CD26

Synonyms

DPPIV, Dipeptidyl peptidase IV membrane form, T-cell activation antigen CD26, Adenosine deaminase complexing protein 2, Dipeptidyl peptidase IV soluble form, ADCP2, Dipeptidyl peptidase 4, ADCP-2, DPP4, Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2), DPP IV, TP103, CD26, Dipeptidyl-Peptidase 4, CD26 Antigen, ADABP, Dipeptidylpeptidase 4, Dipeptidyl peptidase IV, Gly-Pro Naphthylamidase, Xaa-Pro-Dipeptidylaminopeptidase, Post-Proline Dipeptidyl Aminopeptidase IV,

Description

Dipeptidyl peptidase IV (DPP4), also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26) is a protein that, in humans, is encoded by the DPP4 gene.Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

KO Status

F2 (-/-)

Drug Information

Launched drugs: 22
Drugs in clinical trials: 28
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Alogliptin Benzoate/Metformin Hydrochloride

Approved

Takeda Pharmaceutical Co Ltd

Diabetes Mellitus, Type 2

Evogliptin Tartrate/Metformin Hydrochloride

DA-1229_01

Approved

Dong-A Pharmaceutical Co Ltd

Diabetes Mellitus, Type 2

Vildagliptin

LAF-237, DSP-7238, LAF-237A, NVP-LAF-237

Approved

Novartis Pharma Ag

Prediabetic State, Diabetes Mellitus, Type 2, Renal Insufficiency, Kidney Diseases, Diabetes Mellitus

Gosogliptin

PF-734200, PF-00734200

NDA/BLA

Pfizer Pharmaceuticals Ltd (China)

Diabetes Mellitus, Type 2, Renal Insufficiency, Chronic

Cetagliptin/Metformin

Preclinical

Shengshi Taike Biological Medicine Technology (Suzhou) Co Ltd

Diabetes Mellitus, Type 2

Anagliptin

SK-0403, CWP-0403

Approved

Sanwa Kagaku Kenkyusho Co Ltd

Diabetes Mellitus, Type 2

Empagliflozin/Linagliptin/Metformin

Approved

Boehringer Ingelheim Gmbh, Eli Lilly And Company

Diabetes Mellitus, Type 2

Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride

Approved

Astrazeneca Plc

Diabetes Mellitus, Type 2

Linagliptin/Metformin Hydrochloride

Approved

Boehringer Ingelheim Gmbh

Diabetes Mellitus, Type 2

Gemigliptin L-tartrate Sesquihydrate/Metformin Hydrochloride

Approved

Lg Life Sciences Ltd

Diabetes Mellitus, Type 2

Teneligliptin Hydrobromide Hydrate/Metformin Hydrochloride

Approved

Handok Inc

Diabetes Mellitus, Type 2

Sitagliptin Phosphate Monohydrate

MK-431, MK-0431, ONO-5435, ONO-5435A, L-000224715

Approved

Merck Sharp & Dohme Corp

Diabetes Mellitus, Type 2, Renal Insufficiency, Glucose Intolerance, Dyslipidemias, Hepatic Insufficiency, Diabetes Mellitus, Kidney Failure, Chronic

Saxagliptin Hydrate

OPC-262, BMS-477118, BMS-477118-11

Approved

Bristol-Myers Squibb Company

Diabetes Mellitus, Type 2, Diabetes Mellitus

Sitagliptin/Ertugliflozin

Approved

Pfizer Pharmaceuticals Ltd (China)

Diabetes Mellitus, Type 2

Gemigliptin L-tartrate Sesquihydrate

LC-150444, LC-15-0444

Approved

Lg Life Sciences

Diabetes Mellitus, Type 2, Hepatic Insufficiency

Trelagliptin Succinate

SYR-111472 succinate, SYR-111472, TAK-472, SYR-472

Approved

Takeda Pharmaceutical Co Ltd

Diabetes Mellitus, Type 2, Diabetes Mellitus

Sitagliptin Phosphate/Metformin Hydrochloride

Approved

Merck & Co Inc

Diabetes Mellitus, Type 2

Linagliptin/Empagliflozin

BI 10773/BI 1356, BI 1356/BI 10773, BI 10773/linagliptin, Linagliptin/BI 10773, BI 1356/empagliflozin, Empagliflozin/BI 1356

Approved

C.H. Boehringer Sohn Ag & Co. Kg

Diabetes Mellitus, Type 2, Cardiovascular Diseases

Dapagliflozin/Saxagliptin/Metformin hydrochloride

Approved

Astrazeneca

Diabetes Mellitus, Type 2

Evogliptin

DA-1229

Approved

Dong-A Pharmaceutical Co Ltd

Diabetes Mellitus, Type 2, Kidney Diseases, Aortic valve diseases, Liver Diseases