Goyert S.M.,

Nucleic Acids Res. 16:4173-4173(1988)

CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes

Estruch M., Bancells C., Beloki L., Sanchez-Quesada J.L., Ordonez-Llanos J., Benitez S.,

Atherosclerosis 229:356-362(2013)

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.,

J. Proteomics 96:253-262(2014)

27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide

Kim S.M., Kim B.Y., Eo S.K., Kim C.D., Kim K.,

Biochim. Biophys. Acta 1852:442-450(2015)

SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation

Yang L., Carrillo M., Wu Y.M., DiAngelo S.L., Silveyra P., Umstead T.M., Halstead E.S., Davies M.L., Hu S., Floros J., McCormack F.X., Christensen N.D., Chroneos Z.C.,

PLoS ONE 10:E0126576-E0126576(2015)

The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket

Kelley S.L., Lukk T., Nair S.K., Tapping R.I.,

J. Immunol. 190:1304-1311(2013)

Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones

Setoguchi M., Nasu N., Yoshida S., Higuchi Y., Akizuki S., Yamamoto S.,

Biochim. Biophys. Acta 1008:213-222(1989)

Monocyte antigen CD14 is a phospholipid anchored membrane protein

Simmons D.L., Tan S., Tenen D.G., Nicholson-Weller A., Seed B.,

Blood 73:284-289(1989)

Natural selection in the TLR-related genes in the course of primate evolution

Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.,

Immunogenetics 60:727-735(2008)