CD18

Synonyms

CD18 Antigens, ITGB2, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, CD18, Complement receptor C3 subunit beta, MFI7, LFA-1, Leukocyte-Associated Antigens CD18/11A, CD18/11B, CD18/11C, MAC-1, Integrin Subunit Beta 2, Integrin Beta Chain, Beta 2, LAD, Integrin, Beta 2 (Antigen CD18 (P95), Lymphocyte Function-Associated Antigen 1; Macrophage Antigen 1 (Mac-1) Beta Subunit), Complement Component 3 Receptor 3 And 4 Subunit, Leukocyte Cell Adhesion Molecule CD18, LCAMB, Cell Surface Adhesion Glycoprotein (LFA-1/CR3/P150, 959 Beta Subunit Precursor), Integrin, Beta 2 (Complement Component 3 Receptor 3 And 4 Subunit), Complement Receptor C3 Beta-Subunit, MF17, CD18 Antigen

Description

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.

KO Status

RenMab: F2 (-/-)

Drug Information

References


Title

Authors

Source

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Kishimoto T.K., O'Connor K., Lee A., Roberts T.M., Springer T.A.,

Cell 48:681-690(1987)

The gene organisation of the human beta 2 integrin subunit (CD18)

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FEBS Lett. 294:97-103(1991)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence of human chromosome 21

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Nature 405:311-319(2000)

RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1

Denti S., Sirri A., Cheli A., Rogge L., Innamorati G., Putignano S., Fabbri M., Pardi R., Bianchi E.,

J. Biol. Chem. 279:13027-13034(2004)

LFA-1 contributes an early signal for NK cell cytotoxicity

Barber D.F., Faure M., Long E.O.,

J. Immunol. 173:3653-3659(2004)

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms

Fagerholm S.C., Hilden T.J., Nurmi S.M., Gahmberg C.G.,

J. Cell Biol. 171:705-715(2005)

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry

Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.,

J. Proteome Res. 4:2070-2080(2005)

Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins

Xu J., Gao X.-P., Ramchandran R., Zhao Y.-Y., Vogel S.M., Malik A.B.,

Nat. Immunol. 9:880-886(2008)

Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk

Ithychanda S.S., Hsu D., Li H., Yan L., Liu D.D., Liu D., Das M., Plow E.F., Qin J.,

J. Biol. Chem. 284:35113-35121(2009)