CD18 Antigens, Complement Component 3 Receptor 3 And 4 Subunit, Leukocyte Cell Adhesion Molecule CD18, LCAMB, Cell Surface Adhesion Glycoprotein (LFA-1/CR3/P150, 959 Beta Subunit Precursor), Integrin, Beta 2 (Complement Component 3 Receptor 3 And 4 Subunit), Complement Receptor C3 Beta-Subunit, MF17, CD18 Antigen, ITGB2, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, CD18, Complement receptor C3 subunit beta, MFI7, LFA-1, Leukocyte-Associated Antigens CD18/11A, CD18/11B, CD18/11C, MAC-1, Integrin Subunit Beta 2, Integrin Beta Chain, Beta 2, LAD, Integrin, Beta 2 (Antigen CD18 (P95), Lymphocyte Function-Associated Antigen 1; Macrophage Antigen 1 (Mac-1) Beta Subunit)


Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.

KO Status

RenMab: Antibody Discovery

Drug Information





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