CD34

Synonyms

CD34, CD34 Molecule, CD34 Antigen, Hematopoietic Progenitor Cell Antigen CD34, Antigens, CD34

Description

CD34 is an adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

KO Status

F1 (+/-)

Drug Information

Launched drug: 1
Drugs in clinical trials: 14
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Anti-CD34 mab-sirolimus (OrbusNeich)

Approved

Orbusneich

Coronary Restenosis

Autologous stem cell therapy (Shire)

Phase 3 Clinical

Shire Development Llc

Myocardial Ischemia, Peripheral Vascular Diseases, Angina Pectoris, Coronary Disease

Dilanubicel (Nohla Therapeutics)

NLA-101

Phase 3 Clinical

Fred Hutchinson Cancer Research Center

Leukemia, Leukemia, Myeloid, Leukemia, Erythroblastic, Acute, Hematologic Diseases, Communicable Diseases, Neutropenia, Leukemia, Myelomonocytic, Acute, Graft vs Host Disease, Leukemia, Megakaryoblastic, Acute, Acute Radiation Syndrome, Leukemia, Myeloid, Acute, Leukemia, Monocytic, Acute

MB-107

MB-107, IND-14570

Phase 2 Clinical

National Institute Of Allergy And Infectious Diseases, National Institute of Health, Islamabad, St. Jude Children'S Research Hospital, National Heart, Lung And Blood Institute

Immunologic Deficiency Syndromes

Retroviral ADA-transduced CD34+ cells (NHGRI/UCLA)

Phase 2 Clinical

Ucla Biomedical Library

Adenosine deaminase deficiency

Stem cell therapeutics (ExCellThera)

ECT-002, ECT-003, ECT-005, UM171 + UM092, UM171 + UM390

Phase 2 Clinical

Excellthera

Hematologic Neoplasms, Multiple Myeloma, Leukemia, Myeloid, Acute

GSK-2696277

GSK-2696277

Phase 2 Clinical

Glaxosmithkline Plc, Ospedale San Raffaele, Fondazione Telethon

Thalassemia

CLBS-12

CLBS-12

Phase 2 Clinical

Caladrius Biosciences

Atherosclerosis, Thromboangiitis Obliterans, Ischemia

Autologous peripheral blood stem cell therapy (CellProthera)

Phase 2 Clinical

Cellprothera

Myocardial Infarction

Autologous CD34+-enriched hematopoietic stem and progenitor cells (Genenta Science)

Phase 2 Clinical

Genenta Science

Glioblastoma, Multiple Myeloma

References


Title

Authors

Source

Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells

Simmons D.L., Satterthwaite A.B., Tenen D.G., Seed B.,

J. Immunol. 148:267-271(1992)

Structure of the gene encoding CD34, a human hematopoietic stem cell antigen

Satterthwaite A.B., Burn T.C., le Beau M.M., Tenen D.G.,

Genomics 12:788-794(1992)

Two alternative forms of cDNA encoding CD34

Nakamura Y., Komano H., Nakauchi H.,

Exp. Hematol. 21:236-242(1993)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and biological annotation of human chromosome 1

Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Bentley D.R.,

Nature 441:315-321(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34

Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., Greaves M.F., Smart J.E.,

Leukemia 2:793-803(1988)

Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells

Fackler M.J., Civin C.I., Sutherland D.R., Baker M.A., May W.S.,

J. Biol. Chem. 265:11056-11061(1990)

Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells.

Simmons D.L., Satterthwaite A.B., Tenen D.G., Seed B.,

J. Immunol. 148:267-271(1992)

Structure of the gene encoding CD34, a human hematopoietic stem cell antigen.

Satterthwaite A.B., Burn T.C., le Beau M.M., Tenen D.G.,

Genomics 12:788-794(1992)