CD14, CD14 Molecule, Myeloid Cell-Specific Leucine-Rich Glycoprotein, CD14 Antigen, Monocyte Differentiation Antigen CD14

KO Status

RenMab: F1 (+/-)

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name





Clinical Trials



Phase 2 Clinical

Icos Corporation

Shock, Septic, Motor Neuron Disease, Pneumonia, Sepsis, Respiratory Distress Syndrome, Adult, Acute Lung Injury, Amyotrophic Lateral Sclerosis, Dengue





The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage

Haziot A., Chen S., Ferrero E., Low M.G., Silber R., Goyert S.M.,

J. Immunol. 141:547-552(1988)

Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14

Ferrero E., Goyert S.M.,

Nucleic Acids Res. 16:4173-4173(1988)

CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes

Estruch M., Bancells C., Beloki L., Sanchez-Quesada J.L., Ordonez-Llanos J., Benitez S.,

Atherosclerosis 229:356-362(2013)

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.,

J. Proteomics 96:253-262(2014)

27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide

Kim S.M., Kim B.Y., Eo S.K., Kim C.D., Kim K.,

Biochim. Biophys. Acta 1852:442-450(2015)

SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation

Yang L., Carrillo M., Wu Y.M., DiAngelo S.L., Silveyra P., Umstead T.M., Halstead E.S., Davies M.L., Hu S., Floros J., McCormack F.X., Christensen N.D., Chroneos Z.C.,

PLoS ONE 10:E0126576-E0126576(2015)

The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket

Kelley S.L., Lukk T., Nair S.K., Tapping R.I.,

J. Immunol. 190:1304-1311(2013)

Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones

Setoguchi M., Nasu N., Yoshida S., Higuchi Y., Akizuki S., Yamamoto S.,

Biochim. Biophys. Acta 1008:213-222(1989)

Monocyte antigen CD14 is a phospholipid anchored membrane protein

Simmons D.L., Tan S., Tenen D.G., Nicholson-Weller A., Seed B.,

Blood 73:284-289(1989)

Natural selection in the TLR-related genes in the course of primate evolution

Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.,

Immunogenetics 60:727-735(2008)