CD205
Synonyms
LY75, CD205, Lymphocyte Antigen 75, C-Type Lectin Domain Family 13 Member B, CLEC13B, DEC-205, CD205 Antigen, Gp200-MR6, Ly-75
Description
Lymphocyte antigen 75 also called CD205 is a protein that in humans is encoded by the LY75 gene. Lymphocyte antigen 75 acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment.
KO Status
RenMab: F1 (+/-)
RenLite: F0
Drug Information
Drugs in clinical trials: 2
Latest Research Phase: Phase 2 Clinical
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Rasdegafusp alfa
CDX-1401
Phase 2 Clinical
Ludwig Institute For Cancer Research
Ovarian Neoplasms, Carcinoma, Transitional Cell, Mesothelioma, Breast Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms, Melanoma, Carcinoma, Non-Small-Cell Lung
MEN-1309
MEN-1309, OBT-076
Phase 1 Clinical
Oxford Biotherapeutics, Menarini
Solid tumours, Breast Neoplasms, Lymphoma, Non-Hodgkin
CDX-1402
CDX-1402
Preclinical
Celldex Therapeutics Inc
Neoplasms
References
Title
Authors
Source
The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family
McKay P.F., Imami N., Johns M., Taylor-Fishwick D.A., Sedibane L.M., Totty N.F., Hsuan J.J., Palmer D.B., George A.J.T., Foxwell B.M.J., Ritter M.A.,
Eur. J. Immunol. 28:4071-4083(1998)
cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells
Kato M., Neil T.K., Clark G.J., Morris C.M., Sorg R.V., Hart D.N.J.,
Immunogenetics 47:442-450(1998)
Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1
Kato M., Khan S., Gonzalez N., O'Neill B.P., McDonald K.J., Cooper B.J., Angel N.Z., Hart D.N.J.,
J. Biol. Chem. 278:34035-34041(2003)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,
Nature 434:724-731(2005)
A quantitative atlas of mitotic phosphorylation
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.,
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008)